{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:45:19Z","timestamp":1774356319931,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,4,13]],"date-time":"2013-04-13T00:00:00Z","timestamp":1365811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Primary hyperparathyroidism and calcium supplementation have been linked to cardiovascular outcomes. The study objective was to examine plasma calcium as a predictor of cardiovascular disease in the general population, as results from previous cohort studies are conflicting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design, participants and measurements<\/jats:title><jats:p>Plasma calcium was measured in 4003 participants (aged 25\u201384\u00a0years) in the 1994\/1995 <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>usselton <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>urvey. Using a <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ox proportional hazards model, we examined albumin\u2010corrected calcium as a predictor of total mortality, cardiovascular mortality and cardiovascular events up to the end of 2010.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, there were significant positive relationships between plasma calcium and each of body mass index, systolic and diastolic blood pressure, glucose and total cholesterol. During the follow\u2010up period, 666 participants died (278 from cardiovascular disease) and 652 had incident cardiovascular events. After adjustment for age and sex, each additional 0\u00b71\u00a0m<jats:sc>m<\/jats:sc> of albumin\u2010corrected calcium at baseline was associated with a hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) of 1\u00b709 [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 0\u00b799, 1\u00b720; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7062] for total mortality, 1\u00b706 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0\u00b792, 1\u00b723; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b741) for cardiovascular mortality and 1\u00b713 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1\u00b703, 1\u00b724; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7012) for cardiovascular events. These associations were attenuated by further adjustment for standard cardiovascular risk factors with <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1\u00b703 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0\u00b794, 1\u00b714), 0\u00b799 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0\u00b786, 1\u00b716) and 1\u00b705 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0\u00b795, 1\u00b715), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After adjustment for age and sex, plasma calcium is a predictor of cardiovascular events. This appears to be mediated by conventional cardiovascular risk factors, and calcium is not an independent predictor of cardiovascular disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12081","type":"journal-article","created":{"date-parts":[[2013,4,13]],"date-time":"2013-04-13T07:30:39Z","timestamp":1365838239000},"page":"852-857","source":"Crossref","is-referenced-by-count":19,"title":["Plasma calcium as a predictor of cardiovascular disease in a community\u2010based cohort"],"prefix":"10.1111","volume":"78","author":[{"given":"John P.","family":"Walsh","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Diabetes Sir Charles Gairdner Hospital Nedlands WA Australia"},{"name":"School of Medicine and Pharmacology The University of Western Australia Crawley WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark L.","family":"Divitini","sequence":"additional","affiliation":[{"name":"School of Population Health The University of Western Australia Crawley WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew W.","family":"Knuiman","sequence":"additional","affiliation":[{"name":"School of Population Health The University of Western Australia Crawley WA Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2012.03.034"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1760"},{"issue":"2","key":"e_1_2_7_4_1","first-page":"S111","article-title":"Longitudinal studies of mild primary hyperparathyroidism","volume":"6","author":"Ljunghall S.","year":"1991","journal-title":"Journal of Bone and Mineral 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