{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:02:45Z","timestamp":1772751765556,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T00:00:00Z","timestamp":1537401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Italian Ministry of Defense","award":["D85D10000250001"],"award-info":[{"award-number":["D85D10000250001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Meningococcal polysaccharide (Men-Ps) vaccine immunogenicity following either primary immunization or revaccination in adults was evaluated. The study population consisted of subjects who have received tetravalent Men-Ps vaccine once (group 1) or at least twice, with a 2\u20136 dose range (group 2). Human leucocyte antigen (HLA)-typing was performed by polymerase chain reaction and specific immunoglobulin (Ig)G was measured by enzyme-linked immunosorbent assay. Nine months post-immunization, the percentages of individuals with levels of anti-Men-Ps IgG\u00a0\u2265\u00a02\u00a0\u00b5g\/ml were comparable in both groups, with the exception of anti-Men-PsW135 IgG, which were significantly higher in group 2. The percentage of subjects doubling IgG levels at 9\u00a0months was significantly higher in group 1. The high baseline anti-Men-Ps antibody levels negatively influenced the response to revaccination, suggesting a feedback control of specific IgG. The calculated durability of anti-Men-Ps IgG was 2\u00b75\u20134\u00b75 years, depending on the Men-Ps, following a single vaccine dose. No interference by other vaccinations nor HLA alleles association with immune response were observed. This study confirms that Men-Ps vaccine in adults is immunogenic, even when administered repeatedly, and underlines the vaccine suitability for large-scale adult immunization programmes that the higher costs of conjugate vaccines may limit in developing countries.<\/jats:p>","DOI":"10.1111\/cei.13202","type":"journal-article","created":{"date-parts":[[2018,8,12]],"date-time":"2018-08-12T15:44:00Z","timestamp":1534088640000},"page":"361-370","source":"Crossref","is-referenced-by-count":6,"title":["Immunogenicity of meningococcal polysaccharide ACWY vaccine in primary immunized or revaccinated adults"],"prefix":"10.1093","volume":"194","author":[{"given":"C","family":"Ferlito","sequence":"first","affiliation":[{"name":"Sapienza Universit\u00e0 di Roma, Dipartimento di Medicina Clinica e Molecolare, Azienda Ospedaliera Universitaria S. 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Andrea, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M S","family":"Peragallo","sequence":"additional","affiliation":[{"name":"Esercito Italiano, Centro Studi e Ricerche di Sanit\u00e0 e Veterinaria, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Lulli","sequence":"additional","affiliation":[{"name":"Sapienza Universit\u00e0 di Roma, Dipartimento di Medicina Clinica e Molecolare, Azienda Ospedaliera Universitaria S. Andrea, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Caporuscio","sequence":"additional","affiliation":[{"name":"Sapienza Universit\u00e0 di Roma, Dipartimento di Medicina Clinica e Molecolare, Azienda Ospedaliera Universitaria S. Andrea, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Autore","sequence":"additional","affiliation":[{"name":"Aeronautica Militare, Comando Logistico, Centro Sperimentale di Volo, Aeroporto Pratica di Mare, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Bizzarro","sequence":"additional","affiliation":[{"name":"Aeronautica Militare, Comando Logistico, Centro Sperimentale di Volo, Aeroporto Pratica di Mare, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Germano","sequence":"additional","affiliation":[{"name":"Sapienza Universit\u00e0 di Roma, Dipartimento di Medicina Clinica e Molecolare, Azienda Ospedaliera Universitaria S. 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