{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T11:02:31Z","timestamp":1772794951745,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T00:00:00Z","timestamp":1359072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate a second\u2010generation assay for basal serum calcitonin (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) measurements compared with the pentagastrin\u2010stimulation test for the diagnosis of inherited medullary thyroid carcinoma (<jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content>) and the follow\u2010up of patients with<jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content>after surgery. Recent American Thyroid Association recommendations suggest the use of basal<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>alone to diagnose and assess follow\u2010up of<jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content>as the pentagastrin (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>g) test is unavailable in many countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Multicentric prospective study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>A total of 162 patients with basal<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>&lt;10\u00a0ng\/l were included: 54 asymptomatic patients harboured noncysteine \u2018rearranged during transfection\u2019 (<jats:italic><jats:styled-content style=\"fixed-case\">RET<\/jats:styled-content><\/jats:italic>) proto\u2010oncogene mutations and 108 patients had entered follow\u2010up of<jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content>after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurement<\/jats:title><jats:p>All patients underwent basal and<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>g\u2010stimulated<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>measurements using a second\u2010generation assay with 5\u2010ng\/l functional sensitivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010five per cent of patients with basal<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u22655\u00a0ng\/l and 25% of patients with basal<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>&lt;5\u00a0ng\/l had a positive<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>g\u2010stimulation test (<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>g<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>&gt;10\u00a0ng\/l). Compared with the reference<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>g test, basal<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u22655\u00a0ng\/l had 99% specificity, a 95%\u2010positive predictive value but only 35% sensitivity (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b70001). Overall, there were 31% less false\u2010negative results using a 5\u2010ng\/l threshold for basal<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>instead of the previously used 10\u2010ng\/l threshold.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The ultrasensitive<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>assay reduces the false\u2010negative rate of basal<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>measurements when diagnosing familial<jats:styled-content style=\"fixed-case\">MTC<\/jats:styled-content>and in postoperative follow\u2010up compared with previously used assays. However, its sensitivity to detect<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\u2010cell disease remains lower than that of the<jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>g\u2010stimulation test.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12001","type":"journal-article","created":{"date-parts":[[2012,8,23]],"date-time":"2012-08-23T08:25:20Z","timestamp":1345710320000},"page":"358-364","source":"Crossref","is-referenced-by-count":18,"title":["Is basal ultrasensitive measurement of calcitonin capable of substituting for the pentagastrin\u2010stimulation test?"],"prefix":"10.1111","volume":"78","author":[{"given":"G\u00e9raldine","family":"Pina","sequence":"first","affiliation":[{"name":"Hospices Civils de Lyon et Universit\u00e9 Lyon 1 Centre de M\u00e9decine Nucl\u00e9aire Centre d'Investigation Clinique et F\u00e9d\u00e9ration d'Endocrinologie Groupement Hospitalier Est Centre de Recherche en Neurosciences Lyon 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