{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:09:41Z","timestamp":1791083381366,"version":"4.1.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":173,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Italian Ministry of Education","award":["PRIN- DESIGN PROJECT"],"award-info":[{"award-number":["PRIN- DESIGN PROJECT"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Ageing dramatically affects number and function of both innate and adaptive arms of immune system, particularly T cell subsets, contributing to reduced vaccination efficacy, decreased resistance to infections and increased prevalence of cancer in older people. In the present paper, we analysed the age-related changes in the absolute number of lymphocytes in 214 Sicilian subjects, and in the percentages of T and natural killer (NK) cells in a subcohort of donors. We compared these results with the immunophenotype of the oldest living Italian supercentenarian (aged 111 years). The results were also sorted by gender. The correlation between number\/percentage of cells and age in all individuals. and separately in males and females, was examined using a simple linear regression analysis. We did not record the increase in the rate of inversion of the CD4\/CD8 ratio, frequently reported as being associated with ageing in literature. Our observation was the direct consequence of a flat average trend of CD4+ and CD8+ T cell percentages in ageing donors, even when gender differences were included. Our results also suggest that CD4+ and CD8+ subsets are not affected equally by age comparing females with males, and we speculated that gender may affect the response to cytomegalovirus (CMV) infection. The supercentenarian showed a unique immunophenotypic signature regarding the relative percentages of her T cell subsets, with CD4+ and CD8+ T cell percentages and CD4+ naive T cell values in line with those recorded for the octogenarian subjects. This suggests that the supercentenarian has a naive \u2018younger\u2019 T cell profile comparable to that of a &amp;gt;80-year-old female.<\/jats:p>","DOI":"10.1111\/cei.13606","type":"journal-article","created":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T18:51:40Z","timestamp":1618771900000},"page":"198-212","source":"Crossref","is-referenced-by-count":43,"title":["Analysis of T and NK cell subsets in the Sicilian population from young to supercentenarian: The role of age and gender"],"prefix":"10.1093","volume":"205","author":[{"given":"Mattia Emanuela","family":"Ligotti","sequence":"first","affiliation":[{"name":"Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy"},{"name":"School of Cancer and Pharmaceutical Sciences, King's College London, The Rayne Institute, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Aiello","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Accardi","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Aprile","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy"},{"name":"Unit of Transfusion Medicine, San Giovanni di Dio Hospital, Agrigento, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriana","family":"Bonura","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Microbiology Section, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bulati","sequence":"additional","affiliation":[{"name":"Research Department, Mediterranean Institute for Transplantation and Advanced Specialized Therapies (IRCCS ISMETT), Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Gervasi","sequence":"additional","affiliation":[{"name":"Specialistic Oncology Laboratory Unit, ARNAS Hospitals Civico, Di Cristina e Benfratelli, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni M","family":"Giammanco","sequence":"additional","affiliation":[{"name":"Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Microbiology Section, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanny","family":"Pojero","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahid","family":"Zareian","sequence":"additional","affiliation":[{"name":"School of Cancer and Pharmaceutical Sciences, King's College London, The Rayne Institute, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8004-2363","authenticated-orcid":false,"given":"Calogero","family":"Caruso","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farzin","family":"Farzaneh","sequence":"additional","affiliation":[{"name":"School of Cancer and Pharmaceutical Sciences, King's College London, The Rayne Institute, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppina","family":"Candore","sequence":"additional","affiliation":[{"name":"Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,17]]},"reference":[{"key":"2021121100031959600_cei13606-bib-0001","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/B978-0-12-374279-7.19003-4","volume-title":"Encyclopedia of immunobiology","author":"Caruso","year":"2016"},{"key":"2021121100031959600_cei13606-bib-0002","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.3389\/fimmu.2019.02247","article-title":"Immunosenescence and its hallmarks: how to oppose aging strategically? A review of potential options for therapeutic intervention","volume":"10","author":"Aiello","year":"2019","journal-title":"Front