{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:07:20Z","timestamp":1791148040657,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,5,6]],"date-time":"2013-05-06T00:00:00Z","timestamp":1367798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Anorexia nervosa (<jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>) is an eating disorder, resulting in sustained low weight and marked decrease in fat mass. Interleukin 6 (IL\u20106) may play a role in appetite, energy expenditure and body weight control. IL\u20106 acts through binding with membrane receptor (IL\u20106R) and activates glycoprotein 130 (gp130) signalling. Both IL\u20106R and gp130 are present in the blood in the soluble forms (<jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20106R and sgp130 respectively). <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20106R sensitizes cells towards IL\u20106, whereas sgp130 inhibits gp130 signalling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To estimate circulating IL\u20106\/<jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20106R\/sgp130 system and its relationships with body weight and resting energy expenditure (<jats:styled-content style=\"fixed-case\">REE<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>We examined 19 women with <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> and 27 healthy normal\u2010weight female controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p>Indirect calorimetry and the measurement of serum IL\u20106, <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20106R and sgp130 concentrations were performed in all the subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>REE was decreased in AN women (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). Serum IL\u20106 was higher in AN women in comparison with control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005). Serum <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20106R was lower (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7009) and serum sgp130 was higher (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7004) in AN women in comparison with controls. IL\u20106 and <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20106R were related to REE in the entire study population (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120\u00b754, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001 and <jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b748, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001 respectively) and in AN group (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120\u00b754, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7024 and <jats:italic>r<\/jats:italic>\u00a0=\u00a00\u00b760, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7011 respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 in <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content> seems to be compensated by the changes in <jats:styled-content style=\"fixed-case\">sIL<\/jats:styled-content>\u20106R and sgp130, which are directed towards inhibition of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 action. The balance between these factors might play a role in the regulation of energy expenditure in <jats:styled-content style=\"fixed-case\">AN<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12118","type":"journal-article","created":{"date-parts":[[2012,12,1]],"date-time":"2012-12-01T06:28:12Z","timestamp":1354343292000},"page":"812-816","source":"Crossref","is-referenced-by-count":19,"title":["Circulating interleukin 6 and soluble forms of its receptors in relation to resting energy expenditure in women with anorexia nervosa"],"prefix":"10.1111","volume":"79","author":[{"given":"Monika","family":"Karczewska\u2010Kupczewska","sequence":"first","affiliation":[{"name":"Department of Endocrinology Diabetology and Internal Medicine Medical University of Bialystok Bialystok"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Adamska","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Diabetology and Internal Medicine 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