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The<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>patients from groups [I+<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>] (12% of these groups) showed higher<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>, fat mass (<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>) and visceral fat when compared with the non\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>patients. In contrast, the<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>patients from group<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>had mean<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>and total<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>similar to those of non\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>patients but showed a reduction of lean body mass and an increase in the relative proportion of trunk<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>similar to the<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>patients from groups [I\u00a0+\u00a0II]. This was associated with an altered lipid profile, high<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\u2010\u03b1 and<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 levels, and reduced adiponectin levels compared to<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>patients from group [I\u00a0+\u00a0<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>] and non\u2010<jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Childhood<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content>survivors treated by<jats:styled-content style=\"fixed-case\">BMT<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TBI<\/jats:styled-content>frequently develop severe insulin resistance associated with peripheral\u2010to\u2010central fat redistribution, rather than increased total<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content>, and low adiponectin levels which may contribute to their increased<jats:styled-content style=\"fixed-case\">CV<\/jats:styled-content>risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12047","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T07:19:03Z","timestamp":1347434343000},"page":"790-798","source":"Crossref","is-referenced-by-count":13,"title":["Characterization of insulin resistance in young adult survivors of childhood acute lymphoblastic leukaemia and non\u2010Hodgkin lymphoma"],"prefix":"10.1111","volume":"78","author":[{"given":"V\u00e9ronique","family":"Beauloye","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology Cliniques St\u2010Luc Universit\u00e9 Catholique de Louvain Brussels 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