{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T23:43:00Z","timestamp":1773790980437,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,27]],"date-time":"2013-04-27T00:00:00Z","timestamp":1367020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the Italian experience on cinacalcet use following its approval by the European Medical Agency (<jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content>) to control hypercalcaemia in patients with primary hyperparathyroidism (<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective data collection from 100 patients with sporadic (s<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>) and 35 with familial <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> (f<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>) followed in eight Italian centres between October 2008 and March 2011.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Albumin\u2010adjusted serum calcium, <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>, 25<jats:styled-content style=\"fixed-case\">OHD<\/jats:styled-content>, daily cinacalcet dose and adverse events were recorded during the follow\u2010up (1\u201346\u00a0months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline serum calcium was 2\u00b790\u00a0\u00b1\u00a00\u00b727\u00a0nmol\/l in s<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> and 2\u00b775\u00a0\u00b1\u00a00\u00b717\u00a0nmol\/l in f<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> patients (<jats:italic>P\u00a0<\/jats:italic>=\u00a00\u00b7007). The cinacalcet <jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content> labelling was met in 53% s<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> and 26% f<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> patients. High surgical risk (34%), negative preoperative imaging (19%), control of hypercalcaemia before parathyroidectomy (<jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content>x) (24%), and refusal of <jats:styled-content style=\"fixed-case\">PT<\/jats:styled-content>x (19%) accounted for cinacalcet prescription in 96% of s<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> patients. Conversely, initial treatment (34%), persistent\/relapsing <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> after surgery (31%), and refusal of PTx (14%) were the indications in 79% f<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> patients. Cinacalcet was started at 30\u00a0mg\/daily in 64% of s<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> and 91% of f<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> and increased until normocalcaemia was reached or side effects occurred. The final daily dose ranged between 15 and 120\u00a0mg. The majority of patients (65% of s<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> and 80% of f<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>) become normocalcaemic. Treatment was withdrawn in six patients because of side effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There is a wide heterogeneity in the prescription of cinacalcet in <jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> patients in Italy and the <jats:styled-content style=\"fixed-case\">EMA<\/jats:styled-content> labelling is not always followed, particularly in f<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> patients. Cinacalcet effectively reduces serum calcium in patients with either s<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content> or f<jats:styled-content style=\"fixed-case\">PHPT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12108","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T12:16:26Z","timestamp":1355400986000},"page":"20-26","source":"Crossref","is-referenced-by-count":33,"title":["Cinacalcet in the management of primary hyperparathyroidism: post marketing experience of an Italian multicentre group"],"prefix":"10.1111","volume":"79","author":[{"given":"Federica","family":"Saponaro","sequence":"first","affiliation":[{"name":"Dipartimento di Endocrinologia e Metabolismo Universit\u00e0 di Pisa Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antongiulio","family":"Faggiano","sequence":"additional","affiliation":[{"name":"Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica Universit\u00e0 di Napoli Federico II Napoli Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Grimaldi","sequence":"additional","affiliation":[{"name":"SOC di Endocrinologia e Malattie del Metabolismo Azienda Ospedaliero\u2010Universitaria Santa Maria della Misericordia di Udine Udine Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Borretta","sequence":"additional","affiliation":[{"name":"Endocrinologia e Malattie del Ricambio ASO S. Croce e Carlo Cuneo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Brandi","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Interna Universit\u00e0 di Firenze Firenze Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Minisola","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Interna Universit\u00e0 degli Studi di Roma Sapienza Roma Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Frasoldati","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Endocrinologia Arcispedale Santa Maria Nuova Reggio Emilia Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Papini","sequence":"additional","affiliation":[{"name":"Dipartimento di Malattie Endocrine Metaboliche e Digestive Ospedale Regina Apostolorum Albano Laziale Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Scillitani","sequence":"additional","affiliation":[{"name":"Unit\u00e0 Operativa di Endocrinologia Ospedale Casa Sollievo della Sofferenza San Giovanni Rotondo Foggia Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Banti","sequence":"additional","affiliation":[{"name":"Dipartimento di Endocrinologia e Metabolismo Universit\u00e0 di Pisa Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela Del","family":"Prete","sequence":"additional","affiliation":[{"name":"Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica Universit\u00e0 di Napoli Federico II Napoli Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Vescini","sequence":"additional","affiliation":[{"name":"SOC di Endocrinologia e Malattie del Metabolismo Azienda Ospedaliero\u2010Universitaria Santa Maria della Misericordia di Udine Udine Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Gianotti","sequence":"additional","affiliation":[{"name":"Endocrinologia e Malattie del Ricambio ASO S. Croce e Carlo Cuneo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loredana","family":"Cavalli","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Interna Universit\u00e0 di Firenze Firenze Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Romagnoli","sequence":"additional","affiliation":[{"name":"Dipartimento di Medicina Interna Universit\u00e0 degli Studi di Roma Sapienza Roma Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annamaria","family":"Colao","sequence":"additional","affiliation":[{"name":"Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica Universit\u00e0 di Napoli Federico II Napoli Italia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filomena","family":"Cetani","sequence":"additional","affiliation":[{"name":"Dipartimento di Endocrinologia e Metabolismo Universit\u00e0 di Pisa Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Marcocci","sequence":"additional","affiliation":[{"name":"Dipartimento di Endocrinologia e Metabolismo Universit\u00e0 di Pisa Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1106636"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318208fed9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1763"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.057273"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1586\/eem.11.84"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0842"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1472"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2640"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1221"},{"key":"e_1_2_7_11_1","first-page":"655","volume":"35","author":"Cetani F.","year":"2012","journal-title":"Journal of Endocrinological Investigation"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpendmet0888"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/906163"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1530\/EJE-12-0117","volume":"167","author":"Filopanti M.","year":"2012","journal-title":"European Journal of Endocrinology"},{"key":"e_1_2_7_15_1","unstructured":"U.F.a.D.A.D.A.P.S.C.H.T. http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2008\/021688s008lbl.pdf(accessed 6 December 2012)."},{"key":"e_1_2_7_16_1","unstructured":"E.M.A.M. http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Assessment_Report_-_Variation\/human\/000570\/WC500028903.pdf(accessed 6 December 2012)."},{"key":"e_1_2_7_17_1","unstructured":"U.F.a.D.A.S.c.t. http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2011\/021688s017lbl.pdf(accessed 6 December 2012)."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2005.09.006"},{"key":"e_1_2_7_19_1","first-page":"90","article-title":"Update on the use of cinacalcet in the management of primary hyperparathyroidism","volume":"35","author":"Marcocci C.","year":"2012","journal-title":"Journal of Endocrinological Investigation"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346443"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03766.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.6.2149"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.07.032"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1762"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-011-9459-0"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T15:21:45Z","timestamp":1697642505000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,27]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["10.1111\/cen.12108"],"URL":"https:\/\/doi.org\/10.1111\/cen.12108","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,27]]}}}