{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T08:25:35Z","timestamp":1758702335327,"version":"3.37.3"},"reference-count":72,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":520,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Children diagnosed with a combination of type 1 diabetes (T1D) and celiac disease (CD) show a dysregulated T helper type 1 (Th1)\/Th17 response. Besides the cellular involvement, several soluble immune markers are involved in the autoimmune process of both T1D and CD. Only few studies have examined the peripheral pattern of different cytokines, chemokines and acute-phase proteins (APP) in children with combined T1D and CD. To our knowledge, no studies have evaluated the serum levels of adipocytokines and matrix metalloproteinases (MMPs) in this context. The purpose of the present study was to acquire more knowledge and to gain deeper understanding regarding the peripheral immunoregulatory milieu in children with both T1D and CD. The study included children diagnosed with both T1D and CD (n\u00a0=\u00a018), children with T1D (n\u00a0=\u00a027) or CD (n\u00a0=\u00a016) and reference children (n\u00a0=\u00a042). Sera were collected and analysis of 28\u00a0immune markers (cytokines, chemokines, APPs, adipocytokines and MMPs) was performed using the Luminex technique. The major findings showed that children with a double diagnosis had lower serum levels of interleukin (IL)-22, monocyte chemoattractant protein (MIP)-1\u03b1, monocyte chemoattractant protein (MCP)-1, procalcitonin, fibrinogen, visfatin and matrix metalloproteinase (MMP)-2. These results indicate a suppressed immune profile in children with combined T1D and CD, including Th17 cytokines, chemokines, APPs, adipocytokines and MMPs. We conclude that, besides cytokines and chemokines, other immune markers, e.g. APPs, adipocytokines and MMPs, are of importance for further investigations to elucidate the heterogeneous immune processes present in patients diagnosed with T1D in combination with CD.<\/jats:p>","DOI":"10.1111\/cei.13454","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T20:00:47Z","timestamp":1589659247000},"page":"244-257","source":"Crossref","is-referenced-by-count":6,"title":["Suppressed immune profile in children with combined type 1 diabetes and celiac disease"],"prefix":"10.1093","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7995-3546","authenticated-orcid":false,"given":"A","family":"Tompa","sequence":"first","affiliation":[{"name":"The Biomedical platform, Department of Natural Science and Biomedicine, School of Health and Welfare, J\u00f6nk\u00f6ping University, J\u00f6nk\u00f6ping, Sweden"},{"name":"Division of Diagnostics, Region J\u00f6nk\u00f6ping County, J\u00f6nk\u00f6ping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2556-5094","authenticated-orcid":false,"given":"K","family":"\u00c5kesson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ryhov County Hospital, J\u00f6nk\u00f6ping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6364-3850","authenticated-orcid":false,"given":"S","family":"Karlsson","sequence":"additional","affiliation":[{"name":"The Biomedical platform, Department of Natural Science and Biomedicine, School of Health and Welfare, J\u00f6nk\u00f6ping University, J\u00f6nk\u00f6ping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9385-6825","authenticated-orcid":false,"given":"M","family":"Faresj\u00f6","sequence":"additional","affiliation":[{"name":"The Biomedical platform, Department of Natural 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