{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T16:51:12Z","timestamp":1772556672544,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T00:00:00Z","timestamp":1547337600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Bundesministerum f\u00fcr Bildung und Forschung","award":["01KA1008"],"award-info":[{"award-number":["01KA1008"]}]},{"name":"Commission of the European Community FP7 Project","award":["E-PIAF #242131"],"award-info":[{"award-number":["E-PIAF #242131"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,18]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Mansonella perstans (Mp) filariasis is present in large populations in sub-Saharan Africa, and to what extent patent Mp infection modulates the expression of immunity in patients, notably their cellular cytokine and chemokine response profile, remains not well known. We studied the spontaneous and inducible cellular production of chemokines (C-X-C motif) ligand 9 (CXCL9) [monokine induced by interferon (IFN)-\u03b3 (MIG)], CXCL-10 [inducible protein (IP)-10], chemokine (C-C motif) ligand 24 (CCL24) (eotaxin-2), CCL22 [macrophage-derived chemokine (MDC)], CCL13 [monocyte chemotactic protein-4 (MCP-4)], CCL18 [pulmonary and activation-regulated chemokine (PARC)], CCL17 [thymus- and activation-regulated chemokine (TARC)] and interleukin (IL)-27 in mansonelliasis patients (Mp-PAT) and mansonelliasis-free controls (CTRL). Freshly isolated peripheral mononuclear blood cells (PBMC) were stimulated with helminth, protozoan and bacterial antigens and mitogen [phytohaemagglutinin (PHA)]. PBMC from Mp-PAT produced spontaneously (without antigen stimulation) significantly higher levels of eotaxin-2, IL-27, IL-8, MCP-4 and MDC than cells from CTRL, while IFN-\u03b3-IP-10 was lower in Mp-PAT. Helminth antigens activated IL-27 and MCP-4 only in CTRL, while Ascaris antigen, Onchocerca antigen, Schistosoma antigen, Entamoeba antigen, Streptococcus antigen, Mycobacteria antigen and PHA stimulated MIG release in CTRL and Mp-PAT. Notably, Entamoeba antigen and PHA strongly depressed (P &amp;lt; 0\u00b70001) eotaxin-2 (CCL24) production in both study groups. Multiple regression analyses disclosed in Mp-PAT and CTRL dissimilar cellular chemokine and cytokine production levels being higher in Mp-PAT for CCL24, IL-27, IL-8, MCP-4, MDC and PARC (for all P &amp;lt; 0\u00b70001), at baseline (P &amp;lt; 0\u00b70001), in response to Entamoeba histolytica strain HM1 antigen (EhAg) (P &amp;lt; 0\u00b70001), Onchocerca volvulus adult worm-derived antigen (OvAg) (P = 0\u00b7005), PHA (P &amp;lt; 0\u00b70001) and purified protein derivative (PPD) (P &amp;lt; 0\u00b70001) stimulation. In Mp-PAT with hookworm co-infection, the cellular chemokine production of CXCL10 (IP-10) was diminished. In summary, the chemokine and cytokine responses in Mp-PAT were in general not depressed, PBMC from Mp-PAT produced spontaneously and selectively inducible inflammatory and regulatory chemokines and cytokines at higher levels than CTRL and such diverse and distinctive reactivity supports that patent M. perstans infection will not polarize innate and adaptive cellular immune responsiveness in patients.<\/jats:p>","DOI":"10.1111\/cei.13251","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T16:24:22Z","timestamp":1545150262000},"page":"111-122","source":"Crossref","is-referenced-by-count":9,"title":["Inflammatory and regulatory CCL and CXCL chemokine and cytokine cellular responses in patients with patent<i>Mansonella perstans<\/i>filariasis"],"prefix":"10.1093","volume":"196","author":[{"given":"B","family":"Wangala","sequence":"first","affiliation":[{"name":"National Institute of Hygiene, Onchocerciasis Reference Laboratory, Sokod\u00e9, Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"RG","family":"Gantin","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene, Onchocerciasis Reference Laboratory, Sokod\u00e9, Togo"},{"name":"Institute of Tropical Medicine, University Clinics of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P S","family":"Vo\u00dfberg","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene, Onchocerciasis Reference Laboratory, Sokod\u00e9, Togo"},{"name":"Institute of Tropical Medicine, University Clinics of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Vovor","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Universitaire Sylvanus Olympio, Laboratory for