{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T09:55:10Z","timestamp":1720864510871},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The widespread application of abdominal computerized tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) imaging has revealed that 0\u00b798\u20134\u00b70% of individuals harbour adrenal lesions (incidentalomas). There is, however, paucity of information regarding the prevalence of adrenal lesions in patients with gastroenteropancreatic neuroendocrine tumours (<jats:styled-content style=\"fixed-case\">GEP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NETS<\/jats:styled-content>). Purpose of this study was to estimate the prevalence of adrenal lesions in patients with <jats:styled-content style=\"fixed-case\">GEP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NETS<\/jats:styled-content> and identify their radiological features and clinical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>The prevalence of adrenal lesions was estimated retrospectively in 438 patients with <jats:styled-content style=\"fixed-case\">GEP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NETS<\/jats:styled-content> who underwent abdominal imaging. Secretory status and changes in size were documented during subsequent follow\u2010up. <jats:styled-content style=\"fixed-case\">MEN<\/jats:styled-content>\u20101 patients and ectopic <jats:styled-content style=\"fixed-case\">ACTH<\/jats:styled-content>\u2010secreting tumours were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adrenal lesions were detected in 32 (8\u00b74%) of 383 patients included. The majority (22 patients \u2013 69%) were located at the left adrenal gland and the mean size was 23\u00b76\u00a0mm. In two patients, one with a well and another with a poorly differentiated tumour, clinicopathological features suggested adrenal metastases. During a mean follow\u2010up period of 69\u00b75\u00a0months, no subsequent growth of any adrenal lesion was observed. Endocrine evaluation documented subclinical glucocorticoid hypersecretion in 4 cases (14%). The presence of adrenal lesions did not correlate to distant metastases, however, they were observed more frequently in patients with G3 tumours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of adrenal lesions in patients with <jats:styled-content style=\"fixed-case\">GEP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NET<\/jats:styled-content>s was found to be higher than the general population and mostly represent benign adrenal adenomas (except patients with G3 tumours). Nevertheless, individualized assessment of imaging characteristics should be still considered.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12046","type":"journal-article","created":{"date-parts":[[2012,9,13]],"date-time":"2012-09-13T10:27:06Z","timestamp":1347532026000},"page":"950-956","source":"Crossref","is-referenced-by-count":3,"title":["The prevalence and relevance of adrenal masses in patients with sporadic gastroenteropancreatic neuroendocrine tumours (<scp>GEP<\/scp>\u2010<scp>NET<\/scp>)"],"prefix":"10.1111","volume":"78","author":[{"given":"George","family":"Kanakis","sequence":"first","affiliation":[{"name":"Department of Pathophysiology (Endocrine Unit) University of Athens Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Kamp","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Sector of Endocrinology Erasmus Medical Centre Rotterdam the 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