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However, contradictory results were reported in different Asian populations. The purpose of this study was to determine whether eleven candidate single nucleotide polymorphisms (SNPs) in ERAP1\/ERAP2 and six in RUNX3 genes confer susceptibility to AS with or without acute anterior uveitis (AAU) [AS+AAU+ or AS+AAU\u2013] in Chinese Han. Therefore, a case\u2013control association study was performed in 882 AS+AAU\u2212, 884 AS+AAU+ and 1727 healthy controls. Genotyping was performed using the iPLEXGold genotyping assay. A meta-analysis was performed to assess the association of polymorphisms of ERAP1 with AS susceptibility in Asian populations. No association was found between SNPs of ERAP1\/ERAP2\/RUNX3 and susceptibility of AS with or without AAU. A case\u2013control study between patients with human leucocyte antigen HLA-B27-positive and healthy controls also failed to demonstrate an association of the tested SNP with AS with or without AAU. Moreover, a meta-analysis showed that there was no association of rs30187, rs27037, rs27980, rs27434 and rs27582 in ERAP1 with AS in Chinese Han. Taken together, 17 SNPs in ERAP1\/ERAP2 and RUNX3 genes did not confer disease susceptibility to AS in Chinese Han.<\/jats:p>","DOI":"10.1111\/cei.13121","type":"journal-article","created":{"date-parts":[[2018,2,26]],"date-time":"2018-02-26T14:56:33Z","timestamp":1519656993000},"page":"95-102","source":"Crossref","is-referenced-by-count":19,"title":["ERAP1\/ERAP2 and RUNX3 polymorphisms are not associated with ankylosing spondylitis susceptibility in Chinese Han"],"prefix":"10.1093","volume":"193","author":[{"given":"W","family":"Su","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Du","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Liu","sequence":"additional","affiliation":[{"name":"Rheumatology Department of the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Deng","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q","family":"Cao","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Yuan","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical 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