{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T08:10:56Z","timestamp":1772179856159,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,27]],"date-time":"2013-04-27T00:00:00Z","timestamp":1367020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Serum thyroglobulin (Tg) has been associated with a number of thyroid disorders and has been proposed as an indicator of iodine deficiency in a population. However, few studies have addressed the epidemiology of Tg in a population\u2010based setting or in the context of exposure to radioactive iodine\u2010131 (I\u2010131). Our objective was to evaluate baseline levels of Tg in relation to sociodemographic characteristics, iodine status and thyroid function for individuals exposed to I\u2010131.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A population\u2010based cohort assembled in Belarus following the Chornobyl accident provided demographic factors, clinical data and physiological measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>Our analytical sample included 10\u00a0344 subjects of whom 7890 had no thyroid disease and 2454 had evidence of structural or functional thyroid abnormality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Standardized assays were used to measure serum Tg, urinary iodine, <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> and antibodies to Tg and thyroid peroxidase. Ultrasound was used to assess the presence of nodules and estimate thyroid volume.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the fully adjusted model, percent change in Tg was significantly increased among females, smokers and subjects of older age and Tg increased with decreasing urinary iodine concentration, increasing serum <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content> and increasing thyroid volume (<jats:italic>P<\/jats:italic>\u2010values for trend &lt;0\u00b70001), and presence of thyroid nodules (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). We found a complex interaction between region of residence, rural\/urban living, presence\/absence of thyroid abnormalities and serum Tg (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b70001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In residents of Belarus, serum Tg is significantly related to presence of thyroid abnormalities as well as indicators of thyroid function and iodine deficiency and, therefore, could be used to characterize the iodine status and thyroid function of individuals in the context of epidemiological study.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12107","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T15:22:40Z","timestamp":1354202560000},"page":"120-127","source":"Crossref","is-referenced-by-count":12,"title":["Factors associated with serum thyroglobulin levels in a population living in Belarus"],"prefix":"10.1111","volume":"79","author":[{"given":"Elizabeth K.","family":"Cahoon","sequence":"first","affiliation":[{"name":"Radiation Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute DHHS NIH Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Rozhko","sequence":"additional","affiliation":[{"name":"Research Department Republican Center for Radiation Medicine and Human Ecology Gomel Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maureen","family":"Hatch","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute DHHS NIH Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Polyanskaya","sequence":"additional","affiliation":[{"name":"Research Department Republican Center for Radiation Medicine and Human Ecology Gomel Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evgenia","family":"Ostroumova","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Branch Division of Cancer Epidemiology and Genetics National Cancer Institute DHHS NIH Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Computational Biology, Dana\u2010Farber Cancer Institute, and Department of Biostatistics Harvard School of Public Health Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eldar","family":"Nadirov","sequence":"additional","affiliation":[{"name":"Research Department Republican Center for Radiation Medicine and Human Ecology Gomel Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilina","family":"Yauseyenka","sequence":"additional","affiliation":[{"name":"Research Department Republican Center for Radiation Medicine and Human Ecology Gomel Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Savasteeva","sequence":"additional","affiliation":[{"name":"Research Department Republican Center for Radiation Medicine and Human Ecology Gomel Belarus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"McConnell","sequence":"additional","affiliation":[{"name":"The Thyroid Center Department of Medicine College of Physicians and Surgeons Columbia University New York Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth M.","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Biostatistics Branch Division of Cancer Epidemiology and Genetics National Cancer Institute DHHS NIH Bethesda Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina V.","family":"Brenner","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Branch Division 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