{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:48:12Z","timestamp":1792619292323,"version":"4.5.0"},"reference-count":124,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,3,11]],"date-time":"2019-03-11T00:00:00Z","timestamp":1552262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH NIAID","doi-asserted-by":"publisher","award":["R01 AI128901"],"award-info":[{"award-number":["R01 AI128901"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH NIAID","doi-asserted-by":"publisher","award":["R01AI045050"],"award-info":[{"award-number":["R01AI045050"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007820","name":"Lupus Research Alliance","doi-asserted-by":"publisher","award":["TIL-416522"],"award-info":[{"award-number":["TIL-416522"]}],"id":[{"id":"10.13039\/100007820","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,21]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Immune metabolism is a rapidly moving field. While most of the research has been conducted to define the metabolism of healthy immune cells in the mouse, it is recognized that the overactive immune system that drives autoimmune diseases presents metabolic abnormalities that provide therapeutic opportunities, as well as a means to understand the fundamental mechanisms of autoimmune activation more clearly. Here, we review recent publications that have reported how the major metabolic pathways are affected in autoimmune diseases, with a focus on rheumatic diseases.<\/jats:p>","DOI":"10.1111\/cei.13277","type":"journal-article","created":{"date-parts":[[2019,2,16]],"date-time":"2019-02-16T06:54:13Z","timestamp":1550300053000},"page":"181-192","source":"Crossref","is-referenced-by-count":33,"title":["Immune cell metabolism in autoimmunity"],"prefix":"10.1093","volume":"197","author":[{"given":"X","family":"Teng","sequence":"first","affiliation":[{"name":"Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Cornaby","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6622-1290","authenticated-orcid":false,"given":"L","family":"Morel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,11]]},"reference":[{"key":"2022021407181979000_cei13277-bib-0001","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1074-7613(02)00323-0","article-title":"The CD28 signaling pathway regulates glucose metabolism","volume":"16","author":"Frauwirth","year":"2002","journal-title":"Immunity"},{"key":"2022021407181979000_cei13277-bib-0002","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.1182\/blood-2005-12-4788","article-title":"Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth","volume":"107","author":"Doughty","year":"2006","journal-title":"Blood"},{"key":"2022021407181979000_cei13277-bib-0003","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.cell.2017.04.004","article-title":"Metabolic instruction of immunity","volume":"169","author":"Buck","year":"2017","journal-title":"Cell"},{"key":"2022021407181979000_cei13277-bib-0004","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.it.2014.12.004","article-title":"Targeting T cell metabolism for therapy","volume":"36","author":"O\u2019Sullivan","year":"2015","journal-title":"Trends Immunol"},{"key":"2022021407181979000_cei13277-bib-0005","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nrrheum.2017.54","article-title":"Fine tuning of immunometabolism for the treatment of rheumatic diseases","volume":"13","author":"Rhoads","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"2022021407181979000_cei13277-bib-0006","doi-asserted-by":"crossref","first-page":"400","DOI":"10.4049\/jimmunol.1701041","article-title":"Metabolic barriers to T cell function in tumors","volume":"200","author":"Sugiura","year":"2018","journal-title":"J Immunol"},{"key":"2022021407181979000_cei13277-bib-0007","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2016.12.039","article-title":"Understanding the intersections between metabolism and cancer biology","volume":"168","author":"Vander Heiden","year":"2017","journal-title":"Cell"},{"key":"2022021407181979000_cei13277-bib-0008","first-page":"2259","article-title":"Metabolic control of immune system activation in rheumatic diseases. 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