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AID activity initially focuses on deamination of cytidine to uracil to generate somatic hypermutation and class-switch recombination of the immunoglobulin (Ig), but recently it has been implicated in DNA demethylation of genes required for B cell development and proliferation in the germinal centre (GC). However, whether AID activity on mutation or demethylation of genes involves oncogenesis of DLBCL has not been well characterized. Our data demonstrate that the proto-oncogene Fanconi anaemia complementation group A (FANCA) is highly expressed in DLBCL patients and cell lines, respectively. AID recruits demethylation enzyme ten eleven translocation family member (TET2) to bind the FANCA promoter. As a result, FANCA is demethylated and its expression increases in DLBCL. On the basis of our findings, we have developed a new therapeutic strategy to significantly inhibit DLBCL cell growth by combination of the proteasome inhibitor bortezomib with AID and TET2 depletion. These findings support a novel mechanism that AID has a crucial role in active demethylation for oncogene activation in DLBCL.<\/jats:p>","DOI":"10.1111\/cei.13227","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T11:04:40Z","timestamp":1540465480000},"page":"190-201","source":"Crossref","is-referenced-by-count":29,"title":["AID and TET2 co-operation modulates <i>FANCA<\/i> expression by active demethylation in diffuse large B cell lymphoma"],"prefix":"10.1093","volume":"195","author":[{"given":"J","family":"Jiao","sequence":"first","affiliation":[{"name":"Department of Pathogenic Biology and Immunology, School of Basic Medical Sciences, Xi\u2019an Jiaotong University Health Science Centre, Xi\u2019an, China"},{"name":"Key Laboratory of Environment and Genes Related to Diseases (Xi\u2019an Jiaotong University), Ministry of Education of China, Xi\u2019an, 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