{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:28:17Z","timestamp":1740126497459,"version":"3.37.3"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T00:00:00Z","timestamp":1561852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2019MH099","ZR2015HM031","ZR2016HB25"],"award-info":[{"award-number":["ZR2019MH099","ZR2015HM031","ZR2016HB25"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81600348","81600695"],"award-info":[{"award-number":["81600348","81600695"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003091","name":"Shandong Province","doi-asserted-by":"publisher","award":["2018WS534","2016WS0748"],"award-info":[{"award-number":["2018WS534","2016WS0748"]}],"id":[{"id":"10.13039\/501100003091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>A20, a pivotal anti-inflammatory protein, preserves immune homeostasis and regulates prolonged inflammation. A previous study has shown that A20 expression levels are down-regulated in peripheral blood mononuclear cells (PBMCs) from patients with ankylosing spondylitis (AS). However, the precise role of A20 in reducing autoimmune disorders needs to be further elucidated. In this study, A20 expression was found to be preferentially reduced on circulating CD56bright natural killer (NK) cells in patients with AS, and its level was negatively correlated with that of proinflammatory cytokines. Further investigation demonstrated that A20 reduces interferon (IFN)-\u03b3 and tumour necrosis factor (TNF)-\u03b1 production in CD56bright NK cells after stimulation with monokines or phorbol myristate acetate (PMA)\/ionomycin(P\/I). Furthermore, CD56bright NK cells isolated from AS patients promote TNF-\u03b1 secretion by autologous monocytes, and increasing the A20 expression level partially attenuates this process. More importantly, decreased A20 expression on circulating CD56bright NK cells is associated with worse disease status in patients with AS. Our findings reveal that A20 participates in the pathogenesis of AS by negatively regulating CD56bright NK cells and that its reduced expression contributes to a worsened disease status in patients with AS.<\/jats:p>","DOI":"10.1111\/cei.13341","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T15:42:40Z","timestamp":1560786160000},"page":"1-10","source":"Crossref","is-referenced-by-count":8,"title":["Decreased A20 expression on circulating CD56bright NK cells contributes to a worse disease status in patients with ankylosing spondylitis"],"prefix":"10.1093","volume":"198","author":[{"given":"M","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University , Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Binzhou Medical University Hospital , Binzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Liu","sequence":"additional","affiliation":[{"name":"Center of Translational Medicine, Zibo Central Hospital Affiliated to Shandong University , Zibo, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Zibo Central Hospital Affiliated to Shandong University , Zibo, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University , Yantai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q","family":"Shang","sequence":"additional","affiliation":[{"name":"Center of Translational Medicine, Zibo Central Hospital Affiliated to Shandong University , Zibo, 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