{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:18:36Z","timestamp":1789816716461,"version":"4.0.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81372187"],"award-info":[{"award-number":["81372187"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570508"],"award-info":[{"award-number":["81570508"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470941"],"award-info":[{"award-number":["81470941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400588"],"award-info":[{"award-number":["81400588"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81741103"],"award-info":[{"award-number":["81741103"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Emerging evidence has linked the exosomes to many immunological disorders, including infectious diseases. However, knowledge regarding the role of exosomes in Helicobacter pylori infection is limited. Here, we show that serum exosomes from chronic gastritis patients with H. pylori infection (Hp exosomes) stimulate the expression of the soluble interleukin (IL)-6 receptor (sIL-6R), which is involved in IL-6 trans-signalling in gastric epithelial cells. Interestingly, sIL-6R up-regulates expression of the proinflammatory cytokine IL-1\u03b1, and the neutralization of sIL-6R suppresses IL-1\u03b1 secretion. Thus, Hp exosomes regulate IL-1\u03b1 expression via sIL-6R-mediated IL-6 trans-signaling. Altogether, this study reveals a novel perspective in which exosomes play a vital role in immunological mechanisms during H. pylori infection.<\/jats:p>","DOI":"10.1111\/cei.13200","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T03:54:22Z","timestamp":1534218862000},"page":"339-349","source":"Crossref","is-referenced-by-count":29,"title":["Serum exosomes of chronic gastritis patients infected with<i>Helicobacter pylori<\/i>mediate IL-1\u03b1 expression via IL-6 trans-signalling in gastric epithelial cells"],"prefix":"10.1093","volume":"194","author":[{"given":"Y","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,10,1]]},"reference":[{"key":"2021120808501701400_cei13200-bib-0001","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/nrc2857","article-title":"Helicobacter pylori: gastric cancer and beyond","volume":"10","author":"Polk","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"2021120808501701400_cei13200-bib-0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/hel.12250","article-title":"Epidemiology and diagnosis of Helicobacter pylori infection","volume":"20","author":"Mentis","year":"2015","journal-title":"Helicobacter"},{"key":"2021120808501701400_cei13200-bib-0003","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.advms.2014.01.003","article-title":"Seroprevalence of Helicobacter pylori infection in Polish children and adults depending on socioeconomic status and living conditions","volume":"59","author":"Laszewicz","year":"2014","journal-title":"Adv Med Sci"},{"key":"2021120808501701400_cei13200-bib-0004","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1651-2227.2009.01542.x","article-title":"Helicobacter pylori infection in children: population-based age-specific prevalence and risk factors in a developing country","volume":"99","author":"Jafri","year":"2010","journal-title":"Acta Paediatr"},{"key":"2021120808501701400_cei13200-bib-0005","first-page":"44","article-title":"Molecular epidemiology of genetic susceptibility to gastric cancer: focus on single nucleotide polymorphisms in gastric carcinogenesis","volume":"1","author":"Yin","year":"2009","journal-title":"Am J Transl Res"},{"key":"2021120808501701400_cei13200-bib-0006","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.bpg.2007.01.001","article-title":"The inflammatory and immune response to Helicobacter pylori infection","volume":"21","author":"Robinson","year":"2007","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"2021120808501701400_cei13200-bib-0007","first-page":"325","article-title":"Helicobacter pylori and extragastric diseases","volume":"400","author":"Kyburz","year":"2017","journal-title":"Curr Top Microbiol Immunol"},{"key":"2021120808501701400_cei13200-bib-0008","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.4254\/wjh.v7.i30.2968","article-title":"Extragastric manifestations of Helicobacter pylori infection: possible role of bacterium in liver and pancreas diseases","volume":"7","author":"Rabelo-Goncalves","year":"2015","journal-title":"World J Hepatol"},{"key":"2021120808501701400_cei13200-bib-0009","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/jclinpath-2012-201243","article-title":"Helicobacter pylori-associated hypochlorhydria in children, and