{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:22:03Z","timestamp":1790403723206,"version":"4.1.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T00:00:00Z","timestamp":1547078400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We recently explored the expression of CXCR5 on T and B cells from peripheral blood of patients with primary Sj\u00f6gren\u2019s syndrome (SS). Here we investigated the frequency of CD25+FoxP3+CD4+ regulatory T cells (Tregs) among CXCR5+CD4+ follicular cells in the same cohort of patients. We confirm that the frequency of Tregs among follicular T cells is increased in SS patients and also provide novel data showing an increased frequency of PD-1 expressing cells among CXCR5+FoxP3+CD4+ T cells.<\/jats:p>","DOI":"10.1111\/cei.13244","type":"journal-article","created":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T09:59:50Z","timestamp":1547200790000},"page":"305-309","source":"Crossref","is-referenced-by-count":11,"title":["FoxP3+CXCR5+CD4+ T cell frequencies are increased in peripheral blood of patients with primary Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1093","volume":"195","author":[{"given":"M","family":"Ivanchenko","sequence":"first","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L A","family":"Aqrawi","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Oral Medicine, Faculty of Dentistry, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Bj\u00f6rk","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-7245","authenticated-orcid":false,"given":"M","family":"Wahren-Herlenius","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Chemin","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Medicine, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,10]]},"reference":[{"key":"2021121023225635700_cei13244-bib-0001","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/cei.13118","article-title":"Diminished CXCR1 expression in peripheral blood of patients with Sjogren\u2019s syndrome may relate to both genotype and salivary gland homing","volume":"192","author":"Aqrawi","year":"2018","journal-title":"Clin Exp Immunol"},{"key":"2021121023225635700_cei13244-bib-0002","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/art.40424","article-title":"The ratio of blood T follicular regulatory cells to T follicular helper cells marks ectopic lymphoid structure formation while activated follicular helper T cells indicate disease activity in primary Sjogren\u2019s syndrome","volume":"70","author":"Fonseca","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"2021121023225635700_cei13244-bib-0003","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1002\/art.40488","article-title":"Is the T follicular regulatory: follicular helper T cell ratio in blood a biomarker for ectopic lymphoid structure formation in Sj\u00f6gren\u2019s syndrome? Comment on the article by Fonseca et al","volume":"70","author":"Verstappen","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"2021121023225635700_cei13244-bib-0004","first-page":"2","article-title":"Human blood Tfr cells are indicators of ongoing humoral activity not fully licensed with suppressive function","author":"Fonseca","year":"2017","journal-title":"Sci Immunol"},{"key":"2021121023225635700_cei13244-bib-0005","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.immuni.2013.08.031","article-title":"Human circulating PD-1+CXCR5\u2013CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses","volume":"39","author":"Locci","year":"2013","journal-title":"Immunity"},{"key":"2021121023225635700_cei13244-bib-0006","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.immuni.2013.09.007","article-title":"Circulating precursor CCR6(lo)PD-1(hi) CXCR6(+) CD4(+) T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure","volume":"39","author":"He","year":"2013","journal-title":"Immunity"},{"key":"2021121023225635700_cei13244-bib-0007","doi-asserted-by":"crossref","first-page":"840","DOI":"10.4049\/jimmunol.177.2.840","article-title":"Regulation of trafficking receptor expression in human forkhead box P3+ regulatory T cells","volume":"177","author":"Lim","year":"2006","journal-title":"J Immunol"},{"key":"2021121023225635700_cei13244-bib-0008","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.immuni.2009.03.019","article-title":"Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor","volume":"30","author":"Miyara","year":"2009","journal-title":"Immunity"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.13244","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/195\/3\/305\/41638461\/cei13244.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/195\/3\/305\/41638461\/cei13244.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T16:25:51Z","timestamp":1641054351000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/195\/3\/305\/6403613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,10]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,1,10]]},"published-print":{"date-parts":[[2019,2,18]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.13244","relation":{},"ISSN":["1365-2249","0009-9104"],"issn-type":[{"value":"1365-2249","type":"electronic"},{"value":"0009-9104","type":"print"}],"subject":[],"published-other":{"date-parts":[[2019,3]]},"published":{"date-parts":[[2019,1,10]]}}}