{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:32:47Z","timestamp":1787682767260,"version":"build-2784847793"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":917,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["IG144101"],"award-info":[{"award-number":["IG144101"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,14]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The objectives of this study were to evaluate patients with aortic abdominal aneurysm (AAA) with regard to immunoglobulin (Ig)G4-related disease (IgG4-RD). IgG4-RD represents a recently defined condition comprised of a collection of disorders characterized by IgG4 hypergammaglobulinemia, the presence of IgG4-positive plasma cells in organs affected with fibrotic or sclerotizing changes and typical histopathological features. It was identified as a possible cause of vasculitis in large vessels. Studies have been published on a possible association between inflammatory aortic or cardiovascular disease and IgG4-RD. We examined 114 patients with AAA requiring surgery in order to identify findings which are characteristic of IgG4-RD. Aneurysm samples from seven patients showed histopathological features consistent with IgG4-RD and the presence of IgG4+ plasma cells. Only two of these seven patients showed elevated IgG4 serum levels higher 1\u00b735 g\/l. In five of the patients, the concentration of serum IgG4 was lower than 1\u00b720 g\/l, with the number of IgG4+ plasma cells being higher than 50\/high-power field. These findings were consistent with AAA being a heterogeneous group of inflammatory diseases with different pathogenesis.<\/jats:p>","DOI":"10.1111\/cei.13307","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T12:45:20Z","timestamp":1556541920000},"page":"361-365","source":"Crossref","is-referenced-by-count":20,"title":["Abdominal aortic aneurysm as an IgG4-related disease"],"prefix":"10.1093","volume":"197","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3218-6586","authenticated-orcid":false,"given":"M","family":"Prucha","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry, Haematology and Immunology, Na Homolce Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Sedivy","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Na Homolce Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Stadler","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Na Homolce Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Zdrahal","sequence":"additional","affiliation":[{"name":"Department of Vascular Surgery, Na Homolce Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Prokopova","sequence":"additional","affiliation":[{"name":"Department of Pathology, Na Homolce Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Voska","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Pathology, IKEM, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Sedlackova","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Haematology and Immunology, Na Homolce Hospital, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,14]]},"reference":[{"key":"2022021407181955600_cei13307-bib-0001","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/01.cir.0000442015.53336.12","article-title":"Association Statistics Committee and Stroke Statistics Subcommittee. 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