{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:29:19Z","timestamp":1769920159736,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,4,6]],"date-time":"2013-04-06T00:00:00Z","timestamp":1365206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The liver\u2010secreted protein fetuin\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> is associated with insulin resistance, metabolic syndrome, type 2 diabetes and atherosclerosis. We examined the effect of caloric restriction (<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) on fetuin\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> levels and concomitant changes in hepatic steatosis and cardiovascular risk factors in rats and humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Subjects<\/jats:title><jats:p>We performed a randomized, controlled clinical trial to examine circulating fetuin\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> levels and cardiovascular risk parameters including visceral fat area (<jats:styled-content style=\"fixed-case\">VFA<\/jats:styled-content>), atherogenic lipid profile, inflammatory markers, adipokines levels and brachial artery endothelial function in 76 overweight women with type 2 diabetes before and after 12\u00a0weeks of <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>. In addition, the effects of <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> on hepatic steatosis and fetuin\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> m<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> expression were evaluated in <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>tuska <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ong <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>vans <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>okushima <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>atty (<jats:styled-content style=\"fixed-case\">OLETF<\/jats:styled-content>) rats, an animal model of obesity and type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Circulating fetuin\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> levels were significantly decreased after 12\u00a0weeks of <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> and were accompanied by improvements in <jats:styled-content style=\"fixed-case\">VFA<\/jats:styled-content>, blood pressure, glucose, lipid profiles and liver function. The <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> group also showed a significant decrease in apolipoprotein <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>, leptin and insulin resistance compared to those in the control group, although endothelial function was not different. Multiple regression analysis showed that the changes in fetuin\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> levels were independently associated with <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> and changes in hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and adiponectin (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u00a00\u00b7156). Moreover, <jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> significantly reduced hepatic steatosis and fetuin\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> expression, as well as weight, glucose, total cholesterol and triglyceride levels, in <jats:styled-content style=\"fixed-case\">OLETF<\/jats:styled-content> rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Caloric restriction significantly reduced the hepatic expression of fetuin\u2010<jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> and its circulating levels and improved several cardiovascular risk factors in obese rats and humans with type 2 diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12076","type":"journal-article","created":{"date-parts":[[2012,10,15]],"date-time":"2012-10-15T17:37:32Z","timestamp":1350322652000},"page":"356-363","source":"Crossref","is-referenced-by-count":54,"title":["The effects of caloric restriction on <scp>F<\/scp>etuin\u2010<scp>A<\/scp> and cardiovascular risk factors in rats and humans: a randomized controlled trial"],"prefix":"10.1111","volume":"79","author":[{"given":"Kyung Mook","family":"Choi","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine Korea University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Ah","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Eulji University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Jung","family":"Ahn","sequence":"additional","affiliation":[{"name":"Diabetes Center Eulji Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine Korea University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Young","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Medicine Korea University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baek\u2010Hui","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine Korea University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho Cheol","family":"Hong","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine Korea University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae Yoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine Korea University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sae Jeong","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine Korea University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Jin","family":"Yoo","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine Korea University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sei Hyun","family":"Baik","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine Korea University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Seop","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal 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