{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:28:30Z","timestamp":1792132110147,"version":"4.4.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":946,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006041","name":"Innovate UK","doi-asserted-by":"publisher","award":["971525"],"award-info":[{"award-number":["971525"]}],"id":[{"id":"10.13039\/501100006041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["L004291"],"award-info":[{"award-number":["L004291"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["1"],"award-info":[{"award-number":["1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["J004529"],"award-info":[{"award-number":["J004529"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["1"],"award-info":[{"award-number":["1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["CO92,"],"award-info":[{"award-number":["CO92,"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,5,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Plague caused by the Gram-negative bacterium, Yersinia pestis, is still endemic in parts of the world today. Protection against pneumonic plague is essential to prevent the development and spread of epidemics. Despite this, there are currently no licensed plague vaccines in the western world. Here we describe the means of delivering biologically active plague vaccine antigens directly to mucosal sites of plague infection using highly stable microvesicles (outer membrane vesicles; OMVs) that are naturally produced by the abundant and harmless human commensal gut bacterium Bacteroides thetaiotaomicron (Bt). Bt was engineered to express major plague protective antigens in its OMVs, specifically Fraction 1 (F1) in the outer membrane and LcrV (V antigen) in the lumen, for targeted delivery to the gastrointestinal (GI) and respiratory tracts in a non-human primate (NHP) host. Our key findings were that Bt OMVs stably expresses F1 and V plague antigens, particularly the V antigen, in the correct, immunogenic form. When delivered intranasally V-OMVs elicited substantive and specific immune and antibody responses, both in the serum [immunoglobulin (Ig)G] and in the upper and lower respiratory tract (IgA); this included the generation of serum antibodies able to kill plague bacteria. Our results also showed that Bt OMV-based vaccines had many desirable characteristics, including: biosafety and an absence of any adverse effects, pathology or gross alteration of resident microbial communities (microbiotas); high stability and thermo-tolerance; needle-free delivery; intrinsic adjuvanticity; the ability to stimulate both humoral and cell-mediated immune responses; and targeting of primary sites of plague infection.<\/jats:p>","DOI":"10.1111\/cei.13301","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T10:10:57Z","timestamp":1555323057000},"page":"287-304","source":"Crossref","is-referenced-by-count":46,"title":["Use of bioengineered human commensal gut bacteria-derived microvesicles for mucosal plague vaccine delivery and immunization"],"prefix":"10.1093","volume":"196","author":[{"given":"A L","family":"Carvalho","sequence":"first","affiliation":[{"name":"Gut Microbes and Health Research Programme, Quadram Institute Bioscience , Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Miquel-Clop\u00e9s","sequence":"additional","affiliation":[{"name":"Gut Microbes and Health Research Programme, Quadram Institute Bioscience , Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Wegmann","sequence":"additional","affiliation":[{"name":"Gut Microbes and Health Research Programme, Quadram Institute Bioscience , Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Jones","sequence":"additional","affiliation":[{"name":"Gut Microbes and Health Research Programme, Quadram Institute Bioscience , Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Stentz","sequence":"additional","affiliation":[{"name":"Gut Microbes and Health Research Programme, Quadram Institute Bioscience , Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Telatin","sequence":"additional","affiliation":[{"name":"Gut Microbes and Health Research Programme, Quadram Institute Bioscience , Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N J","family":"Walker","sequence":"additional","affiliation":[{"name":"Defence Science and Technology Laboratory , Porton, Salisbury, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W A","family":"Butcher","sequence":"additional","affiliation":[{"name":"Defence Science and Technology Laboratory , Porton, Salisbury, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Brown","sequence":"additional","affiliation":[{"name":"Public Health England, Porton , Porton, Salisbury, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Holmes","sequence":"additional","affiliation":[{"name":"Public Health England, Porton , Porton, Salisbury, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Dennis","sequence":"additional","affiliation":[{"name":"Public Health England, Porton , Porton, Salisbury, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0322-5972","authenticated-orcid":false,"given":"E D","family":"Williamson","sequence":"additional","affiliation":[{"name":"Defence Science and Technology Laboratory , Porton, Salisbury, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4254-2751","authenticated-orcid":false,"given":"S G P","family":"Funnell","sequence":"additional","affiliation":[{"name":"Public Health England, Porton , Porton, Salisbury, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Stock","sequence":"additional","affiliation":[{"name":"Plant Biotechnology Ltd , Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2383-9701","authenticated-orcid":false,"given":"S R","family":"Carding","sequence":"additional","affiliation":[{"name":"Gut Microbes and Health Research Programme, Quadram Institute Bioscience , Norwich, UK"},{"name":"Norwich Medical School, University East Anglia , Norwich, UK"},{"name":"Udo Wegmann, School of Chemistry, University East Anglia , Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"key":"2023081413140615300_cei13301-cit-0001","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.micpath.2006.09.003","article-title":"Immunogenicity of the rF1+rV vaccine for plague with identification of potential immune correlates","volume":"42","author":"Williamson","year":"2007","journal-title":"Micro Pathogen"},{"key":"2023081413140615300_cei13301-cit-0002","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/978-0-387-72124-8_35","article-title":"Cell-mediated defense against Yersinia pestis infection","volume":"603","author":"Smiley","year":"2007","journal-title":"Adv Exp Med Biol"},{"issue":"Suppl 4","key":"2023081413140615300_cei13301-cit-0003","doi-asserted-by":"crossref","first-page":"D56","DOI":"10.1016\/j.vaccine.2009.07.068","article-title":"Plague","volume":"27","author":"Williamson","year":"2009","journal-title":"Vaccine"},{"key":"2023081413140615300_cei13301-cit-0004","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1093\/infdis\/129.Supplement_1.S13","article-title":"Plague immunization. I. Past and present trends","volume":"129","author":"Meyer","year":"1974","journal-title":"J Infect Dis"},{"key":"2023081413140615300_cei13301-cit-0005","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/35097083","article-title":"Genome sequence of Yersinia pestis, the causative agent of plague","volume":"413","author":"Parkhill","year":"2001","journal-title":"Nature"},{"key":"2023081413140615300_cei13301-cit-0006","doi-asserted-by":"crossref","first-page":"817","DOI":"10.4161\/hv.9866","article-title":"Plague vaccines and the molecular basis of immunity against Yersinia pestis","volume":"5","author":"Quenee","year":"2009","journal-title":"Hum Vaccin"},{"key":"2023081413140615300_cei13301-cit-0007","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1128\/IAI.73.6.3598-3608.2005","article-title":"Human immune response to a plague vaccine comprising recombinant F1 and V antigens","volume":"73","author":"Williamson","year":"2005","journal-title":"Infect Immun"},{"key":"2023081413140615300_cei13301-cit-0008","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1586\/14787210.2013.814432","article-title":"Prophylaxis and therapy of plague","volume":"11","author":"Oyston","year":"2013","journal-title":"Expert Rev Anti Infect Ther"},{"key":"2023081413140615300_cei13301-cit-0009","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1586\/erv.09.129","article-title":"Prospects for new plague vaccines","volume":"8","author":"Feodorova","year":"2009","journal-title":"Expert Rev Vaccines"},{"key":"2023081413140615300_cei13301-cit-0010","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4103\/2230-973X.82384","article-title":"Recent