{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:55:36Z","timestamp":1790970936099,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T00:00:00Z","timestamp":1365120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Chemerin is a novel adipokine implicated in inflammation and obesity. We hypothesized that foetal chemerin would be elevated in gestational diabetes mellitus (<jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>) and correlate with foetal and maternal adiposity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Observational, longitudinal study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and measurements<\/jats:title><jats:p>Foetal chemerin was measured separately in arterial and venous cord blood of 30 infants born to mothers with (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) and without <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a015), in their mothers in early third trimester and at delivery and in amniotic fluid (week 32) of women with <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content>. Expression of chemerin and its receptor in human foetal tissues commercially available and in placental cells was measured by quantitative <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>. Associations between foetal and maternal anthropometric and metabolic variables were assessed in multivariate regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In GDM, foetal arterial but not venous cord blood chemerin levels were elevated by about 60% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705). Venous cord blood chemerin was higher in infants of obese women (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b701). In multivariate analyses, neither amniotic fluid nor cord blood chemerin levels correlated with birth weight or ponderal index. Both arterial and venous chemerin levels were related to maternal chemerin at birth, and arterial chemerin was associated with GDM status in addition. Maternal levels were unaltered in GDM, but higher in maternal obesity. Foetal liver produces fourfold more chemerin <jats:styled-content style=\"fixed-case\">mRNA<\/jats:styled-content> than other foetal tissues, whereas its receptor prevails in spleen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on multivariate analyses, foetal growth appears unrelated to foetal chemerin. Maternal obesity and <jats:styled-content style=\"fixed-case\">GDM<\/jats:styled-content> have differential effects on foetal chemerin levels. Site of major production (liver) and action (spleen) differ in human foetal tissues.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12140","type":"journal-article","created":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T14:49:35Z","timestamp":1357224575000},"page":"65-72","source":"Crossref","is-referenced-by-count":29,"title":["Cord blood chemerin: differential effects of gestational diabetes mellitus and maternal obesity"],"prefix":"10.1111","volume":"80","author":[{"given":"Mireille N. M.","family":"van Poppel","sequence":"first","affiliation":[{"name":"Department of Public and Occupational Health EMGO Institute for Health and Care Research VU University Medical Center Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willibald","family":"Zeck","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva\u2010Christina","family":"Schest","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Hirschmugl","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Wadsack","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gernot","family":"Desoye","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Medical University of Graz Graz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,4,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0380"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0175"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1833"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5507\/bp.2008.033"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2937"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03664.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00586.2009"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2374"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1858"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.01.023"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700793200"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0042"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.1.487"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2010.10.023"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080300"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710487105"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2006.01850.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0671"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0060"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2011.05.002"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-09-0031"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1420623"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.142.2.788"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02498.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20050363"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000304935.19183.07"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.2119\/2008-00058.Rabe"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.1041197"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.08.008"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000282114"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(98)70500-9"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90298-4"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-0436.2008.00302.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/db10-1434"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2403"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90730.2008"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.728648"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1528"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-2077"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02057.x"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-0679"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.34.307"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00187.2011"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2011.11.004"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.06.037"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02510"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.686540"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0794"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12140","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:15:48Z","timestamp":1696259748000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,5]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["10.1111\/cen.12140"],"URL":"https:\/\/doi.org\/10.1111\/cen.12140","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,5]]}}}