{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:56:38Z","timestamp":1790506598938,"version":"4.1.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T00:00:00Z","timestamp":1566777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Science and Technology Specific Program of Guangzhou Science and Innovation Commission","award":["201607020046"],"award-info":[{"award-number":["201607020046"]}]},{"name":"Major Research Plan of NSFC-Guangdong Joint Project","award":["U1801286"],"award-info":[{"award-number":["U1801286"]}]},{"DOI":"10.13039\/100008582","name":"McGill University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008582","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,15]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>The prevalence of allergic asthma and incidences of helminth infections in humans are inversely correlated. Although experimental studies have established the causal relation between parasite infection and allergic asthma, the mechanism of the parasite-associated immunomodulation is not fully elucidated. Using a murine model of asthma and nematode parasite Heligmosomoides polygyrus, we investigated the roles of regulatory B cells (Breg) and T cells (Treg) in mediation of the protection against allergic asthma by parasite. H. polygyrus infection significantly suppressed ovalbumin (OVA)-induced allergic airway inflammation (AAI) evidenced by alleviated lung histopathology and reduced numbers of bronchoalveolar inflammatory cell infiltration, and induced significant responses of interleukin (IL)-10+ Breg, IL-10+ Treg and forkhead box protein 3 (FoxP3)+ Treg in mesenteric lymph node and spleen of the mice. Adoptive transfer of IL-10+ Breg and IL-10+ Treg cell prevented the lung immunopathology in AAI mice. Depletion of FoxP3+ Treg cells in FoxP3-diphtheria toxin (DT) receptor transgenic mice by diphtheria toxin (DT) treatment exacerbated airway inflammation in parasite-free AAI mice and partially abrogated the parasite-induced protection against AAI. IL-10+ Breg cells were able to promote IL-10+ Treg expansion and maintain FoxP3+ Treg cell population. These two types of Tregs failed to induce CD19+ B cells to transform into IL-10+ Breg cells. These results demonstrate that Breg, IL-10+ Treg and FoxP3+ Treg cells contribute in A discrepant manner to the protection against allergic airway immunopathology by parasiteS. Breg cell might be a key upstream regulatory cell that induces IL-10+ Treg response and supports FoxP3+ Treg cell population which, in turn, mediate the parasite-imposed immunosuppression of allergic airway inflammation. These results provide insight into the immunological relationship between parasite infection and allergic asthma.<\/jats:p>","DOI":"10.1111\/cei.13362","type":"journal-article","created":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T11:18:09Z","timestamp":1565349489000},"page":"390-402","source":"Crossref","is-referenced-by-count":42,"title":["Critical roles of regulatory B and T cells in helminth parasite-induced protection against allergic airway inflammation"],"prefix":"10.1093","volume":"198","author":[{"given":"X","family":"Gao","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Q","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Public Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5522-9679","authenticated-orcid":false,"given":"Z","family":"Su","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,8,26]]},"reference":[{"key":"2022011418365535200_cei13362-bib-0001","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1111\/pai.12272","article-title":"Allergy and asthma prevention 2014","volume":"25","author":"Nieto","year":"2014","journal-title":"Pediatr Allergy Immunol"},{"key":"2022011418365535200_cei13362-bib-0002","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMra020100","article-title":"The effect of infections on susceptibility to autoimmune and allergic diseases","volume":"347","author":"Bach","year":"2002","journal-title":"N Engl J Med"},{"key":"2022011418365535200_cei13362-bib-0003","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1056\/NEJMra054308","article-title":"The asthma epidemic","volume":"355","author":"Eder","year":"2006","journal-title":"N Engl J Med"},{"key":"2022011418365535200_cei13362-bib-0004","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nri.2017.111","article-title":"The hygiene hypothesis in autoimmunity: the role of pathogens and commensals","volume":"18","author":"Bach","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"2022011418365535200_cei13362-bib-0005","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.jaci.2016.07.007","article-title":"Regulation of the host immune system by helminth parasites","volume":"138","author":"Maizels","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"2022011418365535200_cei13362-bib-0006","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1067\/mai.2003.1381","article-title":"Schistosoma mansoni infection is associated with a reduced course of asthma","volume":"111","author":"Medeiros","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"2022011418365535200_cei13362-bib-0007","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.3109\/02770903.2014.936454","article-title":"Reduced asthma morbidity in endemic areas for helminth infections: a longitudinal ecological study in Brazil","volume":"51","author":"Ponte","year":"2014","journal-title":"J Asthma"},{"key":"2022011418365535200_cei13362-bib-0008","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1164\/rccm.200603-331OC","article-title":"Collaboration PiA. 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