{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:28:18Z","timestamp":1740126498857,"version":"3.37.3"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472311","81570501","81770554","81772607"],"award-info":[{"award-number":["81472311","81570501","81770554","81772607"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,17]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Fecal calprotectin has successfully been widely recommended as a sensitive biomarker of inflammatory bowel diseases (IBD). Recently, we have identified an excellent new fecal biomarker, B cell activating factor (BAFF), as being as effective as fecal calprotectin for diagnosing intestinal inflammation. In this study, a total of 230 patients with abdominal discomfort were prospectively enrolled and fecal samples were collected within 24 h before the endoscopic examinations. We show that fecal BAFF levels were significantly higher in patients with ulcerative colitis (median = 1549 pg\/g, P &amp;lt; 0\u00b70001), Crohn\u2019s disease (median = 735 pg\/g, P &amp;lt; 0\u00b70001), gastric cancer (median = 267 pg\/g, P &amp;lt; 0\u00b70001) and colorectal cancer (median = 533 pg\/g, P &amp;lt; 0\u00b70001) than those in healthy groups (median = 61 pg\/g), while the values of which in patients with gastric polyps, colorectal polyps, esophagitis\/gastritis\/duodenitis and peptic ulcer were in the range of healthy individuals (P &amp;gt; 0\u00b705). An optimal cut-off value at 219\u00b75 pg\/g of fecal BAFF produced sensitivity, specificity, positive predictive and negative predictive values of 85, 91, 84 and 92%, respectively, for IBD or carcinoma. Our results therefore indicate a potential role for fecal BAFF as a sensitive screening parameter for IBD and gastrointestinal carcinoma, as well a useful tool to select patients with abdominal discomfort for further endoscopic examinations.<\/jats:p>","DOI":"10.1111\/cei.13350","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T20:22:55Z","timestamp":1563394975000},"page":"131-140","source":"Crossref","is-referenced-by-count":4,"title":["Diagnostic value of fecal B cell activating factor in patients with abdominal discomfort"],"prefix":"10.1093","volume":"198","author":[{"given":"C","family":"Xie","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Quan","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8878-3131","authenticated-orcid":false,"given":"Y","family":"Fu","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,8,5]]},"reference":[{"key":"2023081413140079400_cei13350-cit-0001","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/ije\/22.6.1093","article-title":"Abdominal symptom associations in a longitudinal study","volume":"22","author":"Kay","year":"1993","journal-title":"Int J Epidemiol"},{"key":"2023081413140079400_cei13350-cit-0002","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/0895-4356(92)90199-W","article-title":"Schultz-Larsen K. 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