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Since the discovery of myxoedematous cretinism and thyroid destruction following selenium repletion in iodine\u2010 and selenium\u2010deficient children, data on links between thyroid metabolism and selenium have multiplied. Although very minor amounts of selenium appear sufficient for adequate activity of deiodinases, thus limiting the impact of its potential deficiency on synthesis of thyroid hormones, selenium status appears to have an impact on the development of thyroid pathologies. The value of selenium supplementation in autoimmune thyroid disorders has been emphasized. Most authors attribute the effect of supplementation on the immune system to the regulation of the production of reactive oxygen species and their metabolites. In patients with Hashimoto's disease and in pregnant women with anti\u2010<jats:styled-content style=\"fixed-case\">TPO<\/jats:styled-content> antibodies, selenium supplementation decreases anti\u2010thyroid antibody levels and improves the ultrasound structure of the thyroid gland. Although clinical applications still need to be defined for Hashimoto's disease, they are very interesting for pregnant women given that supplementation significantly decreases the percentage of postpartum thyroiditis and definitive hypothyroidism. In <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>raves' disease, selenium supplementation results in euthyroidism being achieved more rapidly and appears to have a beneficial effect on mild inflammatory orbitopathy. A risk of diabetes has been reported following long\u2010term selenium supplementation, but few data are available on the side effects associated with such supplementation and further studies are required.<\/jats:p>","DOI":"10.1111\/cen.12066","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T12:16:24Z","timestamp":1349784984000},"page":"155-164","source":"Crossref","is-referenced-by-count":172,"title":["Selenium and the thyroid gland: more good news for clinicians"],"prefix":"10.1111","volume":"78","author":[{"given":"Anne","family":"Drutel","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolic diseases H\u00f4pital du Cluzeau Limoges Cedex France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Archambeaud","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic diseases H\u00f4pital du Cluzeau Limoges Cedex 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