Hematology, Universit\u00e9 de Lom\u00e9, Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WP","family":"Poutouli","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Sciences, Universit\u00e9 de Lom\u00e9, Lom\u00e9, Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Komlan","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene, Onchocerciasis Reference Laboratory, Sokod\u00e9, Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Banla","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene, Onchocerciasis Reference Laboratory, Sokod\u00e9, Togo"},{"name":"Centre Hospitalier Universitaire Campus, Universit\u00e9 de Lom\u00e9, Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine, University Clinics of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3215-7577","authenticated-orcid":false,"given":"PT","family":"Soboslay","sequence":"additional","affiliation":[{"name":"National Institute of Hygiene, Onchocerciasis Reference Laboratory, Sokod\u00e9, Togo"},{"name":"Institute of Tropical Medicine, University Clinics of T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,1,13]]},"reference":[{"key":"2021121023245392500_cei13251-bib-0001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4314\/ajid.v4i1.55085","article-title":"A systematic review of the epidemiology of mansonelliasis","volume":"4","author":"Downes","year":"2010","journal-title":"Afr J Infect Dis"},{"key":"2021121023245392500_cei13251-bib-0002","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.actatropica.2010.01.014","article-title":"Mansonella perstans filariasis in Africa","volume":"120","author":"Simonsen","year":"2011","journal-title":"Acta Trop"},{"key":"2021121023245392500_cei13251-bib-0003","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1007\/s00436-008-1312-x","article-title":"Analysis of the 24-h microfilarial periodicity of Mansonella perstans","volume":"104","author":"Asio","year":"2009","journal-title":"Parasitol Res"},{"key":"2021121023245392500_cei13251-bib-0004","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0140-6736(10)60586-7","article-title":"Lymphatic filariasis and onchocerciasis","volume":"376","author":"Taylor","year":"2010","journal-title":"Lancet"},{"key":"2021121023245392500_cei13251-bib-0005","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0035-9203(93)90504-J","article-title":"Efficacy of ivermectin in the treatment of concomitant Mansonella perstans infections in onchocerciasis patients","volume":"87","author":"Schulz-Key","year":"1993","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2021121023245392500_cei13251-bib-0006","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.parepi.2018.03.001","article-title":"Mansonella perstans, Onchocerca volvulus and Strongyloides stercoralis infections in rural populations in central and southern Togo","volume":"3","author":"Korbmacher","year":"2018","journal-title":"Parasite Epidemiol Control"},{"key":"2021121023245392500_cei13251-bib-0007","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1111\/j.1365-3156.2005.01489.x","article-title":"Short communication: Impact of long-term (14 years) bi-annual ivermectin treatment on Wuchereria bancrofti microfilaraemia","volume":"10","author":"Kyelem","year":"2005","journal-title":"Trop Med Int Health"},{"key":"2021121023245392500_cei13251-bib-0008","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.4269\/ajtmh.15-0746","article-title":"Molecular epidemiology of blood-borne human parasites in a loa loa-, Mansonella perstans-, and Plasmodium falciparum-endemic region of cameroon","volume":"94","author":"Drame","year":"2016","journal-title":"Am J Trop Med Hyg"},{"key":"2021121023245392500_cei13251-bib-0009","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.4269\/ajtmh.17-0902","article-title":"Factors associated with Wuchereria bancrofti microfilaremia in an endemic area of Mali","volume":"98","author":"Dolo","year":"2018","journal-title":"Am J Trop Med Hyg"},{"key":"2021121023245392500_cei13251-bib-0010","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1179\/136485906X112202","article-title":"Towards the elimination of onchocerciasis","volume":"100","author":"Thylefors","year":"2006","journal-title":"Ann Trop Med Parasitol"},{"key":"2021121023245392500_cei13251-bib-0011","doi-asserted-by":"crossref","first-page":"i79","DOI":"10.1093\/inthealth\/ihx044","article-title":"After 70 years of fighting an age-old