{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T10:03:06Z","timestamp":1769940186827,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,1]],"date-time":"2013-04-01T00:00:00Z","timestamp":1364774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background and objective<\/jats:title><jats:p>Intra\u2010operative parathyroid hormone (<jats:styled-content style=\"fixed-case\">IOPTH<\/jats:styled-content>) kinetics and therefore the efficacy of <jats:styled-content style=\"fixed-case\">IOPTH<\/jats:styled-content> utilization as a predictor of cure are likely to be affected by baseline <jats:styled-content style=\"fixed-case\">IOPTH<\/jats:styled-content> levels, vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> deficiency and parathyroid weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Consecutive subjects with primary hyperparathyroidism (<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>,<jats:italic> n<\/jats:italic>\u00a0=\u00a051) undergoing parathyroidectomy with <jats:styled-content style=\"fixed-case\">IOPTH<\/jats:styled-content> monitoring were studied prospectively during the period October 2009\u2013November 2011. Samples were collected pre\u2010incision, pre\u2010excision and post\u2010excision (5, 10, 15\u00a0min). Iterative analysis of <jats:styled-content style=\"fixed-case\">IOPTH<\/jats:styled-content> kinetics and half\u2010life calculation was carried out in subgroups. Nonparametric testing was used for group statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hypovitaminosis <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> (25(<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>)<jats:styled-content style=\"fixed-case\">D<\/jats:styled-content><jats:sub>3<\/jats:sub>\u00a0&lt;\u00a050\u00a0n<jats:sc>m<\/jats:sc>) was present in 39 (76%), serum <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\u00a0&gt;\u00a01000\u00a0ng\/l in 23 (45%), and giant parathyroid adenoma (weight\u00a0&gt;\u00a03000\u00a0mg) in 23 (45%). The percentage drop at 10\u00a0min was significantly higher in large adenomas (weight\u00a0&gt;\u00a03000\u00a0mg). Miami and 5\u00a0min criteria showed the highest negative predictive value and maximum accuracy. The average percentage <jats:styled-content style=\"fixed-case\">IOPTH<\/jats:styled-content> drop observed at 5\u00a0min post\u2010excision was 79\u00b78%. Kinetic analysis showed a mean half\u2010life of <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> of 2\u00b757\u00a0\u00b1\u00a00\u00b727\u00a0min (range: 0\u00b707\u201311\u00b755).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IOPTH<\/jats:styled-content> monitoring is reliable even in patients with extremely high baseline <jats:styled-content style=\"fixed-case\">IOPTH<\/jats:styled-content> value, with a greater percentage drop at 5 and 10\u00a0min post\u2010excision. In patients with high baseline <jats:styled-content style=\"fixed-case\">IOPTH<\/jats:styled-content>, a 50% decay in <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content> value at 5\u00a0min may be indicative of cure, obviating the need for 10 and 15\u00a0min samples. <jats:styled-content style=\"fixed-case\">IOPTH<\/jats:styled-content> kinetics are altered by adenoma weight but not affected by vitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> status or baseline <jats:styled-content style=\"fixed-case\">IOPTH<\/jats:styled-content> levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12067","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T12:16:52Z","timestamp":1349785012000},"page":"935-941","source":"Crossref","is-referenced-by-count":19,"title":["Intra\u2010operative parathyroid hormone kinetics and influencing factors with high baseline <scp>PTH<\/scp>: a prospective study"],"prefix":"10.1111","volume":"78","author":[{"given":"Dependra N.","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery Sanjay Gandhi Post Graduate Institute of Medical Sciences India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sushil K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyan","family":"Chand","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Sanjay Gandhi Post Graduate Institute of Medical Sciences India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjali","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery Sanjay Gandhi Post Graduate Institute of Medical Sciences 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