{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:17:49Z","timestamp":1777565869383,"version":"3.51.4"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for Promotion of Science","doi-asserted-by":"crossref","award":["25460523"],"award-info":[{"award-number":["25460523"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,19]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To investigate possible roles of T helper type 2 (Th2) cytokines in the anti-arthritic effects of a blood fluke, Schistosoma mansoni (Sm), for mouse collagen-induced arthritis (CIA), wild-type (WT), signal transducer and activator of transcription 6 (STAT6) knock-out (KO) and interleukin (IL)-10 KO mice were infected with Sm. Three weeks after infection, the mice were immunized with bovine type II collagen (IIC). Arthritis severity was monitored by scoring, measurement of paw thickness and the presence of ankylosis. Serum anti-IIC IgG levels, splenic cytokine production and cytokine gene expression in the popliteal lymph nodes (PLNs) were measured and compared among WT and gene-KO mice. Consistent with our previous findings, Sm infection reduced the arthritis severity in WT mice. Splenic production of IL-17A and tumor necrosis factor (TNF)-\u03b1 was reduced by the infection. In contrast, Sm infection markedly exacerbated CIA in STAT6 KO mice. In the KO mice, IL-17A production was increased by the infection. Conversely, Sm infection did not affect the exacerbated arthritis in IL-10 KO mice, although IL-17A production was reduced by the helminth. Our results suggest that signaling via STAT6 (presumably IL-4 and\/or IL-13) and IL-10 is required for the suppression of CIA by Sm infection, but through different mechanisms. STAT6 was essential for helminth-induced reduction of IL-17A, whereas regulation of the basal arthritis severity by IL-10 was needed in order for it to be sufficiently suppressed by the helminth.<\/jats:p>","DOI":"10.1111\/cei.13214","type":"journal-article","created":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T15:29:21Z","timestamp":1536420561000},"page":"109-120","source":"Crossref","is-referenced-by-count":16,"title":["STAT6 and IL-10 are required for the anti-arthritic effects of<i>Schistosoma mansoni<\/i>via different mechanisms"],"prefix":"10.1093","volume":"195","author":[{"given":"Y","family":"Osada","sequence":"first","affiliation":[{"name":"Department of Immunology and Parasitology, University of Occupational and Environmental Health, Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Horie","sequence":"additional","affiliation":[{"name":"Department of Immunology and Parasitology, University of Occupational and Environmental Health, Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Nakae","sequence":"additional","affiliation":[{"name":"Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Sudo","sequence":"additional","affiliation":[{"name":"Animal Research Center, Tokyo Medical University, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kanazawa","sequence":"additional","affiliation":[{"name":"Department of Immunology and Parasitology, University of Occupational and Environmental Health, Kitakyushu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,10,15]]},"reference":[{"key":"2022011418453457200_cei13214-bib-0001","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMra020100","article-title":"The effect of infections on susceptibility to autoimmune and allergic diseases","volume":"347","author":"Bach","year":"2002","journal-title":"N Engl J Med"},{"key":"2022011418453457200_cei13214-bib-0002","doi-asserted-by":"crossref","first-page":"J168","DOI":"10.1016\/j.jaut.2009.11.018","article-title":"Defining and analyzing geoepidemiology and human autoimmunity","volume":"34","author":"Shapira","year":"2010","journal-title":"J Autoimmun"},{"key":"2022011418453457200_cei13214-bib-0003","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1164\/rccm.200603-331OC","article-title":"Asthma and current intestinal parasite infection: systematic review and meta-analysis","volume":"174","author":"Leonardi-Bee","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"2022011418453457200_cei13214-bib-0004","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1164\/ajrccm.156.1.9606081","article-title":"Clinical improvement of