{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T22:44:58Z","timestamp":1783032298426,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T00:00:00Z","timestamp":1363046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Although muscle mass has been shown to be positively related with bone mineral density (<jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>), there are only a few studies that investigated the association between muscle strength or muscle quality and <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content>. We investigated the effects of muscle strength and muscle fat infiltration, as a measure of muscle quality, adjusted for muscle mass on femoral neck <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>orean elderly cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 242 men and 231 women aged over 65\u00a0years who participated in the <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>orean <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ongitudinal <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tudy on <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>geing. Leg muscle mass and femoral neck <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> were measured by dual\u2010energy X\u2010ray absorptiometry. Isokinetic strength of knee extensors was measured as a peak torque value by an isokinetic device. Computed tomography scan of the mid\u2010thigh measured the mean <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ounsfield unit (<jats:styled-content style=\"fixed-case\">HU<\/jats:styled-content>) of the lean tissue. Low bone density was defined as femoral neck <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\u2010score \u2264\u22122\u00b70.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Leg muscle mass, knee extensor strength and thigh muscle <jats:styled-content style=\"fixed-case\">HU<\/jats:styled-content> values were significantly positively correlated with femoral neck <jats:styled-content style=\"fixed-case\">BMD<\/jats:styled-content> in both men and women. However, muscle strength was not a significant determinant for the presence of low bone mass after adjusting for muscle mass in multiple logistic regression analyses. Notably, thigh muscle <jats:styled-content style=\"fixed-case\">HU<\/jats:styled-content> values were strong and independent determinant for the risk of low bone density.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Decreased thigh muscle <jats:styled-content style=\"fixed-case\">HU<\/jats:styled-content> values, a measure of fatty infiltration of muscle, were independently associated with increased risk of low bone density in the elderly population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12016","type":"journal-article","created":{"date-parts":[[2012,8,18]],"date-time":"2012-08-18T12:25:17Z","timestamp":1345292717000},"page":"512-517","source":"Crossref","is-referenced-by-count":20,"title":["Thigh muscle attenuation measured by computed tomography was associated with the risk of low bone density in community\u2010dwelling elderly population"],"prefix":"10.1111","volume":"78","author":[{"given":"Jung Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Hee","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Young","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Woong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry Seoul National University Bundang Hospital Seongnam Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong Soo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan Soo","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hak Chul","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"},{"name":"Department of Internal Medicine 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