{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:15:41Z","timestamp":1792793741356,"version":"4.5.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,1,17]],"date-time":"2021-01-17T00:00:00Z","timestamp":1610841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100010408","name":"Polpharma Scientific Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010408","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>We investigated Toll-like receptor (TLR)-3\/-7\/-8\/-9 and interferon (IFN)-\u03b1\/\u03b2\/\u03b3 mRNA expression in whole blood and serum IFN-\u03b1\/\u03b2\/\u03b3 levels in patients with mixed connective tissue disease (MCTD), systemic lupus erythematosus (SLE) and systemic sclerosis (SSc) and in healthy subjects to assess the association between the TLR\u2013IFN expression and severity of and susceptibility to diseases, and identify potential biomarkers. Expression of the IFN-\u03b3, TLR-3 and TLR-8 was detected only in SLE patients. TLR-7, IFN-\u03b1 and IFN-\u03b2 expression was highest in SLE, while TLR-9 expression was highest in SSc patients. In SLE and MCTD patients a strong correlation was observed between TLR-7 and IFN-\u03b1 expression and IFN-\u03b2 and IFN-\u03b1 expression. In MCTD patients, negative correlation between IFN-\u03b1 and TLR-9 and TLR-7 and TLR-9 was revealed. TLR-9 expression in anti-U1-70k-negative, anti-C negative and anti-SmB-negative MCTD patients was higher than in MCTD-positive patients. We observed negative correlations between serum IFN-\u03b1 levels and TLR-7 expression and C3 and C4 levels in SLE patients. In SLE patients we observed that with increased IFN-\u03b3, TLR-3 and TLR-8 expression increased the value of C3 and C4. Our results confirmed that the endosomal TLR\u2013IFN pathway seems to be more important in SLE than in MCTD or SSc, and that IFN-\u03b1 and IFN-\u03b2 may be possible biomarkers for SLE.<\/jats:p>","DOI":"10.1111\/cei.13566","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T15:35:41Z","timestamp":1608305741000},"page":"49-63","source":"Crossref","is-referenced-by-count":36,"title":["Variety of endosomal TLRs and Interferons (IFN-\u03b1, IFN-\u03b2, IFN-\u03b3) expression profiles in patients with SLE, SSc and MCTD"],"prefix":"10.1093","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4249-3136","authenticated-orcid":false,"given":"A","family":"Paradowska-Gorycka","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Wajda","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8179-8066","authenticated-orcid":false,"given":"B","family":"Stypinska","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Walczuk","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Rzeszotarska","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Walczyk","sequence":"additional","affiliation":[{"name":"Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Haladyj","sequence":"additional","affiliation":[{"name":"Eli Lilly and Company, Indianapolis, Indiana, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Romanowska-Prochnicka","sequence":"additional","affiliation":[{"name":"Department of Connective Tissue Diseases, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland"},{"name":"Department of General and Experimental Pathology with Centre for Preclinical Research and Technology (CEPT), Medical University of Warsaw, Warsaw, 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