asthma after anthelminthic treatment in a tropical situation","volume":"156","author":"Lynch","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"2022011418453457200_cei13214-bib-0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.exppara.2017.03.008","article-title":"Dual genetic absence of STAT6 and IL-10 does not abrogate anti-hyperglycemic effects of Schistosoma mansoni in streptozotocin-treated diabetic mice","volume":"177","author":"Osada","year":"2017","journal-title":"Exp Parasitol"},{"key":"2022011418453457200_cei13214-bib-0006","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.exppara.2013.08.003","article-title":"Heligmosomoides polygyrus infection reduces severity of type 1 diabetes induced by multiple low-dose streptozotocin in mice via STAT6- and IL-10-independent mechanisms","volume":"135","author":"Osada","year":"2013","journal-title":"Exp Parasitol"},{"key":"2022011418453457200_cei13214-bib-0007","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ijpara.2008.08.007","article-title":"Schistosoma mansoni infection reduces severity of collagen-induced arthritis via down-regulation of pro-inflammatory mediators","volume":"39","author":"Osada","year":"2009","journal-title":"Int J Parasitol"},{"key":"2022011418453457200_cei13214-bib-0008","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.parint.2014.09.001","article-title":"Reciprocal effects of Schistosoma mansoni infection on spontaneous autoimmune arthritis in IL-1 receptor antagonist-deficient mice","volume":"64","author":"Osada","year":"2015","journal-title":"Parasitol Int"},{"key":"2022011418453457200_cei13214-bib-0009","first-page":"391","article-title":"The influence of the nematode Syphacia oblevata on adjuvant arthritis in the rat","volume":"29","author":"Pearson","year":"1975","journal-title":"Immunology"},{"key":"2022011418453457200_cei13214-bib-0010","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/08916930802228290","article-title":"Spontaneous arthritis in MRL\/lpr mice is aggravated by Staphylococcus aureus and ameliorated by Nippostrongylus brasiliensis infections","volume":"42","author":"Salinas-Carmona","year":"2009","journal-title":"Autoimmunity"},{"issue":"28","key":"2022011418453457200_cei13214-bib-0011","article-title":"The inhibitory effect against collagen-induced arthritis by Schistosoma japonicum infection is infection stage-dependent","volume":"11","author":"He","year":"2010","journal-title":"BMC Immunol"},{"key":"2022011418453457200_cei13214-bib-0012","doi-asserted-by":"crossref","first-page":"e23453","DOI":"10.1371\/journal.pone.0023453","article-title":"Impact of Schistosoma japonicum infection on collagen-induced arthritis in DBA\/1 mice: a murine model of human rheumatoid arthritis","volume":"6","author":"Song","year":"2011","journal-title":"PLOS ONE"},{"key":"2022011418453457200_cei13214-bib-0013","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/intimm\/dxg012","article-title":"Immunomodulation of experimental autoimmune encephalomyelitis by helminth ova immunization","volume":"15","author":"Sewell","year":"2003","journal-title":"Int Immunol"},{"key":"2022011418453457200_cei13214-bib-0014","doi-asserted-by":"crossref","first-page":"703","DOI":"10.4049\/jimmunol.1501820","article-title":"Helminth products protect against autoimmunity via innate type 2 cytokines IL-5 and IL-33, which promote eosinophilia","volume":"196","author":"Finlay","year":"2016","journal-title":"J Immunol"},{"key":"2022011418453457200_cei13214-bib-0015","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1128\/IAI.01170-08","article-title":"Helminth infection can reduce insulitis and type 1 diabetes through CD25- and IL-10-independent mechanisms","volume":"77","author":"Liu","year":"2009","journal-title":"Infect Immun"},{"key":"2022011418453457200_cei13214-bib-0016","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/mi.2012.71","article-title":"Prevention of type 1 diabetes through infection with an intestinal nematode parasite requires IL-10 in the absence of a Th2-type response","volume":"6","author":"Mishra","year":"2013","journal-title":"Mucosal Immunol"},{"key":"2022011418453457200_cei13214-bib-0017","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1002\/art.30098","article-title":"Infection with an intestinal helminth parasite