{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:42:08Z","timestamp":1768351328514,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Hyperinsulinaemia is an important determinant of the polycystic ovarian syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>). In addition to lifestyle measures, therapeutic strategies include the use of oestrogen\u2013progesterone combination pills (<jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content>), and insulin sensitizers such as metformin, either alone or in combination. Data are limited regarding the impact of metformin alone <jats:italic>vs<\/jats:italic> metformin with <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content> on cardiometabolic risk in overweight adolescents with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>. We hypothesized that metformin alone would lead to an improvement in HbA1C and lipid levels in overweight adolescent girls with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> compared with meformin with <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>Retrospective clinic\u2010based therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and measurements<\/jats:title><jats:p>We examined the effects of therapy with metformin alone (<jats:italic>n<\/jats:italic>\u00a0=\u00a014) <jats:italic>vs<\/jats:italic> metformin with <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a013) on HbA1C and lipid parameters over 10\u201314\u00a0months in 27 overweight girls, drawn from a clinic population of adolescents with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The groups did not differ for age, body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>), HbA1C or baseline lipids. After at least 10\u00a0months, the metformin only group compared with the metformin and <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content> group had a decrease in total cholesterol (\u22120\u00b7605\u00a0\u00b1\u00a00\u00b7100 <jats:italic>vs<\/jats:italic> 0\u00b7170\u00a0\u00b1\u00a00\u00b7348\u00a0m<jats:sc>m<\/jats:sc>,<jats:italic> P<\/jats:italic>\u00a0=\u00a00\u00b702, nonparametric test) and triglycerides (\u22120\u00b7342\u00a0\u00b1\u00a00\u00b7184 <jats:italic>vs<\/jats:italic> 0\u00b7262\u00a0\u00b1\u00a00\u00b7133\u00a0m<jats:sc>m<\/jats:sc>,<jats:italic> P<\/jats:italic>\u00a0=\u00a00\u00b702), despite similar changes in <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (\u22121\u00b76\u00a0\u00b1\u00a00\u00b77 <jats:italic>vs<\/jats:italic> 0\u00b76\u00a0\u00b1\u00a02\u00b71\u00a0kg\/m<jats:sup>2<\/jats:sup>, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b725) and HbA1C (0\u00b703\u00a0\u00b1\u00a00\u00b706 <jats:italic>vs<\/jats:italic> 0\u00b703\u00a0\u00b1\u00a00\u00b713%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b799). Differences between groups remained significant after controlling for baseline parameters and for changes in <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Metformin alone more effectively improves lipid parameters than metformin with <jats:styled-content style=\"fixed-case\">EP<\/jats:styled-content> in adolescent <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>, as indicated by a decrease in total cholesterol and triglycerides. This effect is not related to <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> changes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12028","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T15:21:14Z","timestamp":1346167274000},"page":"199-203","source":"Crossref","is-referenced-by-count":14,"title":["Impact of metformin monotherapy versus metformin with oestrogen\u2010progesterone on lipids in adolescent girls with polycystic ovarian syndrome"],"prefix":"10.1111","volume":"79","author":[{"given":"Miriam A.","family":"Bredella","sequence":"first","affiliation":[{"name":"Department of Radiology Massachusetts General Hospital and Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilpa","family":"McManus","sequence":"additional","affiliation":[{"name":"Pediatric Endocrine Unit Massachusetts General Hospital and Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhusmita","family":"Misra","sequence":"additional","affiliation":[{"name":"Pediatric Endocrine Unit Massachusetts General Hospital and Harvard Medical School Boston MA USA"},{"name":"Neuroendocrine Unit Massachusetts General Hospital and Harvard Medical School Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1687-9856-2011-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.4.8398"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0461"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpag.2009.04.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-38-5-727"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)02993-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.07.1306"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1958"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(03)00073-8"},{"key":"e_1_2_6_11_1","first-page":"107","article-title":"Hormone replacement therapy. 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