{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:37:23Z","timestamp":1789173443148,"version":"build-2803163510"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,17]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Primary Sj\u00f6gren\u2019s syndrome (pSS) is a chronic inflammatory, autoimmune and systemic disorder commonly associated with dry eyes and a dry mouth. Recently, the hypothetical link between epithelial\u2013mesenchymal transition (EMT)-dependent salivary gland (SG) fibrosis and chronic inflammatory conditions has been suggested. In this study, we present data demonstrating a negative correlation of the epithelial marker E-cadherin expression and a positive correlation of mesenchymal vimentin and collagen type I expression with increasing degrees of tissue inflammation in pSS SG specimens. In addition, as it is not clear whether dysregulated cytokines in pSS, interleukin (IL)-17 and IL-22 may also contribute to the EMT-dependent fibrosis process, the effect of IL-17 and IL-22 treatment on EMT-dependent SG fibrosis was evaluated in primary human salivary gland epithelial cells (SGEC) isolated from healthy subjects. Here we present data demonstrating that IL-17 and IL-22 can induce SGEC to undergo a morphological and phenotypical transition to a mesenchymal phenotype. In support of this, vimentin and collagen type I were up-regulated while a decreased expression of E-cadherin occurs after interleukin treatment, and co-operation between IL-17 and Il-22 was required to induce the EMT.<\/jats:p>","DOI":"10.1111\/cei.13337","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T08:54:11Z","timestamp":1559724851000},"page":"261-272","source":"Crossref","is-referenced-by-count":50,"title":["Interleukin-17 and -22 synergy linking inflammation and EMT-dependent fibrosis in Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1093","volume":"198","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8349-1121","authenticated-orcid":false,"given":"M","family":"Sisto","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology, University of Bari \u2018Aldo Moro\u2019, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Lorusso","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology, University of Bari \u2018Aldo Moro\u2019, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Tamma","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology, University of Bari \u2018Aldo Moro\u2019, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Ingravallo","sequence":"additional","affiliation":[{"name":"Department of Emergency and Organ Transplantation (DETO), Pathology Section, University of Bari \u2018Aldo Moro\u2019, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Ribatti","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology, University of Bari \u2018Aldo Moro\u2019, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Lisi","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Sciences, Neurosciences and Sensory Organs (SMBNOS), Section of Human Anatomy and Histology, University of Bari \u2018Aldo Moro\u2019, Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,6,5]]},"reference":[{"key":"2022021406251675800_cei13337-bib-0001","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/S0003-9969(99)90008-0","article-title":"New concepts for the development of autoimmune exocrinopathy derived from studies with the NOD 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