reduces Freund's complete adjuvant-induced monoarthritis in mice","volume":"63","author":"Shi","year":"2011","journal-title":"Arthritis Rheum"},{"key":"2022011418453457200_cei13214-bib-0018","doi-asserted-by":"crossref","first-page":"11596","DOI":"10.1038\/ncomms11596","article-title":"Th2 and eosinophil responses suppress inflammatory arthritis","volume":"7","author":"Chen","year":"2016","journal-title":"Nat Commun"},{"key":"2022011418453457200_cei13214-bib-0019","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/380627a0","article-title":"Essential role of Stat6 in IL-4 signalling","volume":"380","author":"Takeda","year":"1996","journal-title":"Nature"},{"key":"2022011418453457200_cei13214-bib-0020","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(93)80068-P","article-title":"Interleukin-10-deficient mice develop chronic enterocolitis","volume":"75","author":"Kuhn","year":"1993","journal-title":"Cell"},{"key":"2022011418453457200_cei13214-bib-0021","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.4049\/jimmunol.146.4.1322","article-title":"Egg deposition is the major stimulus for the production of Th2 cytokines in murine Schistosomiasis mansoni","volume":"146","author":"Grzych","year":"1991","journal-title":"J Immunol"},{"key":"2022011418453457200_cei13214-bib-0022","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.4049\/jimmunol.148.10.3264","article-title":"Infection with Schistosoma mansoni alters Th1\/Th2 cytokine responses to a non-parasite antigen","volume":"148","author":"Kullberg","year":"1992","journal-title":"J Immunol"},{"key":"2022011418453457200_cei13214-bib-0023","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.4049\/jimmunol.165.12.7240","article-title":"Evaluation of TNF-alpha and IL-1 blockade in collagen-induced arthritis and comparison with combined anti-TNF-alpha\/anti-CD4 therapy","volume":"165","author":"Williams","year":"2000","journal-title":"J Immunol"},{"key":"2022011418453457200_cei13214-bib-0024","doi-asserted-by":"crossref","first-page":"6173","DOI":"10.4049\/jimmunol.171.11.6173","article-title":"Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice","volume":"171","author":"Nakae","year":"2003","journal-title":"J Immunol"},{"key":"2022011418453457200_cei13214-bib-0025","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.4049\/jimmunol.170.5.2655","article-title":"IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand\/osteoprotegerin balance","volume":"170","author":"Lubberts","year":"2003","journal-title":"J Immunol"},{"key":"2022011418453457200_cei13214-bib-0026","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/art.20001","article-title":"Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion","volume":"50","author":"Lubberts","year":"2004","journal-title":"Arthritis Rheum"},{"key":"2022011418453457200_cei13214-bib-0027","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1084\/jem.20061775","article-title":"Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction","volume":"203","author":"Sato","year":"2006","journal-title":"J Exp Med"},{"key":"2022011418453457200_cei13214-bib-0028","doi-asserted-by":"crossref","first-page":"743758","DOI":"10.1155\/2010\/743758","article-title":"Parasitic helminths: new weapons against immunological disorders","volume":"2010","author":"Osada","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"2022011418453457200_cei13214-bib-0029","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1002\/eji.1830261020","article-title":"Attenuation of collagen-induced arthritis in mice by treatment with vector cells engineered to secrete interleukin-13","volume":"26","author":"Bessis","year":"1996","journal-title":"Eur J Immunol"},{"key":"2022011418453457200_cei13214-bib-0030","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1046\/j.1365-2249.1999.00959.x","article-title":"Encapsulation in hollow fibres of xenogeneic cells engineered to secrete IL-4 or IL-13 ameliorates murine collagen-induced arthritis (CIA)","volume":"117","author":"Bessis","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"2022011418453457200_cei13214-bib-0031","doi-asserted-by":"crossref","first-page":"5687","DOI":"10.4049\/jimmunol.159.11.5687","article-title":"Suppression of collagen-induced arthritis by continuous administration of