scourge, onchocerciasis in Uganda, the end is in sight","volume":"10","author":"Katabarwa","year":"2018","journal-title":"Int Health"},{"key":"2021121023245392500_cei13251-bib-0012","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1179\/136485909X384929","article-title":"Mansonella perstans: Safety and efficacy of ivermectin alone, albendazole alone and the two drugs in combination","volume":"103","author":"Asio","year":"2009","journal-title":"Ann Trop Med Parasitol"},{"key":"2021121023245392500_cei13251-bib-0013","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1365-2249.1992.tb06971.x","article-title":"Ivermectin-facilitated immunity in onchocerciasis. Reversal of lymphocytopenia, cellular anergy and deficient cytokine production after single treatment","volume":"89","author":"Soboslay","year":"1992","journal-title":"Clin Exp Immunol"},{"key":"2021121023245392500_cei13251-bib-0014","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/j.1365-2249.2006.03312.x","article-title":"Onchocerca volvulus-specific antibody and cytokine responses in onchocerciasis patients after 16 years of repeated ivermectin therapy","volume":"147","author":"Mai","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"2021121023245392500_cei13251-bib-0015","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.micinf.2011.12.002","article-title":"Chemokines and cytokines in patients with an occult Onchocerca volvulus infection","volume":"14","author":"Lechner","year":"2012","journal-title":"Microbes Infect"},{"key":"2021121023245392500_cei13251-bib-0016","doi-asserted-by":"crossref","first-page":"e2679","DOI":"10.1371\/journal.pntd.0002679","article-title":"Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels","volume":"8","author":"Arndts","year":"2014","journal-title":"PLOS Negl Trop Dis"},{"key":"2021121023245392500_cei13251-bib-0017","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1186\/s13071-015-0786-5","article-title":"Reductions in microfilaridermia by repeated ivermectin treatment are associated with lower Plasmodium-specific Th17 immune responses in Onchocerca volvulus-infected individuals","volume":"8","author":"Arndts","year":"2015","journal-title":"Parasit Vectors"},{"key":"2021121023245392500_cei13251-bib-0018","doi-asserted-by":"crossref","first-page":"12526","DOI":"10.1073\/pnas.1604570113","article-title":"Community deworming alleviates geohelminth-induced immune hyporesponsiveness","volume":"113","author":"Wammes","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021121023245392500_cei13251-bib-0019","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.micinf.2005.06.019","article-title":"Cytokine and chemokine responses in patients co-infected with Entamoeba histolytica\/dispar, Necator americanus and Mansonella perstans and changes after anti-parasite treatment","volume":"8","author":"Soboslay","year":"2006","journal-title":"Microbes Infect"},{"key":"2021121023245392500_cei13251-bib-0020","first-page":"428","article-title":"Isolation of living adult Onchocerca volvulus from nodules","volume":"28","author":"Schulz-Key","year":"1977","journal-title":"Tropenmed Parasitol"},{"key":"2021121023245392500_cei13251-bib-0021","doi-asserted-by":"crossref","first-page":"e1825","DOI":"10.1371\/journal.pntd.0001825","article-title":"Proof-of-principle of onchocerciasis elimination with ivermectin treatment in endemic foci in Africa: Final results of a study in Mali and Senegal","volume":"6","author":"Traore","year":"2012","journal-title":"PLOS Negl Trop Dis"},{"key":"2021121023245392500_cei13251-bib-0022","doi-asserted-by":"crossref","first-page":"748540","DOI":"10.1155\/2012\/748540","article-title":"Transmission of onchocerciasis in wadelai focus of northwestern Uganda has been interrupted and the disease eliminated","volume":"2012","author":"Katabarwa","year":"2012","journal-title":"J Parasitol Res"},{"key":"2021121023245392500_cei13251-bib-0023","doi-asserted-by":"crossref","first-page":"e2821","DOI":"10.1371\/journal.pntd.0002821","article-title":"Interruption of infection transmission in the onchocerciasis focus of Ecuador leading to the cessation of ivermectin distribution","volume":"8","author":"Lovato","year":"2014","journal-title":"PLOS Negl Trop Dis"},{"key":"2021121023245392500_cei13251-bib-0024","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s40249-016-0160-7","article-title":"Progress towards onchocerciasis