{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:11:29Z","timestamp":1789647089114,"version":"4.0.0"},"reference-count":170,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Women who conceive at 35 years of age or older, commonly known as advanced maternal age, have a higher risk of facing parturition complications and their children have an increased risk of developing diseases later in life. However, the immunological mechanisms underlying these pathological processes have yet to be established. To fill this gap in knowledge, using a murine model and immunophenotyping, we determined the effect of advanced maternal age on the main cellular branch of adaptive immunity, T cells, at the maternal\u2013fetal interface and in the offspring. We report that advanced maternal age impaired the process of labor at term, inducing dystocia and delaying the timing of delivery. Advanced maternal age diminished the number of specific proinflammatory T-cell subsets [T helper type 1 (Th1): CD4+IFN-\u03b3+, CD8+IFN-\u03b3+ and Th9: CD4+IL-9+], as well as CD4+ regulatory T cells (CD4+CD25+FoxP3+ T cells), at the maternal\u2013fetal interface prior to term labor. Advanced maternal age also altered fetal growth and survival of the offspring in early life. In addition, infants born to advanced-age mothers had alterations in the T-cell repertoire but not in CD71+ erythroid cells (CD3\u2212CD71+TER119+ cells). This study provides insight into the immune alterations observed at the maternal\u2013fetal interface of advanced-age mothers and their offspring.<\/jats:p>","DOI":"10.1111\/cei.13437","type":"journal-article","created":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T03:24:56Z","timestamp":1586661896000},"page":"58-75","source":"Crossref","is-referenced-by-count":23,"title":["The effects of advanced maternal age on T-cell subsets at the maternal\u2013fetal interface prior to term labor and in the offspring: a mouse study"],"prefix":"10.1093","volume":"201","author":[{"given":"D","family":"Levenson","sequence":"first","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal\u2013Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Romero","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal\u2013Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA"},{"name":"Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA"},{"name":"Detroit Medical Center, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Garcia-Flores","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal\u2013Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Miller","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal\u2013Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Xu","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal\u2013Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Sahi","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal\u2013Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S S","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"},{"name":"Office of Women's Health, Integrative Biosciences Center, Wayne State University, Detroit, MI, USA"},{"name":"Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3406-5262","authenticated-orcid":false,"given":"N","family":"Gomez-Lopez","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal\u2013Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, US Department of Health and Human Services, Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"},{"name":"Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"2021121023183245400_cei13437-bib-0001","doi-asserted-by":"crossref","DOI":"10.18356\/8344d573-en","volume-title":"World Fertility Report 2015","author":"United Nations","year":"2017"},{"key":"2021121023183245400_cei13437-bib-0002","first-page":"1","article-title":"Births: final data for 2016","volume":"67","author":"Martin","year":"2018","journal-title":"Natl Vital Stat Rep"},{"key":"2021121023183245400_cei13437-bib-0003","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1136\/bmj.38380.674340.E0","article-title":"Risk factors for pre-eclampsia at antenatal booking: 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