{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T13:44:04Z","timestamp":1770558244539,"version":"3.49.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":373,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009103","name":"Von-Behring-R\u00f6ntgen-Stiftung","doi-asserted-by":"publisher","award":["64-0019"],"award-info":[{"award-number":["64-0019"]}],"id":[{"id":"10.13039\/100009103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001701","name":"Jos\u00e9 Carreras leukemia foundation","doi-asserted-by":"publisher","award":["GI 20\/8 #39\/2017"],"award-info":[{"award-number":["GI 20\/8 #39\/2017"]}],"id":[{"id":"10.13039\/501100001701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,13]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Extracorporeal photopheresis (ECP) represents one of the most widespread and effective cell therapies for graft-versus-host disease and other T cell-mediated disorders. However, the key factors affecting the therapeutic efficacy of ECP remain unclear. We hypothesized that therapeutic effects are mediated by ECP-treated antigen-presenting dendritic cells (DC). To test this hypothesis, we used the experimental model of contact hypersensitivity (CHS). The ECP's therapeutic activity improved when the total cell dose of the ECP-treated cells was increased. We used different haptens during sensitization to demonstrate that the anti-inflammatory activity of ECP is antigen-specific. This confirmed the hypothesis that professional antigen-presenting cells are involved in the mode of action. Also, the ECP's therapeutic activity was abrogated by the depletion of CD11c+ DC, which represents fewer than 1% of all the ECP-exposed cells. Finally, we confirm the critical importance of CD11c+ DC for ECP activity by showing that only a few purified CD11c+ DC are sufficient to mediate its therapeutic effect. The finding that ECP-treated, physiological antigen-presenting DC alone mediate antigen-specific modulation of a pathological immune response may result in better-targeted interventions when treating patients.<\/jats:p>","DOI":"10.1111\/cei.13539","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T06:18:59Z","timestamp":1603088339000},"page":"329-339","source":"Crossref","is-referenced-by-count":11,"title":["CD11c+ dendritic cells mediate antigen-specific suppression in extracorporeal photopheresis"],"prefix":"10.1093","volume":"203","author":[{"given":"H","family":"Hackstein","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine and Hemostaseology, University Hospital Erlangen, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Kalina","sequence":"additional","affiliation":[{"name":"Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Dorn","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Experimental Dermatology and Allergy Research Group, Justus-Liebig-University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I S","family":"Keil","sequence":"additional","affiliation":[{"name":"Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Baal","sequence":"additional","affiliation":[{"name":"Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Michel","sequence":"additional","affiliation":[{"name":"Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Brendel","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, Immunology, Philipps-University, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Neubauer","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, Immunology, Philipps-University, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Jakob","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, Experimental Dermatology and Allergy Research Group, Justus-Liebig-University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7571-8362","authenticated-orcid":false,"given":"G","family":"Bein","sequence":"additional","affiliation":[{"name":"Institute for Clinical Immunology and Transfusion Medicine, Justus-Liebig-University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,11,8]]},"reference":[{"key":"2021121023211542200_cei13539-bib-0001","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3389\/fmed.2018.00236","article-title":"Extracorporeal photopheresis \u2013 an overview","volume":"5","author":"Cho","year":"2018","journal-title":"Front Med"},{"key":"2021121023211542200_cei13539-bib-0002","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1056\/NEJM198702053160603","article-title":"Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. 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