{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:41Z","timestamp":1787014001890,"version":"build-2736575974"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":399,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003549","name":"Hungarian National Scientific Research Fund","doi-asserted-by":"publisher","award":["OTKA K-112939"],"award-info":[{"award-number":["OTKA K-112939"]}],"id":[{"id":"10.13039\/501100003549","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CABCOS3","award":["HUHR\/1901\/3.1.1\/0032"],"award-info":[{"award-number":["HUHR\/1901\/3.1.1\/0032"]}]},{"name":"Higher Education Institutional Excellence Programme of the Ministry for Innovation and Technology in Hungary"},{"name":"EFOP","award":["3.6.1-16-2016-00004"],"award-info":[{"award-number":["3.6.1-16-2016-00004"]}]},{"name":"GINOP","award":["232-15-2016-00050"],"award-info":[{"award-number":["232-15-2016-00050"]}]},{"DOI":"10.13039\/501100009615","name":"PTE \u00c1OK-KA","doi-asserted-by":"publisher","award":["2020\/10"],"award-info":[{"award-number":["2020\/10"]}],"id":[{"id":"10.13039\/501100009615","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,12,16]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Infection or vaccine-induced T cell-dependent immune response and the subsequent high-affinity neutralizing antibody production have been extensively studied, while the connection between natural autoantibodies (nAAbs) and disease-specific antibodies has not been thoroughly investigated. Our goal was to find the relationship between immunoglobulin (Ig)M and IgG isotype nAAbs and infection or vaccine-induced and disease-related autoantibody levels in systemic autoimmune diseases (SAD). A previously described indirect enzyme-linked immunosorbent assay (ELISA) test was used for detection of IgM\/IgG nAAbs against citrate synthase (anti-CS) and F4 fragment (anti-F4) of DNA topoisomerase I in 374 SAD samples, with a special focus on systemic lupus erythematosus (SLE) (n\u00a0=\u00a092), rheumatoid arthritis (n\u00a0=\u00a073) and systemic sclerosis (n\u00a0=\u00a0157) disease groups. Anti-measles IgG and anti-dsDNA IgG\/IgM autoantibodies were measured using commercial and in-house indirect ELISA tests. In all SAD groups the anti-measles IgG-seropositive cases showed significantly higher anti-CS IgG titers (P\u00a0=\u00a00\u00b7011). In anti-dsDNA IgG-positive SLE patients, we detected significantly higher levels of anti-CS and anti-F4 IgG nAAbs (P\u00a0=\u00a00\u00b7001 and\u00a0&amp;lt;\u00a00\u00b7001, respectively). Additionally, we found increased levels of IgM isotypes of anti-CS and anti-F4 nAAbs in anti-dsDNA IgM-positive SLE patients (P\u00a0=\u00a00\u00b7002 and 0\u00b7016, respectively). The association between IgG isotypes of pathogen- or autoimmune disease-related antibodies and the IgG nAAbs may underscore the immune response-inducible nature of the diseases investigated. The relationship between protective anti-dsDNA IgM and the IgM isotype of anti-F4 and anti-CS may provide immunoserological evidence for the beneficial roles of nAAbs in SLE patients.<\/jats:p>","DOI":"10.1111\/cei.13521","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T05:01:36Z","timestamp":1600750896000},"page":"32-40","source":"Crossref","is-referenced-by-count":13,"title":["Relationship between natural and infection-induced antibodies in systemic autoimmune diseases (SAD): SLE, SSc and RA"],"prefix":"10.1093","volume":"203","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6126-1840","authenticated-orcid":false,"given":"K","family":"B\u00f6r\u00f6cz","sequence":"first","affiliation":[{"name":"Department of Immunology and Biotechnology, University of P\u00e9cs Medical School, P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotechnology, University of P\u00e9cs Medical School, P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Erd\u0151-Bony\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotechnology, University of P\u00e9cs Medical School, P\u00e9cs, Hungary"},{"name":"Department of Rheumatology and Immunology, University of P\u00e9cs, Medical School, P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K T","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, University of P\u00e9cs, Medical School, P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9","family":"Tuba","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, University of P\u00e9cs, Medical School, P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Czirj\u00e1k","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, University of P\u00e9cs, Medical School, P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"N\u00e9meth","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotechnology, University of P\u00e9cs Medical School, P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Berki","sequence":"additional","affiliation":[{"name":"Department of Immunology and Biotechnology, University of P\u00e9cs Medical School, P\u00e9cs, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"2021121023192441000_cei13521-bib-0001","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.3389\/fimmu.2018.01320","article-title":"Natural autoantibodies: An undersugn hero of the immune system and autoimmune disorders \u2013 a point of view","volume":"9","author":"Avrameas","year":"2018","journal-title":"Front Immunol"},{"key":"2021121023192441000_cei13521-bib-0002","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060726","article-title":"Natural IgG autoantibodies are abundant and ubiquitous in human sera, and their number is influenced by age, gender, and disease","volume":"8","author":"Nagele","year":"2013","journal-title":"PLOS ONE"},{"key":"2021121023192441000_cei13521-bib-0003","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.molimm.2005.11.004","article-title":"A possible new bridge between 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