{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:26:55Z","timestamp":1767850015268,"version":"3.49.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Gruppo Italiano Lotta alla Sclerodermia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,15]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Systemic sclerosis (SSc) is a complex disease characterized by immune dysregulation, extensive vascular damage and widespread fibrosis. Human leucocyte antigen-G (HLA-G) is a non-classic class I major histocompatibility complex (MHC) molecule characterized by complex immunomodulating properties. HLA-G is expressed on the membrane of different cell lineages in both physiological and pathological conditions. HLA-G is also detectable in soluble form (sHLA-G) deriving from the shedding of surface isoforms (sHLA-G1) or the secretion of soluble isoforms (HLA-G5). Several immunosuppressive functions have been attributed to both membrane-bound and soluble HLA-G molecules. The plasma levels of sHLA-G were higher in SSc patients (444\u00b727\u00a0\u00b1\u00a0304\u00b784 U\/ml) compared to controls (16\u00b774\u00a0\u00b1\u00a020\u00b758\u00a0U\/ml) (P\u00a0&amp;lt;\u00a00\u00b70001). The plasma levels of transforming growth factor (TGF)-\u03b2 were higher in SSc patients (18\u00a0937\u00a0\u00b1\u00a015\u00a0217 pg\/ml) compared to controls (11\u00a0099\u00a0\u00b1\u00a06081 pg\/ml; P\u00a0=\u00a00\u00b7003), and a significant correlation was found between TGF-\u03b2 and the plasma levels of total sHLA-G (r\u00a0=\u00a00\u00b765; P\u00a0&amp;lt;\u00a00\u00b701), sHLA-G1 (r\u00a0=\u00a00\u00b760; P\u00a0=\u00a00\u00b7003) and HLA-G5 (r\u00a0=\u00a00\u00b747; P\u00a0=\u00a00\u00b702). The percentage of HLA-G-positive monocytes (0\u00b798\u00a0\u00b1\u00a01\u00b772), CD4+ (0\u00b737\u00a0\u00b1\u00a00\u00b768), CD8+ (2\u00b705\u00a0\u00b1\u00a03\u00b774) and CD4+CD8+ double-positive cells (14\u00b753\u00a0\u00b1\u00a016\u00b788) was higher in SSc patients than in controls (0\u00b711\u00a0\u00b1\u00a00\u00b708, 0\u00b701\u00a0\u00b1\u00a00\u00b701, 0\u00b701\u00a0\u00b1\u00a00\u00b701 and 0\u00b739\u00a0\u00b1\u00a00\u00b740, respectively) (P\u00a0&amp;lt;\u00a00\u00b70001). These data indicate that in SSc the secretion and\/or shedding of soluble HLA-G molecules and the membrane expression of HLA-G by peripheral blood mononuclear cells (PBMC) is clearly elevated, suggesting an involvement of HLA-G molecules in the immune dysregulation of SSc.<\/jats:p>","DOI":"10.1111\/cei.13134","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T16:15:29Z","timestamp":1523895329000},"page":"152-159","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of membrane-bound and soluble forms of human leucocyte antigen-G in systemic sclerosis"],"prefix":"10.1093","volume":"193","author":[{"given":"P","family":"Contini","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Clinical Immunology Unit, University of Genoa and Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Negrini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinical Immunology Unit, University of Genoa and Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Murdaca","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinical Immunology Unit, University of Genoa and Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Borro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinical Immunology Unit, University of Genoa and Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5393-0071","authenticated-orcid":false,"given":"F","family":"Puppo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Clinical Immunology Unit, University of Genoa and Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,5,23]]},"reference":[{"key":"2021120808383515600_cei13134-bib-0001","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1056\/NEJMra0806188","article-title":"Scleroderma","volume":"360","author":"Gabrielli","year":"2009","journal-title":"N Engl J Med"},{"key":"2021120808383515600_cei13134-bib-0002","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy","year":"1988","journal-title":"J Rheumatol"},{"key":"2021120808383515600_cei13134-bib-0003","doi-asserted-by":"crossref","first-page":"e267","DOI":"10.1016\/j.lpm.2014.08.001","article-title":"Pathophysiology of systemic sclerosis: state of the art in 2014","volume":"43","author":"Dumoitier","year":"2014","journal-title":"Presse Med"},{"key":"2021120808383515600_cei13134-bib-0004","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fimmu.2017.00018","article-title":"Phenotypic alterations involved in CD8+ Treg impairment in systemic sclerosis","volume":"8","author":"Negrini","year":"2017","journal-title":"Front Immunol"},{"key":"2021120808383515600_cei13134-bib-0005","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3389\/fimmu.2015.00272","article-title":"Pathogenesis of systemic sclerosis","volume":"6","author":"Pattanaik","year":"2015","journal-title":"Front