Immunol"},{"key":"2021121100031959600_cei13606-bib-0003","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.3390\/ijms18081742","article-title":"Markers of T cell senescence in humans","volume":"18","author":"Xu","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2021121100031959600_cei13606-bib-0004","doi-asserted-by":"crossref","first-page":"110887","DOI":"10.1016\/j.exger.2020.110887","article-title":"T cells, aging and senescence","volume":"134","author":"Pangrazzi","year":"2020","journal-title":"Exp Gerontol"},{"key":"2021121100031959600_cei13606-bib-0005","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao2966","article-title":"Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus","volume":"10","author":"Clave","year":"2018","journal-title":"Sci Transl Med"},{"key":"2021121100031959600_cei13606-bib-0006","doi-asserted-by":"crossref","first-page":"685","DOI":"10.3390\/ijms20030685","article-title":"Role of immunogenetics in the outcome of HCMV Infection: implications for ageing","volume":"20","author":"Aiello","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2021121100031959600_cei13606-bib-0007","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.0105-2896.2005.00271.x","article-title":"Human immunosenescence: is it infectious?","volume":"205","author":"Pawelec","year":"2005","journal-title":"Immunol Rev"},{"key":"2021121100031959600_cei13606-bib-0008","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.4049\/jimmunol.1301721","article-title":"Aging and cytomegalovirus infection differentially and jointly affect distinct circulating T cell subsets in humans","volume":"192","author":"Wertheimer","year":"2014","journal-title":"J Immunol"},{"key":"2021121100031959600_cei13606-bib-0009","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10522-015-9563-2","article-title":"Impact of age, sex and CMV-infection on peripheral T cell phenotypes: results from the Berlin BASE-II Study","volume":"16","author":"Di Benedetto","year":"2015","journal-title":"Biogerontology"},{"key":"2021121100031959600_cei13606-bib-0010","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.exger.2007.05.006","article-title":"Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily","volume":"42","author":"Colonna-Romano","year":"2007","journal-title":"Exp Gerontol"},{"key":"2021121100031959600_cei13606-bib-0011","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006624","article-title":"Imbalance in the game of T cells: what can the CD4\/CD8 T-cell ratio tell us about HIV and health?","volume":"13","author":"McBride","year":"2017","journal-title":"PLOS Pathog"},{"key":"2021121100031959600_cei13606-bib-0012","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0047-6374(00)00210-4","article-title":"Age-related change in peripheral blood T-lymphocyte subpopulations and cytomegalovirus infection in the very old: the Swedish longitudinal OCTO immune study","volume":"121","author":"Olsson","year":"2000","journal-title":"Mech Ageing Dev"},{"key":"2021121100031959600_cei13606-bib-0013","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000356827","article-title":"The inverted CD4:CD8 ratio is associated with cytomegalovirus, poor cognitive and functional states in older adults","volume":"21","author":"Luz Correa","year":"2014","journal-title":"NeuroImmunomodulation"},{"key":"2021121100031959600_cei13606-bib-0014","first-page":"396","volume-title":"Handbook of Immunosenescence","author":"Hooten","year":"2018"},{"key":"2021121100031959600_cei13606-bib-0015","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.smim.2012.04.008","article-title":"Innate immunosenescence: effect of aging on cells and receptors of the innate immune system in humans","volume":"24","author":"Solana","year":"2012","journal-title":"Semin Immunol"},{"key":"2021121100031959600_cei13606-bib-0016","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000504493","article-title":"Natural killer cells, aging, and vaccination","volume":"43","author":"Witkowski","year":"2020","journal-title":"Interdiscip Top Gerontol Geriatr"},{"key":"2021121100031959600_cei13606-bib-0017","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-030-20762-5","volume-title":"Centenarians. An example of positive biology","author":"Caruso","year":"2019"},{"key":"2021121100031959600_cei13606-bib-0018","first-page":"841","volume-title":"Handbook of immunosenescence","author":"Bulati","year":"2019"},{"key":"2021121100031959600_cei13606-bib-0019","first-page":"1","volume-title":"Handbook of immunosenescence","author":"Bianchini","year":"2018"},{"key":"2021121100031959600_cei13606-bib-0020","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0167-5699(95)80064-6","article-title":"The immunology of exceptional individuals: the lesson of centenarians","volume":"16","author":"Franceschi","year":"1995","journal-title":"Immunol Today"},{"key":"2021121100031959600_cei13606-bib-0021","author":"Italian National Institute of Statistics"},{"key":"2021121100031959600_cei13606-bib-0022","author":"The Italian supercentenarians database"},{"key":"2021121100031959600_cei13606-bib-0023","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1042\/CS20160004","article-title":"Gender, aging and