{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:23:56Z","timestamp":1790277836426,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:00:00Z","timestamp":1555027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002657","name":"Istanbul University Research Fund","doi-asserted-by":"publisher","award":["21088"],"award-info":[{"award-number":["21088"]}],"id":[{"id":"10.13039\/501100002657","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ftirma Kurumu","doi-asserted-by":"publisher","award":["116S317"],"award-info":[{"award-number":["116S317"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002657","name":"Istanbul University","doi-asserted-by":"publisher","award":["21088"],"award-info":[{"award-number":["21088"]}],"id":[{"id":"10.13039\/501100002657","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002657","name":"Istanbul University","doi-asserted-by":"publisher","award":["116S317"],"award-info":[{"award-number":["116S317"]}],"id":[{"id":"10.13039\/501100002657","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,21]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>A small subset of myasthenia gravis (MG) patients develop autoantibodies against muscle-specific kinase (MuSK), which are predominantly of the immunoglobulin (Ig)G4 isotype. MuSK-MG is strongly associated with HLA-DRB1*14, HLA-DRB1*16 and HLA-DQB1*05. In this study, the possible effects of these HLA associations on MuSK IgG autoantibody or cytokine production were investigated. Samples from 80 MG patients with MuSK antibodies were studied. The disease-associated HLA types were screened in the DNA samples. The IgG1, IgG2, IgG3 and IgG4 titres of the MuSK antibodies and the levels of interleukin (IL)-4, IL-6, IL-17A and IL-10 were measured in the sera. Comparisons were made among the groups with or without HLA-DRB1*14, HLA-DRB1*16 or HLA-DQB1*05. The IgG4 titres of the MuSK antibodies were higher than those of the IgG1, IgG2 and IgG3 isotypes among the whole group of patients. DRB1*14 (+) DRB1*16 (\u2013) patients had higher levels of IgG4 antibodies than those of DRB1*14 (\u2013) DRB1*16 (+) patients. DRB1*14 (+) DRB1*16 (+) patients also had higher levels of IgG4 antibodies than those of DRB1*14 (\u2013) DRB1*16 (+) and DRB1*14 (\u2013) DRB1*16 (\u2013) patients. Higher IL-10 and lower IL-17A levels were measured in DRB1*14 (+) DRB1*16 (\u2013) patients than in DRB1*14 (\u2013) DRB1*16 (\u2013) patients. The higher IgG4 titres of MuSK autoantibodies in patients carrying HLA-DRB1*14 than those in the other patients suggest a role for HLA in the production of the antibodies. The differences in IL-10 and IL-17A support the role of DRB1 in the etiopathogenesis of this autoimmune response.<\/jats:p>","DOI":"10.1111\/cei.13302","type":"journal-article","created":{"date-parts":[[2019,3,31]],"date-time":"2019-03-31T04:39:15Z","timestamp":1554007155000},"page":"214-221","source":"Crossref","is-referenced-by-count":12,"title":["Relation of\n                    <i>HLA-DRB1<\/i>\n                    to IgG4 autoantibody and cytokine production in muscle-specific tyrosine kinase myasthenia gravis (MuSK-MG)"],"prefix":"10.1093","volume":"197","author":[{"given":"M","family":"\u00c7ebi","sequence":"first","affiliation":[{"name":"Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Durmu\u015f","sequence":"additional","affiliation":[{"name":"Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Y\u0131lmaz","sequence":"additional","affiliation":[{"name":"Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SP","family":"Yent\u00fcr","sequence":"additional","affiliation":[{"name":"Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Aysal","sequence":"additional","affiliation":[{"name":"Department of Neurology, Bakirkoy Research and Training Hospital for Psychiatric and Neurological Diseases, Istanbul, Turkey"},{"name":"Department of Neurology, Istanbul Medipol University School of Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Oflazer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Parman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Deymeer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6903-7173","authenticated-orcid":false,"given":"G","family":"Saruhan-Direskeneli","sequence":"additional","affiliation":[{"name":"Department of Physiology, Istanbul Medical Faculty, Istanbul University, Istanbul, 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