IL-4","volume":"159","author":"Horsfall","year":"1997","journal-title":"J Immunol"},{"key":"2022011418453457200_cei13214-bib-0032","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/ar14","article-title":"Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis","volume":"1","author":"Joosten","year":"1999","journal-title":"Arthritis Res"},{"key":"2022011418453457200_cei13214-bib-0033","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/art.20107","article-title":"Plasmid encoding interleukin-4 in the amelioration of murine collagen-induced arthritis","volume":"50","author":"Kageyama","year":"2004","journal-title":"Arthritis Rheum"},{"key":"2022011418453457200_cei13214-bib-0034","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.4049\/jimmunol.166.5.3499","article-title":"Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4","volume":"166","author":"Kim","year":"2001","journal-title":"J Immunol"},{"key":"2022011418453457200_cei13214-bib-0035","doi-asserted-by":"crossref","first-page":"R18","DOI":"10.1186\/ar601","article-title":"Collagen-induced arthritis is exacerbated in IL-10-deficient mice","volume":"5","author":"Finnegan","year":"2003","journal-title":"Arthritis Res Ther"},{"key":"2022011418453457200_cei13214-bib-0036","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/j.ajpath.2012.03.010","article-title":"IL-10-producing regulatory B10 cells ameliorate collagen-induced arthritis via suppressing Th17 cell generation","volume":"180","author":"Yang","year":"2012","journal-title":"Am J Pathol"},{"key":"2022011418453457200_cei13214-bib-0037","doi-asserted-by":"crossref","first-page":"R32","DOI":"10.1186\/ar3736","article-title":"Interleukin-10 produced by B cells is crucial for the suppression of Th17\/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis","volume":"14","author":"Carter","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"2022011418453457200_cei13214-bib-0038","doi-asserted-by":"crossref","first-page":"R96","DOI":"10.1186\/ar4544","article-title":"Interleukin-10 attenuation of collagen-induced arthritis is associated with suppression of interleukin-17 and retinoid-related orphan receptor gamma T production in macrophages and repression of classically activated macrophages","volume":"16","author":"Ye","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"2022011418453457200_cei13214-bib-0039","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/eji.200535633","article-title":"Arthritis induced with cartilage-specific antibodies is IL-4-dependent","volume":"36","author":"Nandakumar","year":"2006","journal-title":"Eur J Immunol"},{"key":"2022011418453457200_cei13214-bib-0040","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1002\/1521-4141(2002010)32:10<2944::AID-IMMU2944>3.0.CO;2-4","article-title":"IL-4-deficient mice develop less acute but more chronic relapsing collagen-induced arthritis","volume":"32","author":"Svensson","year":"2002","journal-title":"Eur J Immunol"},{"key":"2022011418453457200_cei13214-bib-0041","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/clim.2000.4961","article-title":"Susceptibility to collagen-induced arthritis: cytokine-mediated regulation","volume":"98","author":"Ortmann","year":"2001","journal-title":"Clin Immunol"},{"key":"2022011418453457200_cei13214-bib-0042","doi-asserted-by":"crossref","first-page":"R158","DOI":"10.1186\/ar2838","article-title":"Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4","volume":"11","author":"Sarkar","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"2022011418453457200_cei13214-bib-0043","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/art.37805","article-title":"Type II collagen-specific antibodies induce cartilage damage in mice independent of inflammation","volume":"65","author":"Croxford","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2022011418453457200_cei13214-bib-0044","doi-asserted-by":"crossref","first-page":"R122","DOI":"10.1186\/ar2787","article-title":"Effector mechanisms of interleukin-17 in collagen-induced arthritis in the absence of interferon-gamma and counteraction by interferon-gamma","volume":"11","author":"Kelchtermans","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"2022011418453457200_cei13214-bib-0045","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1002\/1529-0131(200110)44:10<2413::AID-ART406>3.0.CO;2-E","article-title":"Genetic