longevity in humans: an update of an intriguing\/neglected scenario paving the way to a gender-specific medicine","volume":"130","author":"Ostan","year":"2016","journal-title":"Clin Sci"},{"key":"2021121100031959600_cei13606-bib-0024","doi-asserted-by":"crossref","DOI":"10.14336\/AD.2021.0226","article-title":"Age and gender-related variations of molecular and phenotypic parameters in a cohort of Sicilian population: from young to centenarians","volume":"12","author":"Aiello","year":"2021","journal-title":"Aging Dis"},{"key":"2021121100031959600_cei13606-bib-0025","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.3390\/ijms17081316","article-title":"Development of a modular assay for detailed immunophenotyping of peripheral human whole blood samples by multicolor flow cytometry","volume":"17","author":"R\u00fchle","year":"2016","journal-title":"Int J Mol Sci"},{"key":"2021121100031959600_cei13606-bib-0026","doi-asserted-by":"crossref","first-page":"11612","DOI":"10.1038\/s41598-017-11926-2","article-title":"Peripheral human CD4+CD8+ T lymphocytes exhibit a memory phenotype and enhanced responses to IL-2, IL-7 and IL-15","volume":"7","author":"Cl\u00e9net","year":"2017","journal-title":"Sci Rep"},{"key":"2021121100031959600_cei13606-bib-0027","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1365-2567.2008.03027.x","article-title":"CD56bright natural killer (NK) cells: an important NK cell subset","volume":"126","author":"Poli","year":"2009","journal-title":"Immunology"},{"key":"2021121100031959600_cei13606-bib-0028","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1474-9728.2004.00107.x","article-title":"NK and NKT cell functions in immunosenescence","volume":"3","author":"Mocchegiani","year":"2004","journal-title":"Aging Cell"},{"key":"2021121100031959600_cei13606-bib-0029","doi-asserted-by":"crossref","first-page":"24242","DOI":"10.1073\/pnas.1907883116","article-title":"Single-cell transcriptomics reveals expansion of cytotoxic CD4 T cells in supercentenarians","volume":"116","author":"Hashimoto","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021121100031959600_cei13606-bib-0030","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.mad.2004.07.001","article-title":"Age-associated changes in the frequency of na\u00efve, memory and effector CD8+ T cells","volume":"125","author":"Hong","year":"2004","journal-title":"Mech Ageing Dev"},{"key":"2021121100031959600_cei13606-bib-0031","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11357-015-9829-2","article-title":"Effects of aging on human leukocytes (part II): immunophenotyping of adaptive immune B and T cell subsets","volume":"37","author":"Stervbo","year":"2015","journal-title":"Age"},{"key":"2021121100031959600_cei13606-bib-0032","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10522-008-9138-6","article-title":"The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20\u2013100 years of age","volume":"9","author":"Wikby","year":"2008","journal-title":"Biogerontology"},{"key":"2021121100031959600_cei13606-bib-0033","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s11357-012-9400-3","article-title":"The inverted CD4\/CD8 ratio and associated parameters in 66-year-old individuals: the Swedish HEXA immune study","volume":"35","author":"Strindhall","year":"2013","journal-title":"Age"},{"key":"2021121100031959600_cei13606-bib-0034","doi-asserted-by":"crossref","DOI":"10.1111\/febs.15770","article-title":"Hallmarks of the aging T cell system","author":"Zhang","year":"2021","journal-title":"FEBS J"},{"key":"2021121100031959600_cei13606-bib-0035","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.3389\/fmicb.2016.02111","article-title":"Mechanisms underlying T cell immunosenescence: aging and cytomegalovirus infection","volume":"7","author":"Tu","year":"2016","journal-title":"Front Microbiol"},{"key":"2021121100031959600_cei13606-bib-0036","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.mad.2006.04.003","article-title":"The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning","volume":"127","author":"Wikby","year":"2006","journal-title":"Mech Ageing Dev"},{"key":"2021121100031959600_cei13606-bib-0037","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10522-017-9739-z","article-title":"Immune parameters associated with mortality in the elderly are context-dependent: lessons from Sweden, Holland and Belgium","volume":"19","author":"Pawelec","year":"2018","journal-title":"Biogerontology"},{"issue":"Pt 12","key":"2021121100031959600_cei13606-bib-0038","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1099\/vir.0.036004-0","article-title":"Infection with cytomegalovirus but not herpes simplex virus induces the accumulation of late-differentiated CD4+ and CD8+ T-cells in humans","volume":"92","author":"Derhovanessian","year":"2011","journal-title":"J Gen Virol"},{"key":"2021121100031959600_cei13606-bib-0039","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.exger.2017.03.020","article-title":"CD4\/CD8 ratio &lt;1 is associated with lymphocyte subsets, CMV and gender in 71-year old individuals: 5-year follow-up of the Swedish HEXA Immune Longitudinal Study","volume":"95","author":"Strindhall","year":"2017","journal-title":"Exp