{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T06:10:00Z","timestamp":1764655800293},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Despite <jats:styled-content style=\"fixed-case\">NIH<\/jats:styled-content> clinical recommendations, many clinicians are reluctant to replace vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> in patients with hypercalcaemia with primary hyperparathyroidism (<jats:styled-content style=\"fixed-case\">PHP<\/jats:styled-content>) due to concerns over aggravating hypercalcaemia. Furthermore, the optimum level of vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> replacement in <jats:styled-content style=\"fixed-case\">PHP<\/jats:styled-content> remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a large retrospective study to determine whether a relationship exists between serum 25\u2010hydroxyvitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> levels, calcium and other important biochemical markers in patients with <jats:styled-content style=\"fixed-case\">PHP<\/jats:styled-content>. Serum, plasma and urinary biochemical measurements were collected from 251 patients with hypercalcaemia diagnosed with <jats:styled-content style=\"fixed-case\">PHP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>When examining overall mean circulating levels during clinical follow\u2010up, serum 25\u2010hydroxyvitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> correlated highly significantly with plasma parathyroid hormone (<jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>) (r\u00a0=\u00a0\u22120\u00b723, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b70003) and serum phosphate (r\u00a0=\u00a00\u00b716, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b70119). No significant relationship was observed between serum calcium and 25\u2010hydroxyvitamin D (r\u00a0=\u00a00\u00b7002, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b798). Mean plasma <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> during clinical follow\u2010up was 51% lower in patients with serum 25\u2010hydroxyvitamin D\u00a0&gt;\u00a060\u00a0n<jats:sc>m<\/jats:sc> when compared with patients who had 25\u2010hydroxyvitamin D\u00a0&lt;\u00a020\u00a0n<jats:sc>m<\/jats:sc> (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b701).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">PHP<\/jats:styled-content> who have 25\u2010hydroxyvitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> levels\u00a0&gt;\u00a060\u00a0n<jats:sc>m<\/jats:sc> have significantly reduced <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> hypersecretion when compared with patients with deficient vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> levels, without exhibiting worse hypercalcaemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12062","type":"journal-article","created":{"date-parts":[[2012,10,5]],"date-time":"2012-10-05T04:45:27Z","timestamp":1349412327000},"page":"838-843","source":"Crossref","is-referenced-by-count":8,"title":["Associations of serum 25\u2010hydroxyvitamin <scp>D<\/scp> with circulating <scp>PTH<\/scp>, phosphate and calcium in patients with primary hyperparathyroidism"],"prefix":"10.1111","volume":"78","author":[{"given":"Channa N.","family":"Jayasena","sequence":"first","affiliation":[{"name":"Section of Investigative Medicine Imperial College London Hammersmith Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Modi","sequence":"additional","affiliation":[{"name":"Section of Investigative Medicine Imperial College London Hammersmith Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausto","family":"Palazzo","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Imperial College London Hammersmith Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akila","family":"De Silva","sequence":"additional","affiliation":[{"name":"Section of Investigative Medicine Imperial College London Hammersmith Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandy","family":"Donaldson","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry Imperial College Healthcare NHS Trust Charing Cross Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Meeran","sequence":"additional","affiliation":[{"name":"Section of Investigative Medicine Imperial College London Hammersmith Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waljit S.","family":"Dhillo","sequence":"additional","affiliation":[{"name":"Section of Investigative Medicine Imperial College London Hammersmith Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9422-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00100.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02371.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0730659"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.10.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.10.3541"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)00294-6"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-002-6433-2"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.09.018"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-007-9384-9"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1758"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)91333-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(74)90812-2"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.06.032"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1772"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0901"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-009-9211-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e3181fcd772"},{"key":"e_1_2_7_20_1","first-page":"123","article-title":"Management of hypophosphatemia","volume":"7","author":"Lloyd C.W.","year":"1988","journal-title":"Clin Pharm"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12062","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T09:43:04Z","timestamp":1700646184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["10.1111\/cen.12062"],"URL":"https:\/\/doi.org\/10.1111\/cen.12062","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4]]}}}