{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:42:50Z","timestamp":1790660570400,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":979,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute of Health Research","doi-asserted-by":"publisher","award":["P72781"],"award-info":[{"award-number":["P72781"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013342","name":"Imperial Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"UK Medical Research Council","doi-asserted-by":"crossref","award":["MR\/K007602\/1"],"award-info":[{"award-number":["MR\/K007602\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"name":"UK Department for International Development","award":["MR\/K007602\/1"],"award-info":[{"award-number":["MR\/K007602\/1"]}]},{"name":"IMmunising PRegnant women and INfants neTwork"},{"name":"GCRF Networks in Vaccines Research and Development"},{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,24]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The maternal Tdap (tetanus, diphtheria and acellular pertussis) vaccination programme in the United Kingdom has successfully reduced cases of pertussis in young infants. In addition to prevention of pertussis cases, it is also important to investigate the persistence of maternal antibodies during infancy and the possible interference of maternal antibodies with infant responses to vaccines. We recruited mother\u2013infant pairs from vaccinated and unvaccinated pregnancies and measured concentrations of immunoglobulin (Ig)G against pertussis toxin (PTx), filamentous haemagglutinin (FHA), pertactin (Prn), diphtheria toxin (DTx), tetanus toxoid (TTx) Haemophilus influenzae type b (Hib) and Streptococcus pneumoniae in mothers and infants at birth, and in infants at 7 weeks and at 5 months. Thirty-one mother\u2013infant pairs were tested. Tdap-vaccinated women had significantly higher antibody against Tdap antigens, compared to unvaccinated women (DTx, P = 0\u00b701; PTx, FHA, Prn and TTx, P &amp;lt; 0\u00b7001). All antibodies were actively transferred to the infants (transfer ratio &amp;gt; 1) with higher transfer of DTx (P = 0\u00b704) and TTx (P = 0\u00b702) antibody in Tdap-vaccinated pregnancies compared to unvaccinated pregnancies. Infants from Tdap-vaccinated pregnancies had significantly elevated antibodies to all antigens at birth (P &amp;lt; 0.001) and at 7 weeks (FHA, Prn, TTx, P &amp;lt; 0\u00b7001; DTx, P = 0.01; PTx, P = 0\u00b7004) compared to infants from unvaccinated pregnancies. Infants from Tdap-vaccinated and -unvaccinated pregnancies had comparable antibody concentrations following primary pertussis immunization (PTx, P = 0\u00b777; FHA, P = 0\u00b758; Prn, P = 0\u00b760; DTx, P = 0\u00b709; TTx, P = 0\u00b788). These results support maternal immunization as a method of protecting vulnerable infants during their first weeks of life.<\/jats:p>","DOI":"10.1111\/cei.13275","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T19:07:22Z","timestamp":1550084842000},"page":"1-10","source":"Crossref","is-referenced-by-count":28,"title":["Antibody responses to <i>Bordetella pertussis<\/i> and other childhood vaccines in infants born to mothers who received pertussis vaccine in pregnancy \u2013 a prospective, observational cohort study from the United Kingdom"],"prefix":"10.1093","volume":"197","author":[{"given":"T F","family":"Rice","sequence":"first","affiliation":[{"name":"Section of Paediatrics, Department of Medicine, Imperial College London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Diavatopoulos","sequence":"additional","affiliation":[{"name":"Section for Pediatric Infectious Diseases, Laboratory of Medical Immunology, Radboud Institute of Molecular Life Sciences, Radboud University Medical Center , Nijmegen, the Netherlands"},{"name":"Radboud Center for Infectious Diseases, Radboud University Medical Center , Nijmegen, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G P","family":"Smits","sequence":"additional","affiliation":[{"name":"Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM) , Bilthoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P G M","family":"van Gageldonk","sequence":"additional","affiliation":[{"name":"Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM) , Bilthoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G A M","family":"Berbers","sequence":"additional","affiliation":[{"name":"Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM) , Bilthoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F R","family":"van der Klis","sequence":"additional","affiliation":[{"name":"Centre for Infectious Disease Control, National Institute of Public Health and the Environment (RIVM) , Bilthoven, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Vamvakas","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Institute of Psychology, Psychiatry and Neuroscience, King\u2019s College London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Donaldson","sequence":"additional","affiliation":[{"name":"Section of Paediatrics, Department of Medicine, Imperial College London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bouqueau","sequence":"additional","affiliation":[{"name":"Section of Paediatrics, Department of Medicine, Imperial College London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2157-9819","authenticated-orcid":false,"given":"B","family":"Holder","sequence":"additional","affiliation":[{"name":"Section of Paediatrics, Department of Medicine, Imperial College London , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6546-4709","authenticated-orcid":false,"given":"B","family":"Kampmann","sequence":"additional","affiliation":[{"name":"Section of Paediatrics, Department of Medicine, Imperial College London , UK"},{"name":"The Vaccine Centre, London School of Hygiene and Tropical Medicine , London, UK"},{"name":"Vaccines and Immunity Theme, MRC Unit The Gambia at LSHTM , Fajara, The 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