Gerontol"},{"key":"2021121100031959600_cei13606-bib-0040","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.mad.2005.11.001","article-title":"Accumulation of memory T cells from childhood to old age: central and effector memory cells in CD4(+) versus effector memory and terminally differentiated memory cells in CD8(+) compartment","volume":"127","author":"Saule","year":"2006","journal-title":"Mech Ageing Dev"},{"key":"2021121100031959600_cei13606-bib-0041","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.coi.2005.07.003","article-title":"The effect of aging on cognate function and development of immune memory","volume":"17","author":"Haynes","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"2021121100031959600_cei13606-bib-0042","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.62420","article-title":"The effects of age and systemic metabolism on anti-tumor T cell responses","volume":"9","author":"Drijvers","year":"2020","journal-title":"Elife"},{"key":"2021121100031959600_cei13606-bib-0043","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11357-017-9983-9","article-title":"How does cytomegalovirus factor into diseases of aging and vaccine responses, and by what mechanisms?","volume":"39","author":"Aiello","year":"2017","journal-title":"Geroscience"},{"key":"2021121100031959600_cei13606-bib-0044","doi-asserted-by":"crossref","first-page":"4618","DOI":"10.4049\/jimmunol.1001629","article-title":"Hallmark features of immunosenescence are absent in familial longevity","volume":"185","author":"Derhovanessian","year":"2010","journal-title":"J Immunol"},{"key":"2021121100031959600_cei13606-bib-0045","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1189\/jlb.72.1.65","article-title":"Numerical and functional alterations of circulating gammadelta T lymphocytes in aged people and centenarians","volume":"72","author":"Argentati","year":"2002","journal-title":"J Leukoc Biol"},{"key":"2021121100031959600_cei13606-bib-0046","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.coi.2014.04.002","article-title":"Shaping of NK cell subsets by aging","volume":"29","author":"Solana","year":"2014","journal-title":"Curr Opin Immunol"},{"key":"2021121100031959600_cei13606-bib-0047","first-page":"3128758","article-title":"Immunosenescence of natural killer cells, inflammation, and Alzheimer's disease","volume":"2018","author":"Solana","year":"2018","journal-title":"Int J Alzheimers Dis"},{"key":"2021121100031959600_cei13606-bib-0048","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1742-4933-10-20","article-title":"Sex, gender and immunosenescence: a key to understand the different lifespan between men and women?","volume":"10","author":"Caruso","year":"2013","journal-title":"Immun Ageing"},{"key":"2021121100031959600_cei13606-bib-0049","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/s41467-020-14396-9","article-title":"Sexual-dimorphism in human immune system aging","volume":"11","author":"M\u00e1rquez","year":"2020","journal-title":"Nat Commun"},{"key":"2021121100031959600_cei13606-bib-0050","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1742-4933-9-5","article-title":"\u2018Positive biology\u2019: the centenarian lesson","volume":"9","author":"Caruso","year":"2012","journal-title":"Immun Ageing"},{"key":"2021121100031959600_cei13606-bib-0051","doi-asserted-by":"crossref","first-page":"101299","DOI":"10.1016\/j.arr.2021.101299","article-title":"SARS CoV2 infection _The longevity study perspectives","volume":"67","author":"Lio","year":"2021","journal-title":"Ageing Res Rev"},{"key":"2021121100031959600_cei13606-bib-0052","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1089\/rej.2019.2299","article-title":"The phenotypic characterization of the Cammalleri sisters, an example of exceptional longevity","volume":"23","author":"Accardi","year":"2020","journal-title":"Rejuvenation Res"},{"key":"2021121100031959600_cei13606-bib-0053","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/gerona\/glr223","article-title":"Health span approximates life span among many supercentenarians: compression of morbidity at the approximate limit of life span","volume":"67","author":"Andersen","year":"2012","journal-title":"J Gerontol A Biol Sci Med Sci"}],"container-title":["Clinical and Experimental Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cei.13606","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cei.13606","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/205\/2\/198\/41591516\/cei13606.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/cei\/article-pdf\/205\/2\/198\/41591516\/cei13606.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T16:24:36Z","timestamp":1671899076000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/cei\/article\/205\/2\/198\/6431176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,17]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,6,17]]},"published-print":{"date-parts":[[2021,7,12]]}},"URL":"https:\/\/doi.org\/10.1111\/cei.13606","relation":{},"ISSN":["0009-9104","1365-2249"],"issn-type":[{"value":"0009-9104","type":"print"},{"value":"1365-2249","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,8]]},"published":{"date-parts":[[2021,6,17]]}}}