{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T23:28:18Z","timestamp":1780788498758,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,27]],"date-time":"2013-04-27T00:00:00Z","timestamp":1367020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acute lymphoblastic leukaemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>) patients treated with cranial radiotherapy (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>) have an increased risk of <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> deficiency (<jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content>). Little is known about insufficiencies of prolactin (<jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">TSH<\/jats:styled-content>, but also lactation failure has been reported in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the long\u2010term outcome of <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> and thyroid hormone levels in <jats:styled-content style=\"fixed-case\">GHD ALL<\/jats:styled-content> patients and the prevalence of lactation failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case\u2013control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>We examined 40 <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> and 4 <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> insufficient <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> patients, in median 20\u00a0years (range: 8\u201327) after <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> diagnosis and 44 matched population controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> secretion (area under the curve; <jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) after <jats:styled-content style=\"fixed-case\">GHRH<\/jats:styled-content>\u2010arginine test in all patients and matched controls, and <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TSH AUC<\/jats:styled-content> after a <jats:styled-content style=\"fixed-case\">TRH<\/jats:styled-content>\u2010test in 13 patients and 13 controls. And basal <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> and thyroid hormone levels after 5\u00a0years with <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> therapy and 8\u00a0years without <jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content> therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with controls, <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> patients had significantly lower basal and <jats:styled-content style=\"fixed-case\">AUC PRL<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">GHRH<\/jats:styled-content>\u2010Arginine (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b702), and <jats:styled-content style=\"fixed-case\">AUC PRL<\/jats:styled-content> after <jats:styled-content style=\"fixed-case\">TRH<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001). After 5 and 8\u00a0years, <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> levels decreased further (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b701, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b703), but thyroid hormones remained normal at baseline and at follow\u2010up. <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> insufficiency was significantly associated with increased levels of <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and insulin. Six out of seven pregnant <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> women reported lactation failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Long\u2010term <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> survivors treated with <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> have <jats:styled-content style=\"fixed-case\">GHD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> insufficiency, and a high prevalence of lactation failure, but thyroid hormones remained normal. <jats:styled-content style=\"fixed-case\">PRL<\/jats:styled-content> insufficiency was associated with cardiovascular risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12111","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T12:56:18Z","timestamp":1353416178000},"page":"71-78","source":"Crossref","is-referenced-by-count":10,"title":["Prolactin insufficiency but normal thyroid hormone levels after cranial radiotherapy in long\u2010term survivors of childhood leukaemia"],"prefix":"10.1111","volume":"79","author":[{"given":"Cecilia","family":"Follin","sequence":"first","affiliation":[{"name":"Department of Endocrinology Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Link","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sk\u00e5ne University Hospital Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wiebe","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Sk\u00e5ne University Hospital Lund 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