Immunol"},{"key":"2021120808383515600_cei13134-bib-0006","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1684\/ecn.2015.0360","article-title":"Role of endothelin-1 in the skin fibrosis of systemic sclerosis","volume":"26","author":"Jing","year":"2015","journal-title":"Eur Cytokine Netw"},{"key":"2021120808383515600_cei13134-bib-0007","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/01.RES.0000134644.89917.96","article-title":"Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis","volume":"95","author":"Distler","year":"2004","journal-title":"Circ Res"},{"key":"2021120808383515600_cei13134-bib-0008","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.molimm.2004.06.025","article-title":"Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis","volume":"41","author":"Sato","year":"2004","journal-title":"Mol Immunol"},{"key":"2021120808383515600_cei13134-bib-0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/039463200702000101","article-title":"BAFF and rheumatic autoimmune disorders: implications for disease management and therapy","volume":"20","author":"Bosello","year":"2007","journal-title":"Int J Immunopathol Pharmacol"},{"key":"2021120808383515600_cei13134-bib-0010","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s11926-011-0215-5","article-title":"Dendritic cells: novel players in fibrosis and scleroderma","volume":"14","author":"Lu","year":"2012","journal-title":"Curr Rheumatol Rep"},{"key":"2021120808383515600_cei13134-bib-0011","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.clim.2011.01.013","article-title":"Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis","volume":"139","author":"Fenoglio","year":"2011","journal-title":"Clin Immunol"},{"key":"2021120808383515600_cei13134-bib-0012","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3109\/03009742.2010.528021","article-title":"Altered T-cell and regulatory cell repertoire in patients with diffuse cutaneous systemic sclerosis","volume":"40","author":"Papp","year":"2011","journal-title":"Scand J Rheumatol"},{"key":"2021120808383515600_cei13134-bib-0013","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.autrev.2012.05.004","article-title":"Th17 and regulatory T lymphocytes in primary biliary cirrhosis and systemic sclerosis as models of autoimmune fibrotic diseases","volume":"12","author":"Fenoglio","year":"2012","journal-title":"Autoimmun Rev"},{"key":"2021120808383515600_cei13134-bib-0014","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1002\/art.22927","article-title":"Presence of CD4+CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosis","volume":"56","author":"Parel","year":"2007","journal-title":"Arthritis Rheum"},{"key":"2021120808383515600_cei13134-bib-0015","article-title":"Transforming growth factor-b signaling in systemic sclerosis","author":"Ayers","year":"2017","journal-title":"J Biomed Res"},{"key":"2021120808383515600_cei13134-bib-0016","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s11926-012-0304-0","article-title":"Involvement of PDGF in fibrosis and scleroderma: recent insights from animal models and potential therapeutic opportunities","volume":"15","author":"Iwayama","year":"2013","journal-title":"Curr Rheumatol Rep"},{"key":"2021120808383515600_cei13134-bib-0017","doi-asserted-by":"crossref","first-page":"731","DOI":"10.4049\/jimmunol.144.2.731","article-title":"Human trophoblast and the choriocarcinoma cell line BeWo express a truncated HLA class I molecule","volume":"144","author":"Ellis","year":"1990","journal-title":"J Immunol"},{"key":"2021120808383515600_cei13134-bib-0018","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1600-0897.2004.00208.x","article-title":"HLA-G expression in placenta in relation to HLA-G genotype and polymorphisms","volume":"52","author":"Hviid","year":"2004","journal-title":"Am J Reprod Immunol"},{"key":"2021120808383515600_cei13134-bib-0019","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1126\/science.2326636","article-title":"A class I antigen, HLA-G, expressed in human trophoblasts","volume":"248","author":"Kovats","year":"1990","journal-title":"Science"},{"key":"2021120808383515600_cei13134-bib-0020","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.it.2017.01.009","article-title":"HLA-G: at the interface of maternal\u2013fetal tolerance","volume":"38","author":"Ferreira","year":"2017","journal-title":"Trends Immunol"},{"key":"2021120808383515600_cei13134-bib-0021","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1084\/jem.186.2.289","article-title":"Identification of a thymic epithelial cell subset sharing expression of the class Ib HLA-G molecule with fetal trophoblasts","volume":"186","author":"Crisa","year":"1997","journal-title":"J Exp Med"},{"key":"2021120808383515600_cei13134-bib-0022","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.humimm.2003.08.346","article-title":"Expression