{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:51:34Z","timestamp":1769165494330,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"ZonMW-TopZorg St Antonius Care grant","award":["842002003"],"award-info":[{"award-number":["842002003"]}]},{"name":"Palacky University","award":["IGA PU LF 2017_014\/2018_015"],"award-info":[{"award-number":["IGA PU LF 2017_014\/2018_015"]}]},{"DOI":"10.13039\/501100004854","name":"St Antonius Hospital","doi-asserted-by":"crossref","award":["842002003"],"award-info":[{"award-number":["842002003"]}],"id":[{"id":"10.13039\/501100004854","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["NV18-05-00134"],"award-info":[{"award-number":["NV18-05-00134"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,16]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Genetic susceptibility for sarcoidosis and L\u00f6fgren\u2019s syndrome (LS) has been associated with prognosis. Human leukocyte antigen (HLA)-DRB1*03 is over-represented in LS, and is associated with a good prognosis, whereas HLA-DRB1*15-positive patients have a more chronic course of sarcoidosis. These HLA-DRB1 types can be easily tagged by single nucleotide polymorphisms (SNPs). Our aim was to evaluate the association between these tag SNPs and bronchoalveolar lavage (BAL) characteristics. In 29 patients, both complete HLA-DRB1* locus genotyping and SNP tagging was performed in parallel. HLA-DRB1 type was inferred from the presence of *03 tag rs2040410 allele A and referred to as *03. HLA-DRB1*15 was inferred from the presence of tag SNP rs3135388 allele A and referred to as *15. For BAL analysis, 122 patients with LS and 165 patients with non-LS sarcoidosis were included. BAL lymphocyte subsets were analyzed by flow cytometry. The presence of tag SNPs completely corresponded with HLA-DRB1*03\/*15 genotypes in all 29 patients in whom both HLA-DRB1* genotyping and SNP tagging was performed. In all patients together, *03+\/*15\u2013 patients showed a higher CD4+\/CD8+ ratio than *03\u2013\/*15+ (P = 0\u00b7004) and *03\u2013\/*15\u2013 (P = 0\u00b7001). LS patients with *03+\/*15\u2013 had a lower BAL lymphocyte count compared to *03\u2013\/*15+ patients (P = 0\u00b7011). Non-LS sarcoidosis patients with *03+\/*15\u2013 patients showed a decreased CD103+CD4+\/CD4+ ratio compared to *03\u2013\/*15+ patients (P = 0\u00b7045) and *03\u2013\/*15\u2013 patients (P = 0\u00b7018). We found that HLA-DRB1*03 and HLA-DRB1*15 can be approximated by genotyping of tag SNPs and corresponds with the degree of lymphocytosis and cell phenotypes in BAL in both LS and non-LS sarcoidosis patients.<\/jats:p>","DOI":"10.1111\/cei.13257","type":"journal-article","created":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T12:29:32Z","timestamp":1545827372000},"page":"249-258","source":"Crossref","is-referenced-by-count":12,"title":["Bronchoalveolar lavage characteristics correlate with HLA tag SNPs in patients with L\u00f6fgren\u2019s syndrome and other sarcoidosis"],"prefix":"10.1093","volume":"196","author":[{"given":"B","family":"Karakaya","sequence":"first","affiliation":[{"name":"Department of Pulmonology, ILD Center of Excellence, St Antonius Hospital, Nieuwegein, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Schimmelpennink","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, ILD Center of Excellence, St Antonius Hospital, Nieuwegein, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Kocourkova","sequence":"additional","affiliation":[{"name":"Department of Pathological Physiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"van der Vis","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, ILD Center of Excellence, St Antonius Hospital, Nieuwegein, the Netherlands"},{"name":"Department of Clinical Chemistry, ILD Center of Excellence, St Antonius Hospital, Nieuwegein, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Meek","sequence":"additional","affiliation":[{"name":"Medical Immunology and Microbiology Department, St Antonius Hospital, Nieuwegein, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J C","family":"Grutters","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, ILD Center of Excellence, St Antonius Hospital, Nieuwegein, the Netherlands"},{"name":"Division of Heart and Lungs, University Medical Center, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Petrek","sequence":"additional","affiliation":[{"name":"Department of Pathological Physiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Czech Republic"},{"name":"University Hospital Olomouc, Olomouc, the Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C H M","family":"van Moorsel","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, ILD Center of Excellence, St Antonius Hospital, Nieuwegein, the Netherlands"},{"name":"Division of Heart and Lungs, University Medical Center, Utrecht, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"2022011423224256400_cei13257-bib-0001","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.0954-6820.1952.tb13864.x","article-title":"The bilateral hilar lymphoma syndrome; a study of the relation to age and sex in 212 cases","volume":"142","author":"Lofgren","year":"1952","journal-title":"Acta Med Scand"},{"key":"2022011423224256400_cei13257-bib-0002","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.0954-6820.1952.tb13865.x","article-title":"The bilateral hilar lymphoma syndrome; a study of the relation to tuberculosis and sarcoidosis in 212 cases","volume":"142","author":"Lofgren","year":"1952","journal-title":"Acta Med Scand"},{"key":"2022011423224256400_cei13257-bib-0003","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.0954-6820.1953.tb07039.x","article-title":"Primary pulmonary sarcoidosis. 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