ablation of interferon-gamma up-regulates interleukin-1beta expression and enables the elicitation of collagen-induced arthritis in a nonsusceptible mouse strain","volume":"44","author":"Guedez","year":"2001","journal-title":"Arthritis Rheum"},{"key":"2022011418453457200_cei13214-bib-0046","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1046\/j.1365-2249.2000.01384.x","article-title":"Parasite-mediated down-regulation of collagen-induced arthritis (CIA) in DA rats","volume":"122","author":"Mattsson","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"2022011418453457200_cei13214-bib-0047","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1128\/IAI.05680-11","article-title":"Toxoplasma gondii infection inhibits Th17-mediated spontaneous development of arthritis in interleukin-1 receptor antagonist-deficient mice","volume":"80","author":"Washino","year":"2012","journal-title":"Infect Immun"},{"key":"2022011418453457200_cei13214-bib-0048","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1172\/JCI27727","article-title":"The IL-21 receptor augments Th2 effector function and alternative macrophage activation","volume":"116","author":"Pesce","year":"2006","journal-title":"J Clin Invest"},{"key":"2022011418453457200_cei13214-bib-0049","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrd4296","article-title":"Interleukin-21: a double-edged sword with therapeutic potential","volume":"13","author":"Spolski","year":"2014","journal-title":"Nat Rev Drug Discov"},{"key":"2022011418453457200_cei13214-bib-0050","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1002\/art.22452","article-title":"Blockade of the interleukin-21\/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis","volume":"56","author":"Young","year":"2007","journal-title":"Arthritis Rheum"},{"key":"2022011418453457200_cei13214-bib-0051","doi-asserted-by":"crossref","first-page":"016","DOI":"10.1186\/s13075-016-1086-y","article-title":"Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice","volume":"18","author":"Sakuraba","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"2022011418453457200_cei13214-bib-0052","doi-asserted-by":"crossref","first-page":"R49","DOI":"10.1186\/ar2960","article-title":"Interferon-gamma inhibits interleukin-1beta-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis","volume":"12","author":"Page","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"2022011418453457200_cei13214-bib-0053","doi-asserted-by":"crossref","first-page":"329","DOI":"10.4049\/jimmunol.181.1.329","article-title":"Development of proteoglycan-induced arthritis is independent of IL-17","volume":"181","author":"Doodes","year":"2008","journal-title":"J Immunol"},{"key":"2022011418453457200_cei13214-bib-0054","first-page":"943","article-title":"The pathogenesis of arthropathy in experimental schistosomiasis mansoni","volume":"30","author":"Ismail","year":"2000","journal-title":"J Egypt Soc Parasitol"},{"key":"2022011418453457200_cei13214-bib-0055","first-page":"479","article-title":"Schistosomiasis and inflammatory polyarthritis: a clinical, radiological and laboratory study of 96 patients infected by S. mansoni with particular reference to the diarthrodial joint","volume":"59","author":"Atkin","year":"1986","journal-title":"Q J Med"},{"key":"2022011418453457200_cei13214-bib-0056","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ijpara.2013.02.006","article-title":"Murine autoimmune arthritis is exaggerated by infection with the rat tapeworm","volume":"43","author":"Graepel","year":"2013","journal-title":"Int J Parasitol"},{"key":"2022011418453457200_cei13214-bib-0057","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1172\/JCI7325","article-title":"An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response","volume":"104","author":"Chiaramonte","year":"1999","journal-title":"J Clin Invest"},{"key":"2022011418453457200_cei13214-bib-0058","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1164\/rccm.201410-1820OC","article-title":"The causal role of IL-4 and IL-13 in Schistosoma mansoni pulmonary hypertension","volume":"192","author":"Kumar","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"2022011418453457200_cei13214-bib-0059","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1007\/s00436-016-5140-0","article-title":"Schistosoma