{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:40:05Z","timestamp":1778643605824,"version":"3.51.4"},"reference-count":112,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,3,7]],"date-time":"2021-03-07T00:00:00Z","timestamp":1615075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["P40RR03640"],"award-info":[{"award-number":["P40RR03640"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20GM103538"],"award-info":[{"award-number":["P20GM103538"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,13]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>Follicular helper T cells (Tfh) cells have been identified in the circulation and in tertiary lymphoid structures in chronic inflammation. Gingival tissues with periodontitis reflect chronic inflammation, so genomic footprints of Tfh cells should occur in these tissues and may differ related to aging effects. Macaca mulatta were used in a ligature-induced periodontitis model [adult group (aged 12\u201323\u00a0years); young group (aged 3\u20137\u00a0years)]. Gingival tissue and subgingival microbiome samples were obtained at matched healthy ligature-induced disease and clinical resolution sites. Microarray analysis examined Tfh genes (n = 54) related to microbiome characteristics documented using 16S MiSeq. An increase in the major transcription factor of Tfh cells, BCL6, was found with disease in both adult and young animals, while master transcription markers of other T cell subsets were either decreased or showed minimal change. Multiple Tfh-related genes, including surface receptors and transcription factors, were also significantly increased during disease. Specific microbiome patterns were significantly associated with profiles indicative of an increased presence\/function of Tfh cells. Importantly, unique microbial complexes showed distinctive patterns of interaction with Tfh genes differing in health and disease and with the age of the animals. An increase in Tfh cell responsiveness occurred in the progression of periodontitis, affected by age and related to specific microbial complexes in the oral microbiome. The capacity of gingival Tfh cells to contribute to localized B cell activation and active antibody responses, including affinity maturation, may be critical for controlling periodontal lesions and contributing to limiting and\/or resolving the lesions.<\/jats:p>","DOI":"10.1111\/cei.13584","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T11:33:47Z","timestamp":1612956827000},"page":"373-395","source":"Crossref","is-referenced-by-count":14,"title":["Gingival transcriptomics of follicular T cell footprints in progressing periodontitis"],"prefix":"10.1093","volume":"204","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9743-6585","authenticated-orcid":false,"given":"J L","family":"Ebersole","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, School of Dental Medicine, University of Nevada Las Vegas, Las Vegas, NV, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S S","family":"Kirakodu","sequence":"additional","affiliation":[{"name":"Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Orraca","sequence":"additional","affiliation":[{"name":"School of Dental Medicine, University of Puerto Rico, San Juan, PR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Gonzalez Martinez","sequence":"additional","affiliation":[{"name":"Caribbean Primate Research Center, University of Puerto Rico, Toa Baja, PR, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O A","family":"Gonzalez","sequence":"additional","affiliation":[{"name":"Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington, KY, USA"},{"name":"Division of Periodontology, College of Dentistry, University of Kentucky, Lexington, KY, 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