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Microvascular alterations are the first event of SSc and injured endothelial cells (ECs) may transdifferentiate towards myofibroblasts, the cells responsible for fibrosis and collagen deposition. This process is identified as endothelial-to-mesenchymal transition (EndMT), and understanding of its development is pivotal to identify early pathogenetic events and new therapeutic targets for SSc. In this review, we have highlighted the molecular mechanisms of EndMT and summarize the evidence of the role played by EndMT during the development of progressive fibrosis in SSc, also exploring the possible therapeutic role of its inhibition.<\/jats:p>","DOI":"10.1111\/cei.13599","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T06:40:42Z","timestamp":1616827242000},"page":"12-27","source":"Crossref","is-referenced-by-count":57,"title":["Endothelial-to-mesenchymal transition in systemic sclerosis"],"prefix":"10.1093","volume":"205","author":[{"given":"P","family":"Di Benedetto","sequence":"first","affiliation":[{"name":"Clinical Pathology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Ruscitti","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Biotechnological and Applied 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