of HLA-G in human cornea, an immune-privileged tissue","volume":"64","author":"Le Discorde","year":"2003","journal-title":"Hum Immunol"},{"key":"2021120808383515600_cei13134-bib-0023","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.2337\/db05-0731","article-title":"The class I HLA repertoire of pancreatic islets comprises the nonclassical class Ib antigen HLA-G","volume":"55","author":"Cirulli","year":"2006","journal-title":"Diabetes"},{"key":"2021120808383515600_cei13134-bib-0024","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1111\/j.1600-6143.2009.02650.x","article-title":"Immunohistochemical study of HLA-G expression in lung transplant recipients","volume":"9","author":"Brugiere","year":"2009","journal-title":"Am J Transplant"},{"key":"2021120808383515600_cei13134-bib-0025","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1182\/blood-2004-03-0809","article-title":"Erythroblasts secrete the nonclassical HLA-G molecule from primitive to definitive hematopoiesis","volume":"104","author":"Menier","year":"2004","journal-title":"Blood"},{"key":"2021120808383515600_cei13134-bib-0026","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.1182\/blood-2007-12-127662","article-title":"Beyond the increasing complexity of the immunomodulatory HLA-G molecule","volume":"111","author":"Carosella","year":"2008","journal-title":"Blood"},{"key":"2021120808383515600_cei13134-bib-0027","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00018-010-0584-3","article-title":"Emerging topics and new perspectives on HLA-G","volume":"68","author":"Fainardi","year":"2011","journal-title":"Cell Mol Life Sci"},{"key":"2021120808383515600_cei13134-bib-0028","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/S0198-8859(00)00197-X","article-title":"Identification of HLA-G7 as a new splice variant of the HLA-G mRNA and expression of soluble HLA-G5, -G6, and -G7 transcripts in human transfected cells","volume":"61","author":"Paul","year":"2000","journal-title":"Hum Immunol"},{"key":"2021120808383515600_cei13134-bib-0029","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1399-0039.2006.763_5.x","article-title":"Quantification and identification of soluble HLA-G isoforms","volume":"69","author":"Rebmann","year":"2007","journal-title":"Tissue Antigens"},{"key":"2021120808383515600_cei13134-bib-0030","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.leukres.2006.06.008","article-title":"Soluble HLA revisited","volume":"31","author":"Tabayoyong","year":"2007","journal-title":"Leuk Res"},{"key":"2021120808383515600_cei13134-bib-0031","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S1471-4906(01)02007-5","article-title":"HLA-G: a shield against inflammatory aggression","volume":"22","author":"Carosella","year":"2001","journal-title":"Trends Immunol"},{"key":"2021120808383515600_cei13134-bib-0032","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.semcancer.2007.07.004","article-title":"Soluble HLA-G: are they clinically relevant?","volume":"17","author":"Pistoia","year":"2007","journal-title":"Semin Cancer Biol"},{"key":"2021120808383515600_cei13134-bib-0033","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.it.2007.11.005","article-title":"HLA-G: from biology to clinical benefits","volume":"29","author":"Carosella","year":"2008","journal-title":"Trends Immunol"},{"key":"2021120808383515600_cei13134-bib-0034","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.clim.2009.08.002","article-title":"Behavior of non-classical soluble HLA class G antigens in human immunodeficiency virus 1-infected patients before and after HAART: comparison with classical soluble HLA-A, -B, -C antigens and potential role in immune-reconstitution","volume":"133","author":"Murdaca","year":"2009","journal-title":"Clin Immunol"},{"key":"2021120808383515600_cei13134-bib-0035","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1399-0039.2009.01438.x","article-title":"Recent advances on the non-classical major histocompatibility complex class I HLA-G molecule","volume":"75","author":"Menier","year":"2010","journal-title":"Tissue Antigens"},{"key":"2021120808383515600_cei13134-bib-0036","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1177\/1352458507085137","article-title":"CSF levels of soluble HLA-G and Fas molecules are inversely associated to MRI evidence of disease activity in patients with relapsing\u2013remitting multiple sclerosis","volume":"14","author":"Fainardi","year":"2008","journal-title":"Mult Scler"},{"key":"2021120808383515600_cei13134-bib-0037","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.imlet.2011.02.011","article-title":"The tolerogenic molecule HLA-G","volume":"138","author":"Carosella","year":"2011","journal-title":"Immunol Lett"},{"key":"2021120808383515600_cei13134-bib-0038","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/10408363.2012.677947","article-title":"The