{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:46:38Z","timestamp":1790063198319,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,4,5]],"date-time":"2013-04-05T00:00:00Z","timestamp":1365120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The assessment of<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>deficiency in adult patients with Prader\u2010Willi syndrome (<jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content>) has been previously assessed through the evaluation of quantitative parameters, such as the peak value of<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>response to exogenous stimuli. A comprehensive description of the pattern of secretory response obtainable by deconvolution analysis is still lacking. The aim of our study was to characterize the time evolution of responses of<jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content>subjects compared with obese controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and subjects<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>responsiveness was measured following the combined administration of<jats:styled-content style=\"fixed-case\">GHRH<\/jats:styled-content>+arginine to 65<jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content>adults (24 males, 41 females) aged 18\u201341\u00b72\u00a0years, and 17 age\u2010, gender\u2010 and body mass index\u2010matched obese controls.<jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content>subjects were analysed considering the stratification on different genotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>response to<jats:styled-content style=\"fixed-case\">GHRH<\/jats:styled-content>+arginine was analysed in terms of peak values, standard area under the curves (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>s),<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>s due to the stimulus,<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>s of the Instantaneous Secretion Rate signal and Secretion Response Analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In terms of both peak values and<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>responses were statistically different between<jats:styled-content style=\"fixed-case\">PWS UPD<\/jats:styled-content>15 and<jats:styled-content style=\"fixed-case\">PWS DEL<\/jats:styled-content>15 subjects as well as between<jats:styled-content style=\"fixed-case\">PWS UPD<\/jats:styled-content>15 and obese controls.<jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content>subjects showed a lower and a more delayed<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>response compared with obese controls. Moreover,<jats:styled-content style=\"fixed-case\">PWS UPD<\/jats:styled-content>15 subjects had the most delayed<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings demonstrate that impaired<jats:styled-content style=\"fixed-case\">GH<\/jats:styled-content>secretion in<jats:styled-content style=\"fixed-case\">PWS<\/jats:styled-content>subjects compared with obese controls regards not only amplitude parameters such as peak value and<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>, but also the shape of the secretory response, which is more delayed, especially for<jats:styled-content style=\"fixed-case\">UPD<\/jats:styled-content>15 subjects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12142","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T17:55:07Z","timestamp":1357840507000},"page":"224-231","source":"Crossref","is-referenced-by-count":15,"title":["Deconvolution\u2010based assessment of pituitary<scp>GH<\/scp>secretion stimulated with<scp>GHRH<\/scp>+arginine in<scp>P<\/scp>rader\u2010<scp>W<\/scp>illi adults and obese controls"],"prefix":"10.1111","volume":"79","author":[{"given":"Graziano","family":"Grugni","sequence":"first","affiliation":[{"name":"Istituto Auxologico Italiano Research Institute Experimental Laboratory for Auxo\u2010endocrinological Research Milan and Piancavallo VB Italy"},{"name":"Istituto Auxologico Italiano Research Institute Division of Auxology Piancavallo VB Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Marostica","sequence":"additional","affiliation":[{"name":"Department of Industrial and Information Engineering University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Crin\u00f2","sequence":"additional","affiliation":[{"name":"Ospedale Pediatrico Bambino Ges\u00f9 Research Institute Unit of Autoimmune Endocrine Diseases Palidoro\u2010Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Marzullo","sequence":"additional","affiliation":[{"name":"Istituto Auxologico Italiano Research Institute Division of General Medicine Piancavallo VB Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"De Nicolao","sequence":"additional","affiliation":[{"name":"Department of Industrial and Information Engineering University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sartorio","sequence":"additional","affiliation":[{"name":"Istituto Auxologico Italiano Research Institute Experimental Laboratory for 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