development of iron deficiency","volume":"66","author":"Harris","year":"2013","journal-title":"J Clin Pathol"},{"key":"2021120808501701400_cei13200-bib-0010","doi-asserted-by":"crossref","first-page":"18346","DOI":"10.1038\/srep18346","article-title":"Exosomes as nanocarriers for systemic delivery of the Helicobacter pylori virulence factor CagA","volume":"6","author":"Shimoda","year":"2016","journal-title":"Sci Rep"},{"key":"2021120808501701400_cei13200-bib-0011","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2217\/nnm.15.210","article-title":"Tumor exosomes: cellular postmen of cancer diagnosis and personalized therapy","volume":"11","author":"Sharma","year":"2016","journal-title":"Nanomedicine (Lond)"},{"key":"2021120808501701400_cei13200-bib-0012","doi-asserted-by":"crossref","first-page":"44179","DOI":"10.18632\/oncotarget.6175","article-title":"Therapeutic potential of CAR-T cell-derived exosomes: a cell-free modality for targeted cancer therapy","volume":"6","author":"Tang","year":"2015","journal-title":"Oncotarget"},{"key":"2021120808501701400_cei13200-bib-0013","doi-asserted-by":"crossref","first-page":"10253","DOI":"10.18632\/oncotarget.3520","article-title":"Endothelial exosomes contribute to the antitumor response during breast cancer neoadjuvant chemotherapy via microRNA transfer","volume":"6","author":"Bovy","year":"2015","journal-title":"Oncotarget"},{"key":"2021120808501701400_cei13200-bib-0014","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1101\/pdb.top074476","article-title":"Strategies for isolation of exosomes","volume":"2015","author":"Zeringer","year":"2015","journal-title":"Cold Spring Harb Protoc"},{"key":"2021120808501701400_cei13200-bib-0015","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1242\/jcs.064386","article-title":"Microvesicles: mediators of extracellular communication during cancer progression","volume":"123","author":"Muralidharan-Chari","year":"2010","journal-title":"J Cell Sci"},{"key":"2021120808501701400_cei13200-bib-0016","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nri3622","article-title":"Regulation of immune responses by extracellular vesicles","volume":"14","author":"Robbins","year":"2014","journal-title":"Nat Rev Immunol"},{"key":"2021120808501701400_cei13200-bib-0017","first-page":"3700","article-title":"MicroRNA-155 in exosomes secreted from helicobacter pylori infection macrophages immunomodulates inflammatory response","volume":"8","author":"Wang","year":"2016","journal-title":"Am J Transl Res"},{"key":"2021120808501701400_cei13200-bib-0018","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.7150\/ijbs.4989","article-title":"IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6","volume":"8","author":"Rose-John","year":"2012","journal-title":"Int J Biol Sci"},{"key":"2021120808501701400_cei13200-bib-0019","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/cpt.782","article-title":"The soluble interleukin 6 receptor: advanced therapeutic options in inflammation","volume":"102","author":"Rose-John","year":"2017","journal-title":"Clin Pharmacol Ther"},{"key":"2021120808501701400_cei13200-bib-0020","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1111\/imr.12615","article-title":"Function and regulation of IL-1alpha in inflammatory diseases and cancer","volume":"281","author":"Malik","year":"2018","journal-title":"Immunol Rev"},{"key":"2021120808501701400_cei13200-bib-0021","doi-asserted-by":"crossref","first-page":"11794","DOI":"10.18632\/oncotarget.3649","article-title":"ERp19 contributes to tumorigenicity in human gastric cancer by promoting cell growth, migration and invasion","volume":"6","author":"Wu","year":"2015","journal-title":"Oncotarget"},{"key":"2021120808501701400_cei13200-bib-0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2017.02.002","article-title":"The role of exosomes in CNS inflammation and their involvement in multiple sclerosis","volume":"306","author":"Selmaj","year":"2017","journal-title":"J Neuroimmunol"},{"key":"2021120808501701400_cei13200-bib-0023","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: exosomes, microvesicles, and friends","volume":"200","author":"Raposo","year":"2013","journal-title":"J Cell Biol"},{"key":"2021120808501701400_cei13200-bib-0024","doi-asserted-by":"crossref","first-page":"26059","DOI":"10.1074\/jbc.M115.649509","article-title":"Shedding of endogenous interleukin-6 receptor (IL-6R) is governed by a disintegrin and metalloproteinase (ADAM) proteases while a full-length IL-6R isoform localizes to circulating microvesicles","volume":"290","author":"Schumacher","year":"2015","journal-title":"J