immunosuppressive molecule HLA-G and its clinical implications","volume":"49","author":"Gonzalez","year":"2012","journal-title":"Crit Rev Clin Lab Sci"},{"key":"2021120808383515600_cei13134-bib-0039","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/bs.ai.2015.04.001","article-title":"HLA-G: an immune checkpoint molecule","volume":"127","author":"Carosella","year":"2015","journal-title":"Adv Immunol"},{"key":"2021120808383515600_cei13134-bib-0040","doi-asserted-by":"crossref","first-page":"11520","DOI":"10.1073\/pnas.94.21.11520","article-title":"Direct evidence to support the role of HLA-G in protecting the fetus from maternal uterine natural killer cytolysis","volume":"94","author":"Rouas-Freiss","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021120808383515600_cei13134-bib-0041","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/immu.200390015","article-title":"Soluble HLA-A,-B,-C and -G molecules induce apoptosis in T and NK CD8+ cells and inhibit cytotoxic T cell activity through CD8 ligation","volume":"33","author":"Contini","year":"2003","journal-title":"Eur J Immunol"},{"key":"2021120808383515600_cei13134-bib-0042","doi-asserted-by":"crossref","first-page":"12150","DOI":"10.1073\/pnas.201407398","article-title":"Soluble HLA-G protein secreted by allo-specific CD4+ T cells suppresses the allo-proliferative response: a CD4+ T cell regulatory mechanism","volume":"98","author":"Lila","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021120808383515600_cei13134-bib-0043","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0198-8859(03)00091-0","article-title":"Soluble HLA-G inhibits human dendritic cell-triggered allogeneic T-cell proliferation without altering dendritic differentiation and maturation processes","volume":"64","author":"Le Friec","year":"2003","journal-title":"Hum Immunol"},{"key":"2021120808383515600_cei13134-bib-0044","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.4049\/jimmunol.1300438","article-title":"Binding of HLA-G to ITIM-bearing Ig-like transcript 2 receptor suppresses B cell responses","volume":"192","author":"Naji","year":"2014","journal-title":"J Immunol"},{"key":"2021120808383515600_cei13134-bib-0045","doi-asserted-by":"crossref","first-page":"6100","DOI":"10.4049\/jimmunol.164.12.6100","article-title":"Cutting edge: soluble HLA-G1 triggers CD95\/CD95 ligand-mediated apoptosis in activated CD8+ cells by interacting with CD8","volume":"164","author":"Fournel","year":"2000","journal-title":"J Immunol"},{"key":"2021120808383515600_cei13134-bib-0046","doi-asserted-by":"crossref","first-page":"7244","DOI":"10.4049\/jimmunol.175.11.7244","article-title":"Apoptosis of antigen-specific T lymphocytes upon the engagement of CD8 by soluble HLA class I molecules is Fas ligand\/Fas mediated: evidence for the involvement of p56lck, calcium calmodulin kinase II, and Calcium-independent protein kinase C signaling pathways and for NF-kappaB and NF-AT nuclear translocation","volume":"175","author":"Contini","year":"2005","journal-title":"J Immunol"},{"key":"2021120808383515600_cei13134-bib-0047","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/molehr\/7.2.195","article-title":"Soluble HLA-G influences the release of cytokines from allogeneic peripheral blood mononuclear cells in culture","volume":"7","author":"Kanai","year":"2001","journal-title":"Mol Hum Reprod"},{"key":"2021120808383515600_cei13134-bib-0048","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.8755-8920.2001.450205.x","article-title":"Human leukocyte antigen-G-expressing cells differently modulate the release of cytokines from mononuclear cells present in the decidua versus peripheral blood","volume":"45","author":"Kanai","year":"2001","journal-title":"Am J Reprod Immunol"},{"key":"2021120808383515600_cei13134-bib-0049","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1182\/blood-2006-05-024547","article-title":"Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells","volume":"109","author":"LeMaoult","year":"2007","journal-title":"Blood"},{"key":"2021120808383515600_cei13134-bib-0050","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1182\/blood-2006-11-057125","article-title":"HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation","volume":"110","author":"Feger","year":"2007","journal-title":"Blood"},{"key":"2021120808383515600_cei13134-bib-0051","doi-asserted-by":"crossref","first-page":"6499","DOI":"10.1182\/blood-2011-07-370742","article-title":"The tolerogenic interplay(s) among HLA-G, myeloid APCs, and regulatory cells","volume":"118","author":"Carosella","year":"2011","journal-title":"Blood"},{"key":"2021120808383515600_cei13134-bib-0052","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ana.21705","article-title":"Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis","volume":"66","author":"Huang","year":"2009","journal-title":"Ann