{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T16:14:07Z","timestamp":1764260047816,"version":"3.37.3"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LA2746\/2-0"],"award-info":[{"award-number":["LA2746\/2-0"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,14]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Infections with Schistosoma mansoni remain a major health problem in the Sudan where endemic communities, such as those in Kassala and Khartoum states, continue to face severe social\u2013economic difficulties. Our previous immunoepidemiological findings revealed different immune [cytokine and S. mansoni egg (SEA) antibody] profiles in individuals with active infections (eggs in stool n = 110), individuals positive for S. mansoni via polymerase chain reaction (PCR) using sera (SmPCR+ \u00a0n = 63) and those uninfected (Sm uninf). As antibody responses to eggs and worms are known to change during infection, we have expanded the profiling further by determining levels of adult worm (SWA) antibodies and nine chemokines in the serum of each individual in the three different cohorts. With the exception of C-C motif chemokine ligand (CCL)2, all measured chemokines were significantly higher in SmPCR+ individuals when compared to the egg+ group and in addition they also presented elevated levels of SWA-specific immunoglobulin (Ig)G2. Multivariable regression analysis further revealed that infection per se was strongly linked to SWA-specific IgG3 levels and CCL5 was strongly associated with a SmPCR+ diagnostic state. In the absence of PCR diagnostics that recognize juvenile worms or schistosomulae motives, identifying schistosome-specific traits should provide better insights into current prevalence rates in endemic communities and, in doing so, take into consideration PCR+ non-egg+ individuals in current treatment programmes.<\/jats:p>","DOI":"10.1111\/cei.13270","type":"journal-article","created":{"date-parts":[[2019,2,6]],"date-time":"2019-02-06T13:54:23Z","timestamp":1549461263000},"page":"364-373","source":"Crossref","is-referenced-by-count":2,"title":["<i>Schistosoma mansoni<\/i> PCR+-infected individuals in the Sudan present elevated systemic levels of chemokines when compared to uninfected and egg+ cohorts"],"prefix":"10.1093","volume":"196","author":[{"given":"K","family":"Arndts","sequence":"first","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital of Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T E M","family":"Elfaki","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Medical Entomology, College of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Jelden","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital of Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8667-2067","authenticated-orcid":false,"given":"M","family":"Ritter","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital of Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Wiszniewsky","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital of Bonn, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Katawa","sequence":"additional","affiliation":[{"name":"Ecole Sup\u00e9rieure des Techniques Biologiques et Alimentaires (ESTBA)\/Unit\u00e9 d'Immunologie, Universit\u00e9 de Lom\u00e9, Lome, Togo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I A","family":"Goreish","sequence":"additional","affiliation":[{"name":"Animal Resources Research Corporation, Ministry of Livestock, Fisheries and Rangelands, Khartoum, Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M E Y A","family":"Atti El Mekki","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Medical Entomology, College of Medical Laboratory Science, Sudan University of Science and Technology, Khartoum, Sudan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Doenhoff","sequence":"additional","affiliation":[{"name":"School of Life Sciences, University of Nottingham, University Park, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Hoerauf","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital of Bonn, Bonn, Germany"},{"name":"German Centre for Infection Research (DZIF), Partner Site, Bonn-Cologne, Bonn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6466-5955","authenticated-orcid":false,"given":"L E","family":"Layland","sequence":"additional","affiliation":[{"name":"Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University Hospital of Bonn, Bonn, Germany"},{"name":"German 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