{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:45:34Z","timestamp":1768815934814,"version":"3.49.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2015-03005"],"award-info":[{"award-number":["2015-03005"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471216"],"award-info":[{"award-number":["81471216"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671186"],"award-info":[{"award-number":["81671186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671177"],"award-info":[{"award-number":["81671177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Guillain\u2013Barr\u00e9 syndrome (GBS) is an acute inflammatory and immune-mediated demyelinating disease of the peripheral nervous system (PNS). Macrophages play a central role in its animal model, experimental autoimmune neuritis (EAN), which has been well accepted. Additionally, nuclear factor (NF)-\u03baB inhibitors have been used to treat cancers and have shown beneficial effects. Here, we investigated the therapeutic effect of M2 macrophage and the NF-\u03baB pathway's correlation with macrophage activation in EAN in C57BL\/6 mice. We demonstrate that M2 macrophage transfusion could alleviate the clinical symptoms of EAN by reducing the proportion of M1 macrophage in the peak period, inhibiting the phosphorylation of NF-\u03baB p65. The NF-\u03baB inhibitor (BAY-11-7082) could alleviate the clinical symptoms of EAN and shorten the duration of symptoms by reducing the proportion of M1 macrophages and the expression of proinflammatory cytokines. Consequently, BAY-11-7082 exhibits strong potential as a therapeutic strategy for ameliorating EAN by influencing the balance of M1\/M2 macrophages and inflammatory cytokines.<\/jats:p>","DOI":"10.1111\/cei.13637","type":"journal-article","created":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T12:40:33Z","timestamp":1623501633000},"page":"110-117","source":"Crossref","is-referenced-by-count":13,"title":["Nuclear factor kappa B inhibitor suppresses experimental autoimmune neuritis in mice via declining macrophages polarization to M1 type"],"prefix":"10.1093","volume":"206","author":[{"given":"Donghui","family":"Shen","sequence":"first","affiliation":[{"name":"Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China"},{"name":"Neuroscience Center, Department of Neurology, Qingdao Municipal Hospital, Qingdao, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-1768","authenticated-orcid":false,"given":"Fengna","family":"Chu","sequence":"additional","affiliation":[{"name":"Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China"},{"name":"Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institute, Karolinska University Hospital Solna, Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Lang","sequence":"additional","affiliation":[{"name":"Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunrong","family":"Li","sequence":"additional","affiliation":[{"name":"Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangding","family":"Liu","sequence":"additional","affiliation":[{"name":"Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Neuroscience Center, Department of Neurology, The First Hospital of Jilin University, Changchun, China"},{"name":"Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics, Karolinska Institute, Karolinska University Hospital Solna, Stockholm, 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