Neurol"},{"key":"2021120808383515600_cei13134-bib-0053","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.3899\/jrheum.080552","article-title":"HLA-G expression in the skin of patients with systemic sclerosis","volume":"36","author":"Wastowski","year":"2009","journal-title":"J Rheumatol"},{"key":"2021120808383515600_cei13134-bib-0054","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/cei.12633","article-title":"Clinical correlates of human leucocyte antigen (HLA)-G in systemic sclerosis","volume":"181","author":"Favoino","year":"2015","journal-title":"Clin Exp Immunol"},{"key":"2021120808383515600_cei13134-bib-0055","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"65","author":"van den Hoogen","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2021120808383515600_cei13134-bib-0056","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1399-0039.2006.00540.x","article-title":"HLA-G levels in serum and plasma","volume":"67","author":"Rudstein-Svetlicky","year":"2006","journal-title":"Tissue Antigens"},{"key":"2021120808383515600_cei13134-bib-0057","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1189\/jlb.0604337","article-title":"Recombinant HLA-G5 and -G6 drive U937 myelomonocytic cell production of TGF-beta1","volume":"76","author":"McIntire","year":"2004","journal-title":"J Leukoc Biol"},{"key":"2021120808383515600_cei13134-bib-0058","doi-asserted-by":"crossref","first-page":"125S","DOI":"10.1111\/1523-1747.ep12874998","article-title":"A possible role for transforming growth factor-beta in systemic sclerosis","volume":"95","author":"Smith","year":"1990","journal-title":"J Invest Dermatol"},{"key":"2021120808383515600_cei13134-bib-0059","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1523-1747.1998.00073.x","article-title":"Increased expression of TGF-beta receptors by scleroderma fibroblasts: evidence for contribution of autocrine TGF-beta signaling to scleroderma phenotype","volume":"110","author":"Kawakami","year":"1998","journal-title":"J Invest Dermatol"},{"key":"2021120808383515600_cei13134-bib-0060","doi-asserted-by":"crossref","first-page":"6064830","DOI":"10.1155\/2016\/6064830","article-title":"Reassessing the role of the active TGF-beta1 as a biomarker in systemic sclerosis: association of serum levels with clinical manifestations","volume":"2016","author":"Dantas","year":"2016","journal-title":"Dis Markers"},{"key":"2021120808383515600_cei13134-bib-0061","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s11926-007-0008-z","article-title":"New developments in fibroblast and myofibroblast biology: implications for fibrosis and scleroderma","volume":"9","author":"Abraham","year":"2007","journal-title":"Curr Rheumatol Rep"},{"key":"2021120808383515600_cei13134-bib-0062","first-page":"231","article-title":"Expression of HLA-G in human mononuclear phagocytes and selective induction by IFN-gamma","volume":"31","author":"Yang","year":"1996","journal-title":"J Immunol"},{"key":"2021120808383515600_cei13134-bib-0063","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1096\/fj.14-251074","article-title":"Human CD4+ HLA-G+ regulatory T cells are potent suppressors of graft-versus-host disease in vivo","volume":"28","author":"Pankratz","year":"2014","journal-title":"FASEB J"},{"key":"2021120808383515600_cei13134-bib-0064","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.humimm.2016.01.016","article-title":"CD4(+)HLA-G(+) regulatory T cells: molecular signature and pathophysiological relevance","volume":"77","author":"Pankratz","year":"2016","journal-title":"Hum Immunol"},{"key":"2021120808383515600_cei13134-bib-0065","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1189\/jlb.1RU0814-382","article-title":"CD4+\/CD8+ double-positive T cells: more than just a developmental stage?","volume":"97","author":"Overgaard","year":"2015","journal-title":"J Leukoc Biol"},{"key":"2021120808383515600_cei13134-bib-0066","first-page":"513","article-title":"Double positive CD4+CD8+ T cells: key suppressive role in the production of autoantibodies in systemic lupus erythematosus","volume":"140","author":"Wu","year":"2014","journal-title":"Indian J Med Res"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.13134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/193\/2\/152\/41645408\/cei13134.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/193\/2\/152\/41645408\/cei13134.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T04:11:11Z","timestamp":1693627871000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/193\/2\/152\/6411923"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,23]]},"references-count":66,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,5,23]]},"published-print":{"date-parts":[[2018,7,15]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.13134","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,8]]},"published":{"date-parts":[[2018,5,23]]}}}