Biol Chem"},{"key":"2021120808501701400_cei13200-bib-0025","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1242\/jcs.03372","article-title":"TACE release of TNF-alpha mediates mechanotransduction-induced activation of p38 MAPK and myogenesis","volume":"120","author":"Zhan","year":"2007","journal-title":"J Cell Sci"},{"key":"2021120808501701400_cei13200-bib-0026","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/370218a0","article-title":"Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing","volume":"370","author":"Mohler","year":"1994","journal-title":"Nature"},{"key":"2021120808501701400_cei13200-bib-0027","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Scheller","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"2021120808501701400_cei13200-bib-0028","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1128\/IAI.71.5.2693-2703.2003","article-title":"Quantitative evaluation of inflammatory and immune responses in the early stages of chronic Helicobacter pylori infection","volume":"71","author":"Straubinger","year":"2003","journal-title":"Infect Immun"},{"key":"2021120808501701400_cei13200-bib-0029","doi-asserted-by":"crossref","first-page":"463","DOI":"10.29262\/ram.v64i4.285","article-title":"Regulation of immune responses by exosomes derived from antigen presenting cells","volume":"64","author":"Maravillas-Montero","year":"2017","journal-title":"Rev Alerg Mex"},{"key":"2021120808501701400_cei13200-bib-0030","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/intimm\/dxq030","article-title":"IL-6: from its discovery to clinical applications","volume":"22","author":"Kishimoto","year":"2010","journal-title":"Int Immunol"},{"key":"2021120808501701400_cei13200-bib-0031","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1096\/fj.06-5754fje","article-title":"Sleep enhances IL-6 trans-signaling in humans","volume":"20","author":"Dimitrov","year":"2006","journal-title":"FASEB J"},{"key":"2021120808501701400_cei13200-bib-0032","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1046\/j.1365-2567.1998.00622.x","article-title":"High-level production of alternatively spliced soluble interleukin-6 receptor in serum of patients with adult T-cell leukaemia\/HTLV-I-associated myelopathy","volume":"95","author":"Horiuchi","year":"1998","journal-title":"Immunology"},{"key":"2021120808501701400_cei13200-bib-0033","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.immuni.2013.11.010","article-title":"The interleukin-1 family: back to the future","volume":"39","author":"Garlanda","year":"2013","journal-title":"Immunity"},{"key":"2021120808501701400_cei13200-bib-0034","first-page":"cm1","article-title":"Interleukin-1 (IL-1) pathway","volume":"3","author":"Weber","year":"2010","journal-title":"Sci Signal"},{"key":"2021120808501701400_cei13200-bib-0035","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.4049\/jimmunol.178.5.3059","article-title":"17beta-estradiol induces IL-1alpha gene expression in rheumatoid fibroblast-like synovial cells through estrogen receptor alpha (ERalpha) and augmentation of transcriptional activity of Sp1 by dissociating histone deacetylase 2 from ERalpha","volume":"178","author":"Itoh","year":"2007","journal-title":"J Immunol"},{"key":"2021120808501701400_cei13200-bib-0036","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.2337\/db13-1476","article-title":"Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1alpha-dependent inflammation","volume":"63","author":"Tynan","year":"2014","journal-title":"Diabetes"},{"key":"2021120808501701400_cei13200-bib-0037","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/ni.2704","article-title":"Fatty acid-induced mitochondrial uncoupling elicits inflammasome-independent IL-1alpha and sterile vascular inflammation in atherosclerosis","volume":"14","author":"Freigang","year":"2013","journal-title":"Nat Immunol"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.13200","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/194\/3\/339\/41646004\/cei13200.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/194\/3\/339\/41646004\/cei13200.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T06:01:42Z","timestamp":1720504902000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/194\/3\/339\/6411863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,1]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,10,1]]},"published-print":{"date-parts":[[2018,11,12]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.13200","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,12]]},"published":{"date-parts":[[2018,10,1]]}}}