{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:30:09Z","timestamp":1784917809277,"version":"3.55.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81261120569"],"award-info":[{"award-number":["81261120569"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370729"],"award-info":[{"award-number":["81370729"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,14]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>NOD-like receptor pyrin 7 (NLRP7) has been identified as the major gene responsible for the recurrent hydatidiform mole (RHM). The immunological role of NLRP7 mutation in HM patients has not been conclusively demonstrated. Hence, we aim to demonstrate this role in our study. We followed 12 new patients with NLRP7 non-synonymous variations (NSVs) from date to date. Peripheral blood mononuclear cells (PBMCs) were collected separately from patients with and without NLRP7 mutation. Supernatant interleukin (IL)-1\u03b2 secretion, intracellular pro-IL-1\u03b2 and mature IL-1\u03b2 expressions were measured after 24\u00a0h lipopolysaccharide (LPS) stimulation. Plasmids with corresponding NSVs were generated to evaluate the ability of processing pro-IL-1\u03b2 into mature IL-1\u03b2 in vitro. Homozygous or compound heterozygous NLRP7 mutations secreted less IL-1\u03b2 in roots of abnormal intracellular pro-IL-1\u03b2 or mature IL-1\u03b2, according to different domains. Plasmids with NSVs could also affect processing or\/and trafficking together with caspase-1 and apoptosis-associated speck-like protein (ASC). Inflammasome-related NLRP7 mutation is a potential mechanism of RHM.<\/jats:p>","DOI":"10.1111\/cei.13472","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T09:28:39Z","timestamp":1591090119000},"page":"72-79","source":"Crossref","is-referenced-by-count":8,"title":["Abnormal processing of IL-1\u03b2 in <i>NLRP7<\/i>-mutated monocytes in hydatidiform mole patients"],"prefix":"10.1093","volume":"202","author":[{"given":"P","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Gynecology, The First Affiliated Hospital, Zhejiang University of Medicine School, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The First Affiliated Hospital, Zhejiang University of Medicine School, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The First Affiliated Hospital, Zhejiang University of Medicine School, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The First Affiliated Hospital, Zhejiang University of Medicine School, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The First Affiliated Hospital, Zhejiang University of Medicine School, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1320-6860","authenticated-orcid":false,"given":"J","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Gynecology, The First Affiliated Hospital, Zhejiang University of Medicine School, Zhejiang University, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"2021121023214244700_cei13472-bib-0001","first-page":"341","article-title":"The demographics of molar pregnancies in England and Wales from 2000\u20132009","volume":"55","author":"Savage","year":"2010","journal-title":"J Reprod 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