elimination in the participating countries of the African Programme for Onchocerciasis Control: epidemiological evaluation results","volume":"5","author":"Tekle","year":"2016","journal-title":"Infect Dis Poverty"},{"key":"2021121023245392500_cei13251-bib-0025","doi-asserted-by":"crossref","first-page":"e0006312","DOI":"10.1371\/journal.pntd.0006312","article-title":"Onchocerca volvulus infection and serological prevalence, ocular onchocerciasis and parasite transmission in northern and central Togo after decades of Simulium damnosum s.l. vector control and mass drug administration of ivermectin","volume":"12","author":"Komlan","year":"2018","journal-title":"PLOS Negl Trop Dis"},{"key":"2021121023245392500_cei13251-bib-0026","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1186\/s13071-016-1595-1","article-title":"Update on the distribution of Mansonella perstans in the southern part of Cameroon: Influence of ecological factors and mass drug administration with ivermectin","volume":"9","author":"Wanji","year":"2016","journal-title":"Parasit Vectors"},{"key":"2021121023245392500_cei13251-bib-0027","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.micinf.2003.11.003","article-title":"Pathogenesis and host responses in human onchocerciasis: Impact of Onchocerca filariae and Wolbachia endobacteria","volume":"6","author":"Brattig","year":"2004","journal-title":"Microbes Infect"},{"key":"2021121023245392500_cei13251-bib-0028","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/clinids\/7.6.796","article-title":"Immediate hypersensitivity responses in the immune pathogenesis of human onchocerciasis","volume":"7","author":"Ottesen","year":"1985","journal-title":"Rev Infect Dis"},{"key":"2021121023245392500_cei13251-bib-0029","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1186\/1475-2883-2-S1-S4","article-title":"Clinical picture, epidemiology and outcome of Loa-associated serious adverse events related to mass ivermectin treatment of onchocerciasis in Cameroon","volume":"24","author":"Boussinesq","year":"2003","journal-title":"Filaria J"},{"key":"2021121023245392500_cei13251-bib-0030","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1475-2883-2-S1-S5","article-title":"Possible pathogenic pathways in the adverse clinical events seen following ivermectin administration to mansonnelliasis patients","volume":"24","author":"Mackenzie","year":"2003","journal-title":"Filaria J"},{"key":"2021121023245392500_cei13251-bib-0031","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.4049\/jimmunol.127.4.1611","article-title":"Cellular killing of microfilariae of Onchocerca volvulus: Eosinophil and neutrophil-mediated immune serum-dependent destruction","volume":"127","author":"Greene","year":"1981","journal-title":"J Immunol"},{"key":"2021121023245392500_cei13251-bib-0032","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S1286-4579(01)01399-5","article-title":"Neutrophil accumulation around Onchocerca worms and chemotaxis of neutrophils are dependent on Wolbachia endobacteria","volume":"3","author":"Brattig","year":"2001","journal-title":"Microbes Infect"},{"key":"2021121023245392500_cei13251-bib-0033","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1365-2249.2005.02910.x","article-title":"Chemokines in onchocerciasis patients after a single dose of ivermectin","volume":"142","author":"Fendt","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"2021121023245392500_cei13251-bib-0034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1074-7613(01)00261-8","article-title":"Chemokines and the tissue-specific migration of lymphocytes","volume":"16","author":"Kunkel","year":"2002","journal-title":"Immunity"},{"key":"2021121023245392500_cei13251-bib-0035","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10787-013-0177-5","article-title":"The multiple faces of CCL13 in immunity and inflammation","volume":"21","author":"Mendez-Enriquez","year":"2013","journal-title":"Inflammopharmacology"},{"key":"2021121023245392500_cei13251-bib-0036","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.autrev.2012.10.001","article-title":"The interaction between CXCL10 and cytokines in chronic inflammatory arthritis","volume":"12","author":"Lee","year":"2013","journal-title":"Autoimmun Rev"},{"key":"2021121023245392500_cei13251-bib-0037","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1365-2249.2011.04474.x","article-title":"Proinflammatory