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Here, we investigated the involvement of 21\u00a0single nucleotide polymorphisms (SNPs) of immunorelated genes, including cytokines [interleukin (IL)-2, IL-4,\u00a0IL-9, IL-12A, IL-22, interferon (IFN-\u03b1) and transforming growth factor (TGF)-\u03b21], transcriptional regulatory genes (TBX21, STAT1, STAT3, STAT5B, STAT6, GATA3, FOXP3 and IRF4)\u00a0and others (IL2RA,\u00a0IL6R, NFKBIA) in 269 AML in-patients and 200 healthy controls. Furthermore, we analyzed the relationship between the SNPs and clinical characteristics. Immunorelated SNP genotyping was performed on the Sequenom MassARRAY iPLEX platform. All the SNPs in healthy controls were consistent with Hardy\u2013Weinberg equilibrium. All final P-values were adjusted by Bonferroni multiple testing. Our results showed that IL-22 (rs2227491) was significantly associated with the white blood cell (WBC) counts. Signal transducer and activator of transcription 5B (STAT-5B) (rs6503691) showed a close relationship with the recurrent genetic abnormalities in patients with AML. We verified the negatively independent effect of age and risk of cytogenetics on overall survival (OS). More importantly, the GG genotype of IL-12A (rs6887695) showed a negative impact on AML prognosis independently. Furthermore, the relative expression of IL-12 was decreased in GG genotype, no matter under a co-dominant or recessive model. However, no correlation was observed between the SNPs mentioned above and disease susceptibility, risk stratification and survival. Our findings suggest that immunorelated gene polymorphisms are associated with prognosis in AML, which may perform as novel inspection targets for AML patients.<\/jats:p>","DOI":"10.1111\/cei.13446","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T22:36:52Z","timestamp":1588199812000},"page":"266-278","source":"Crossref","is-referenced-by-count":14,"title":["Immunorelated gene polymorphisms associated with acute myeloid leukemia"],"prefix":"10.1093","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4264-0818","authenticated-orcid":false,"given":"Q","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology, Qilu Hospital, Shandong University, Jinan, China"},{"name":"Department of Hematology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China"},{"name":"Department of Hematology, Taian Central Hospital, Taian, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Hematology, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Hematology, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Hematology, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Hematology, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0664-8441","authenticated-orcid":false,"given":"D","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Hematology, Qilu Hospital, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"2021121023212631700_cei13446-bib-0001","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra1406184","article-title":"Acute myeloid leukemia","volume":"373","author":"D\u00f6hner","year":"2015","journal-title":"N Engl J Med"},{"key":"2021121023212631700_cei13446-bib-0002","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/ejh.13172","article-title":"Clinical implications of molecular markers in acute myeloid leukemia","volume":"102","author":"Kayser","year":"2019","journal-title":"Eur J Haematol"},{"key":"2021121023212631700_cei13446-bib-0003","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","article-title":"Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia","volume":"368","author":"Cancer Genome Atlas Research N","year":"2013","journal-title":"N Engl J Med"},{"key":"2021121023212631700_cei13446-bib-0004","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.drudis.2018.05.040","article-title":"Advances in treatment formulations for acute myeloid leukemia","volume":"23","author":"Briot","year":"2018","journal-title":"Drug Discov Today"},{"key":"2021121023212631700_cei13446-bib-0005","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1126\/science.1190310","article-title":"Immunology. 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