{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T13:00:13Z","timestamp":1768482013246,"version":"3.49.0"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":184,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The objective of this study was to evaluate the predictive role of CD21low B cells as markers of new digital ulcers in systemic sclerosis patients. Peripheral blood B cell subpopulations and clinical assessments have been evaluated in 74 systemic sclerosis patients at baseline and after a 12-month follow-up. After a 12-month follow-up, 23 (31.1%) systemic sclerosis patients developed new digital ulcers. The median percentage of CD21low B cells was significantly higher in patients with than without new digital ulcers [10.1 (4.3\u201313.6) versus 4.8 (3.5\u20137.4); p\u00a0&amp;lt;\u00a00.01]. The 10% cut-off shows good diagnostic accuracy [area under the curve (AUC)\u00a0=\u00a00.732, confidence interval (CI)\u00a0=\u00a00.587\u20130.878; P\u00a0=\u00a00.01]. Kaplan\u2013Meier curves show a significantly reduced free survival from new digital ulcers in systemic sclerosis patients with CD21low B cells\u00a0\u2265\u00a010% (p\u00a0&amp;lt;\u00a00.0001). In multivariate analysis, CD21low B cells\u00a0\u2265\u00a010%, modified Rodnan skin score (mRSS) and systolic pulmonary arterial pressure (sPAP) are associated with the development of new digital ulcers. We hypothesize that CD21low B cells are a predictive marker of new digital ulcers in systemic sclerosis patients.<\/jats:p>","DOI":"10.1111\/cei.13604","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T08:56:55Z","timestamp":1618909015000},"page":"128-134","source":"Crossref","is-referenced-by-count":11,"title":["CD21low B cells are predictive markers of new digital ulcers in systemic sclerosis"],"prefix":"10.1093","volume":"205","author":[{"given":"Marcella","family":"Visentini","sequence":"first","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Pellicano","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Leodori","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona","family":"Marrapodi","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Colantuono","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonietta","family":"Gigante","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, 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