and regulatory cytokines and chemokines in infants with uncomplicated and severe Plasmodium falciparum malaria","volume":"166","author":"Ayimba","year":"2011","journal-title":"Clin Exp Immunol"},{"key":"2021121023245392500_cei13251-bib-0038","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1556\/EuJMI-D-14-00041","article-title":"Chemokine levels and parasite- and allergen-specific antibody responses in children and adults with severe or uncomplicated Plasmodium falciparum malaria","volume":"5","author":"Wangala","year":"2015","journal-title":"Eur J Microbiol Immunol (Bp)"},{"key":"2021121023245392500_cei13251-bib-0039","doi-asserted-by":"crossref","first-page":"19446","DOI":"10.1073\/pnas.0706832104","article-title":"CD4+CD25+Foxp3+ regulatory T cells induce alternative activation of human monocytes\/macrophages","volume":"104","author":"Tiemessen","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021121023245392500_cei13251-bib-0040","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1007\/s00281-012-0346-4","article-title":"Immunopathogenesis of lymphatic filarial disease","volume":"34","author":"Babu","year":"2012","journal-title":"Semin Immunopathol"},{"key":"2021121023245392500_cei13251-bib-0041","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.immuni.2012.06.014","article-title":"The cytokines interleukin 27 and interferon-gamma promote distinct Treg cell populations required to limit infection-induced pathology","volume":"37","author":"Hall","year":"2012","journal-title":"Immunity"},{"key":"2021121023245392500_cei13251-bib-0042","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12950-015-0050-y","article-title":"Cellular cytokine and chemokine responses to parasite antigens and fungus and mite allergens in children co-infected with helminthes and protozoa parasites","volume":"12","author":"Hegewald","year":"2015","journal-title":"J Inflamm"},{"key":"2021121023245392500_cei13251-bib-0043","doi-asserted-by":"crossref","first-page":"e0006184","DOI":"10.1371\/journal.pntd.0006184","article-title":"Mansonella perstans microfilaremic individuals are characterized by enhanced type 2 helper T and regulatory T and B cell subsets and dampened systemic innate and adaptive immune responses","volume":"12","author":"Ritter","year":"2018","journal-title":"PLOS Negl Trop Dis"},{"key":"2021121023245392500_cei13251-bib-0044","doi-asserted-by":"crossref","first-page":"916","DOI":"10.4049\/jimmunol.0900257","article-title":"Patent filarial infection modulates malaria-specific type 1 cytokine responses in an IL-10-dependent manner in a filaria\/malaria-coinfected population","volume":"183","author":"Metenou","year":"2009","journal-title":"J Immunol"},{"key":"2021121023245392500_cei13251-bib-0045","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.4049\/jimmunol.1003778","article-title":"Filarial infection suppresses malaria-specific multifunctional Th1 and Th17 responses in malaria and filarial coinfections","volume":"186","author":"Metenou","year":"2011","journal-title":"J Immunol"},{"key":"2021121023245392500_cei13251-bib-0046","doi-asserted-by":"crossref","first-page":"e1890","DOI":"10.1371\/journal.pntd.0001890","article-title":"Filariasis attenuates anemia and proinflammatory responses associated with clinical malaria: A matched prospective study in children and young adults","volume":"6","author":"Dolo","year":"2012","journal-title":"PLOS Negl Trop Dis"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.13251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cei.13251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cei.13251","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/196\/1\/111\/41638005\/cei13251.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/196\/1\/111\/41638005\/cei13251.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T07:58:49Z","timestamp":1694505529000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/196\/1\/111\/6403595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,13]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,13]]},"published-print":{"date-parts":[[2019,3,18]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.13251","relation":{},"ISSN":["1365-2249","0009-9104"],"issn-type":[{"value":"1365-2249","type":"electronic"},{"value":"0009-9104","type":"print"}],"subject":[],"published-other":{"date-parts":[[2019,4]]},"published":{"date-parts":[[2019,1,13]]}}}