trends in vaccine delivery systems: A review","volume":"1","author":"Saroja","year":"2011","journal-title":"Int J Pharm Invest"},{"key":"2023081413140615300_cei13301-cit-0011","volume-title":"WHO Target Product Profile for Plague Vaccines","author":"World Health Organization (WHO)","year":"2018"},{"key":"2023081413140615300_cei13301-cit-0012","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.vaccine.2013.11.069","article-title":"Nanoparticle vaccines","volume":"32","author":"Zhao","year":"2014","journal-title":"Vaccine"},{"key":"2023081413140615300_cei13301-cit-0013","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1586\/14760584.6.5.797","article-title":"Nanoparticles and microparticles as vaccine-delivery systems","volume":"6","author":"Singh","year":"2007","journal-title":"Expert Rev Vaccines"},{"key":"2023081413140615300_cei13301-cit-0014","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.biotechadv.2017.05.003","article-title":"Bioengineering bacterial outer membrane vesicles as vaccine platform","volume":"35","author":"Gerritzen","year":"2017","journal-title":"Biotechnol Adv"},{"key":"2023081413140615300_cei13301-cit-0015","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1365-2958.2006.05522.x","article-title":"Release of outer membrane vesicles by Gram-negative bacteria is a novel envelope stress response","volume":"63","author":"McBroom","year":"2007","journal-title":"Mol Microbiol"},{"key":"2023081413140615300_cei13301-cit-0016","doi-asserted-by":"crossref","first-page":"A23","DOI":"10.1016\/S0264-410X(02)00383-3","article-title":"Outer membrane protein A (OmpA): a new pathogen-associated molecular pattern that interacts with antigen presenting cells-impact on vaccine strategies","volume":"20","author":"Jeannin","year":"2002","journal-title":"Vaccine"},{"key":"2023081413140615300_cei13301-cit-0017","doi-asserted-by":"crossref","first-page":"7692","DOI":"10.4049\/jimmunol.179.11.7692","article-title":"Membrane vesicles are immunogenic facsimiles of Salmonella typhimurium that potently activate dendritic cells, prime B and T cell responses, and stimulate protective immunity in vivo","volume":"179","author":"Alaniz","year":"2007","journal-title":"J Immunol"},{"key":"2023081413140615300_cei13301-cit-0018","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/infdis\/146.4.568","article-title":"Pili and outer-membrane appendages on Neisseria meningitidis in the cerebrospinal fluid of an infant","volume":"146","author":"Stephens","year":"1982","journal-title":"J Infect Dis"},{"key":"2023081413140615300_cei13301-cit-0019","first-page":"7","article-title":"Gram-negative outer membrane vesicles in vaccine development","volume":"62","author":"Collins","year":"2011","journal-title":"Discov Med"},{"key":"2023081413140615300_cei13301-cit-0020","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1016\/S0264-410X(99)00423-5","article-title":"Immunogenicity and safety of a hexavalent meningococcal outer-membrane-vesicle vaccine in children of 2\u20133 and 7\u20138 years of age","volume":"18","author":"de Kleijn","year":"2000","journal-title":"Vaccine"},{"key":"2023081413140615300_cei13301-cit-0021","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1128\/CVI.00094-07","article-title":"Immunogenicity and safety of a combination of two serogroup B meningococcal outer membrane vesicle vaccines","volume":"14","author":"Sandbu","year":"2007","journal-title":"Clin Vaccine Immunol"},{"key":"2023081413140615300_cei13301-cit-0022","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri3837","article-title":"Immune modulation by bacterial outer membrane vesicles","volume":"15","author":"Kaparakis-Liaskos","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"2023081413140615300_cei13301-cit-0023","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.chom.2015.04.002","article-title":"Colitogenic Bacteroides thetaiotaomicron antigens access host immune cells in a sulfatase-dependent manner via outer membrane vesicles","volume":"17","author":"Hickey","year":"2015","journal-title":"Cell Host Microbe"},{"key":"2023081413140615300_cei13301-cit-0024","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1128\/jb.165.3.929-936.1986","article-title":"Tn4351 Transposes in Bacteroides spp. and mediates the integration of plasmid R751 into the Bacteroides