{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T16:21:05Z","timestamp":1774282865554,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,5,11]],"date-time":"2013-05-11T00:00:00Z","timestamp":1368230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the frequencies of three paraoxonase (<jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>)1 polymorphisms in Greek polycystic ovary syndrome (<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content>) and non\u2010<jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women, and their genotypes association with hyperandrogenaemia and insulin resistance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case\u2013control genetic association study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>University Hospital Endocrine Unit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>A total of 142 <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> cases (NIH criteria) and 112 controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main Outcome Measure<\/jats:title><jats:p>Genotyping of the c.\u2013108C&gt;T (<jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1\u2010108), the c.163T&gt;A (<jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1\u201055) and the c.575A&gt;G (<jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1\u2010192) polymorphisms and measurement of baseline androgen and insulin resistance profile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1\u2010108 TT and <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1\u2010192 RR genotypes were more frequently encountered in the <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> than in the control group. The <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1\u2010192 R allele frequency was greater in the <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> than in the control group. Comparing the <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> and the control groups, statistical significances favoured a recessive and a dominant genetic model, respectively, for the single <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1\u2010108 T and <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1\u2010192 R alleles. Free Androgen Index (<jats:styled-content style=\"fixed-case\">FAI<\/jats:styled-content>) levels were higher in patients with <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1\u2010108 TT, whereas Testosterone, <jats:styled-content style=\"fixed-case\">FAI<\/jats:styled-content> and Dehydroepiandrosterone sulphate (<jats:styled-content style=\"fixed-case\">DHEAS<\/jats:styled-content>) levels were higher in patients with <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1\u2010192 RR than patients with the wild or the heterozygous genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The decreased <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1 activity\u2010associated <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1\u2010108 TT and the <jats:styled-content style=\"fixed-case\">PON<\/jats:styled-content>1\u2010192 RR genotypes are more frequently found in Greek <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> women and are associated with hyperandrogenaemia. Hyperandrogenaemia must depend also on other genetic factors because the same genotypes were not associated with hyperandrogenaemia in the control group. Through identification of the involved polymorphisms, women with <jats:styled-content style=\"fixed-case\">PCOS<\/jats:styled-content> could potentially have a better therapeutic screening.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12139","type":"journal-article","created":{"date-parts":[[2013,5,11]],"date-time":"2013-05-11T09:04:48Z","timestamp":1368263088000},"page":"259-266","source":"Crossref","is-referenced-by-count":18,"title":["PON1\u2010108 TT and PON1\u2010192 RR genotypes are more frequently encountered in Greek PCOS than non\u2010PCOS women, and are associated with hyperandrogenaemia"],"prefix":"10.1111","volume":"79","author":[{"given":"George","family":"Paltoglou","sequence":"first","affiliation":[{"name":"2nd Department of Obstetrics and Gynaecology Aretaieion University Hospital Athens Medical School Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Tavernarakis","sequence":"additional","affiliation":[{"name":"2nd 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