japonicum cystatin attenuates murine collagen-induced arthritis","volume":"115","author":"Liu","year":"2016","journal-title":"Parasitol Res"},{"key":"2022011418453457200_cei13214-bib-0060","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.1365-3024.2010.01240.x","article-title":"rSj16, a recombinant protein of Schistosoma japonicum-derived molecule, reduces severity of the complete Freund\u2019s adjuvant-induced adjuvant arthritis in rats\u2019 model","volume":"32","author":"Sun","year":"2010","journal-title":"Parasite Immunol"},{"key":"2022011418453457200_cei13214-bib-0061","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/jcmm.12991","article-title":"Inhibition of cytokine response to TLR stimulation and alleviation of collagen-induced arthritis in mice by Schistosoma japonicum peptide SJMHE1","volume":"21","author":"Wang","year":"2017","journal-title":"J Cell Mol Med"},{"key":"2022011418453457200_cei13214-bib-0062","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/cei.12252","article-title":"Lessons from helminth infections: ES-62 highlights new interventional approaches in rheumatoid arthritis","volume":"177","author":"Pineda","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"2022011418453457200_cei13214-bib-0063","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.4049\/jimmunol.171.4.2127","article-title":"A novel therapeutic approach targeting articular inflammation using the filarial nematode-derived phosphorylcholine-containing glycoprotein ES-62","volume":"171","author":"McInnes","year":"2003","journal-title":"J Immunol"},{"key":"2022011418453457200_cei13214-bib-0064","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1002\/art.34581","article-title":"The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17-producing cellular network at multiple sites","volume":"64","author":"Pineda","year":"2012","journal-title":"Arthritis Rheum"},{"key":"2022011418453457200_cei13214-bib-0065","doi-asserted-by":"crossref","first-page":"e0165916","DOI":"10.1371\/journal.pone.0165916","article-title":"Anti-arthritic activity of Schistosoma mansoni and Trichinella spiralis derived-antigens in adjuvant arthritis in rats: role of Foxp3+ Treg cells","volume":"11","author":"Eissa","year":"2016","journal-title":"PLOS ONE"},{"key":"2022011418453457200_cei13214-bib-0066","doi-asserted-by":"crossref","first-page":"e0126429","DOI":"10.1371\/journal.pone.0126429","article-title":"Somatic antigens of tropical liver flukes ameliorate collagen-induced arthritis in Wistar rats","volume":"10","author":"Khan","year":"2015","journal-title":"PLOS ONE"},{"key":"2022011418453457200_cei13214-bib-0067","doi-asserted-by":"crossref","first-page":"e40356","DOI":"10.1371\/journal.pone.0040356","article-title":"Helminth antigens enable CpG-activated dendritic cells to inhibit the symptoms of collagen-induced arthritis through Foxp3+ regulatory T cells","volume":"7","author":"Carranza","year":"2012","journal-title":"PLOS ONE"},{"key":"2022011418453457200_cei13214-bib-0068","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1128\/IAI.01085-07","article-title":"Protective effect of an extract from Ascaris suum in experimental arthritis models","volume":"76","author":"Rocha","year":"2008","journal-title":"Infect Immun"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.13214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/chorus\/v1\/articles\/10.1111%2Fcei.13214","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/195\/1\/109\/42197199\/cei13214.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/195\/1\/109\/42197199\/cei13214.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T23:50:17Z","timestamp":1693871417000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/195\/1\/109\/6403618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,15]]},"references-count":68,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,10,15]]},"published-print":{"date-parts":[[2018,12,19]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.13214","relation":{},"ISSN":["1365-2249","0009-9104"],"issn-type":[{"value":"1365-2249","type":"electronic"},{"value":"0009-9104","type":"print"}],"subject":[],"published-other":{"date-parts":[[2019,1]]},"published":{"date-parts":[[2018,10,15]]}}}