chromosome","volume":"165","author":"Shoemaker","year":"1986","journal-title":"J Bacteriol"},{"key":"2023081413140615300_cei13301-cit-0025","doi-asserted-by":"crossref","first-page":"807564","DOI":"10.1155\/2014\/807564","article-title":"Efficacy of primate humoral passive transfer in a murine model of pneumonic plague is mouse strain-dependent","volume":"2014","author":"Graham","year":"2014","journal-title":"J Immunol Res"},{"key":"2023081413140615300_cei13301-cit-0026","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1128\/AEM.03086-12","article-title":"Defining the Bacteroides ribosomal binding site","volume":"79","author":"Wegmann","year":"2013","journal-title":"Appl Envir Microbio"},{"key":"2023081413140615300_cei13301-cit-0027","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/jac\/dku466","article-title":"Cephalosporinases associated with outer membrane vesicles released by Bacteroides spp. protect gut pathogens and commensals against beta-lactam antibiotics","volume":"70","author":"Stentz","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"2023081413140615300_cei13301-cit-0028","doi-asserted-by":"crossref","first-page":"15573","DOI":"10.1038\/s41598-018-33950-6","article-title":"Diversity of macaque microbiota compared to the human counterparts","volume":"8","author":"Chen","year":"2018","journal-title":"Sci Rep"},{"key":"2023081413140615300_cei13301-cit-0029","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1371\/journal.ppat.0040020","article-title":"The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis","volume":"4","author":"McKenna","year":"2008","journal-title":"PLOS Pathog"},{"key":"2023081413140615300_cei13301-cit-0030","doi-asserted-by":"crossref","first-page":"e1000546","DOI":"10.1371\/journal.pbio.1000546","article-title":"Evolutionary relationships of wild hominids recapitulated by gut microbial communities","volume":"8","author":"Ochman","year":"2010","journal-title":"PLOS Biol"},{"key":"2023081413140615300_cei13301-cit-0031","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1126\/science.aaf3951","article-title":"Cospeciation of gut microbiota with hominids","volume":"353","author":"Moeller","year":"2016","journal-title":"Science"},{"key":"2023081413140615300_cei13301-cit-0032","doi-asserted-by":"crossref","first-page":"4771","DOI":"10.1016\/j.vaccine.2011.04.084","article-title":"Recombinant (F1+V) vaccine protects cynomolgus macaques against pneumonic plague","volume":"29","author":"Williamson","year":"2011","journal-title":"Vaccine"},{"key":"2023081413140615300_cei13301-cit-0033","doi-asserted-by":"crossref","first-page":"7073","DOI":"10.1016\/j.vaccine.2009.09.061","article-title":"N255 is a key residue for recognition by a monoclonal antibody which protects against Yersinia pestis infection","volume":"27","author":"Hill","year":"2009","journal-title":"Vaccine"},{"key":"2023081413140615300_cei13301-cit-0034","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/1348-0421.12147","article-title":"V-antigen homologs in pathogenic gram-negative bacteria","volume":"58","author":"Sawa","year":"2014","journal-title":"Microbiol Immunol"},{"key":"2023081413140615300_cei13301-cit-0035","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1086\/341069","article-title":"Generation and characterization of a protective monoclonal antibody to Pseudomonas aeruginosa PcrV","volume":"186","author":"Frank","year":"2002","journal-title":"J Infect Dis"},{"key":"2023081413140615300_cei13301-cit-0036","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1086\/430932","article-title":"Protective anti-V antibodies inhibit Pseudomonas and Yersinia translocon assembly within host membranes","volume":"192","author":"Goure","year":"2005","journal-title":"J Infect Dis"},{"key":"2023081413140615300_cei13301-cit-0037","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.4161\/21645515.2014.971641","article-title":"Anti-PcrV antibody strategies against virulent Pseudomonas aeruginosa","volume":"10","author":"Sawa","year":"2014","journal-title":"Hum Vaccin Immunother"},{"key":"2023081413140615300_cei13301-cit-0038","volume-title":"Plague Outbreak Madagascar. External Situation Report. WHO","author":"World Health Organization Regional Office for Africa","year":"2017"},{"key":"2023081413140615300_cei13301-cit-0039","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1128\/IAI.01644-06","article-title":"Evaluation of the role of LcrV-Toll-like receptor 2-mediated immunomodulation in the virulence of Yersinia pestis","volume":"75","author":"Pouliot","year":"2007","journal-title":"Infect Immun"},{"key":"2023081413140615300_cei13301-cit-0040","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0264-410X(98)80110-2","article-title":"Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccine","volume":"16","author":"Heath","year":"1998","journal-title":"Vaccine"},{"key":"2023081413140615300_cei13301-cit-0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2018.06.039","article-title":"Dual route vaccination for plague with emergency use applications","author":"Moore","year":"2018","journal-title":"Vaccine"},{"key":"2023081413140615300_cei13301-cit-0042","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1517\/14712598.2011.585965","article-title":"Recombinant protein meningococcal serogroup B vaccine combined with outer membrane vesicles","volume":"11","author":"Bai","year":"2011","journal-title":"Expert Opin Biol Ther"},{"key":"2023081413140615300_cei13301-cit-0043","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0014-5793(95)00878-D","article-title":"Specific high affinity binding of human interleukin 1 beta by Caf1A usher protein of Yersinia pestis","volume":"371","author":"Zav'yalov","year":"1995","journal-title":"FEBS Lett"},{"key":"2023081413140615300_cei13301-cit-0044","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0014-5793(91)80945-Y","article-title":"Expression of the envelope antigen F1 of Yersinia pestis is mediated by the product of caf1M gene having homology with the chaperone protein PapD of Escherichia coli","volume":"286","author":"Galyov","year":"1991","journal-title":"FEBS Lett"},{"key":"2023081413140615300_cei13301-cit-0045","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1099\/jmm.0.037960-0","article-title":"The natural history and incidence of Yersinia pestis and prospects for vaccination","volume":"61","author":"Williamson","year":"2012","journal-title":"J Med Microbiol"},{"key":"2023081413140615300_cei13301-cit-0046","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.micpath.2004.06.009","article-title":"Stat 4 but not Stat 6 mediated immune mechanisms are essential in protection against plague","volume":"37","author":"Elvin","year":"2004","journal-title":"Microb Pathog"},{"key":"2023081413140615300_cei13301-cit-0047","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20010204","article-title":"Exploiting PLGA-based biocompatible nanoparticles for next-generation tolerogenic vaccines against autoimmune disease","volume":"20","author":"Cappellano","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2023081413140615300_cei13301-cit-0048","doi-asserted-by":"crossref","DOI":"10.1093\/femspd\/ftx033","article-title":"Novel approaches to Neisseria meningitidis vaccine design","volume":"75","author":"Christodoulides","year":"2017","journal-title":"Pathog Dis"},{"key":"2023081413140615300_cei13301-cit-0049","doi-asserted-by":"crossref","first-page":"24866","DOI":"10.1038\/srep24866","article-title":"Protecting enzymatic function through directed packaging into bacterial outer membrane vesicles","volume":"6","author":"Alves","year":"2016","journal-title":"Sci Rep"}],"container-title":["Clinical &amp; Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcei.13301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cei.13301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cei.13301","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/196\/3\/287\/51109524\/cei13301.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/196\/3\/287\/51109524\/cei13301.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T13:17:38Z","timestamp":1692019058000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/196\/3\/287\/6402519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,15]]},"references-count":49,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,4,15]]},"published-print":{"date-parts":[[2019,5,14]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.13301","relation":{},"ISSN":["1365-2249","0009-9104"],"issn-type":[{"value":"1365-2249","type":"electronic"},{"value":"0009-9104","type":"print"}],"subject":[],"published-other":{"date-parts":[[2019,6]]},"published":{"date-parts":[[2019,4,15]]}}}