{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:41Z","timestamp":1787014001832,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T00:00:00Z","timestamp":1369008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      High circulating concentrations of parathyroid hormone (\n                      <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\n                      ) have been associated with increased risks of hypertension, left ventricular hypertrophy, congestive heart failure and cardiovascular mortality. Impaired arterial function is a potential mechanism for these associations. We tested whether serum\n                      <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\n                      concentration is associated with measures of arterial function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross\u2010sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>A total of 6545 persons without clinical cardiovascular disease participating in the community\u2010based Multi\u2010Ethnic Study of Atherosclerosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Measurements<\/jats:title>\n                    <jats:p>Brachial artery flow\u2010mediated dilation (FMD) as well as aortic pulse pressure and arterial pulse parameters derived from Windkessel modelling of the radial pressure waveform.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Higher serum\n                      <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\n                      concentration was associated with lower brachial artery FMD (mean difference \u22120\u00b709% per 10\u00a0pg\/ml\n                      <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\n                      ), higher aortic pulse pressure (0\u00b753\u00a0mmHg per 10\u00a0pg\/ml) and reduced\n                      <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>\n                      indkessel capacitive index\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      1 (large artery elasticity, \u22120\u00b712\u00a0ml\/mmHg\u00a0\u00d7\u00a010 per 10\u00a0pg\/ml), adjusting for potential confounding variables (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2010values \u2264 0\u00b7001). These relationships were independent of serum calcium concentration, serum 25\u2010hydroxyvitamin D concentration and estimated glomerular filtration rate and were consistent across relevant participant subgroups. Associations of\n                      <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\n                      with aortic pulse pressure and capacitive index C1 were attenuated after adjustment for blood pressure. Serum\n                      <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\n                      concentration was not associated with the oscillatory index\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      2 (small artery elasticity).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Higher serum\n                      <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\n                      concentration was associated with impaired endothelial function, increased aortic pulse pressure and decreased capacitive index\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      1 in a large, diverse, community\u2010based population. These relationships may help explain previously observed associations of elevated\n                      <jats:styled-content style=\"fixed-case\">PTH<\/jats:styled-content>\n                      with cardiovascular disease.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cen.12163","type":"journal-article","created":{"date-parts":[[2013,2,13]],"date-time":"2013-02-13T03:28:15Z","timestamp":1360726095000},"page":"429-436","source":"Crossref","is-referenced-by-count":63,"title":["Parathyroid hormone and arterial dysfunction in the\n                    <scp>m<\/scp>\n                    ulti\u2010\n                    <scp>e<\/scp>\n                    thnic\n                    <scp>s<\/scp>\n                    tudy of\n                    <scp>a<\/scp>\n                    therosclerosis"],"prefix":"10.1111","volume":"79","author":[{"given":"Cortney","family":"Bosworth","sequence":"first","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute Department of Medicine University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Sachs","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute Department of Medicine University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Duprez","sequence":"additional","affiliation":[{"name":"Cardiovascular Division University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"Hoofnagle","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine and Medicine University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim H.","family":"Ix","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine University of California San Diego"},{"name":"Nephrology Section Veterans Affairs San Diego Healthcare System San Diego CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"David R.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Community Health School of Public Health University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen A.","family":"Peralta","sequence":"additional","affiliation":[{"name":"Department of Medicine University of California San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Siscovick","sequence":"additional","affiliation":[{"name":"Cardiovascular Health Research Unit Departments of Medicine and Epidemiology University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Kestenbaum","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute Departments of Medicine and Epidemiology University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian H.","family":"de Boer","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Kidney Research Institute Departments of Medicine and Epidemiology University of Washington Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32833bc5b4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.296.6625.814"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03345542"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00651.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1210\/jcem.82.1.3666","article-title":"Cardiac abnormalities in patients with primary hyperparathyroidism: implications for follow\u2010up","volume":"82","author":"Stefenelli T.","year":"1997","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.03.069"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.808733"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-0638"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000239757"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0307"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005344-199800001-00042"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1210\/endo.135.3.8070351","article-title":"Parathyroid hormone (PTH)\/PTH\u2010related protein (PTHrP) receptor and its messenger ribonucleic acid in rat aortic vascular smooth muscle cells and UMR osteoblast\u2010like cells: cell\u2010specific regulation by angiotensin\u2010II and PTHrP","volume":"135","author":"Okano K.","year":"1994","journal-title":"Endocrinology"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-006-9166-8"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(00)00130-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1210\/jcem.85.10.6880","article-title":"Augmentation of central arterial pressure in mild primary hyperparathyroidism","volume":"85","author":"Smith J.C.","year":"2000","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf113"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.864801"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03970609"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2011.08.015"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr120"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp319"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/14.2.160"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.11.018"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114248"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.05.007"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.179135"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<681::AID-SIM71>3.0.CO;2-R"},{"key":"e_1_2_6_29_1","volume-title":"Statistical Analysis with Missing Data","author":"Little R.","year":"1987"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00471.2010"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm269"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.1.675"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03346518"},{"key":"e_1_2_6_34_1","first-page":"66","article-title":"Vascular changes in chronic renal disease patients with secondary hyperparathyroidism","volume":"20","author":"Bortotolotto L.A.","year":"2007","journal-title":"Journal of Nephrology"},{"issue":"12","key":"e_1_2_6_35_1","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0895-7061(97)00275-6","article-title":"Effects of PTH(1\u201334) on blood pressure, renal function, and hormones in essential hypertension: the altered pattern of reactivity may counteract raised blood pressure","volume":"10","author":"Jespersen B.","year":"1997","journal-title":"American Journal of Hypertension"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.5.933"},{"key":"e_1_2_6_37_1","first-page":"360","article-title":"Chronic continuous PTH infusion results in hypertension in normal subjects","volume":"2","author":"Hulter H.N.","year":"1986","journal-title":"Journal of Clinical Hypertension"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2011.43"}],"container-title":["Clinical Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcen.12163","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cen.12163","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T14:51:30Z","timestamp":1696344690000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cen.12163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,20]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/cen.12163"],"URL":"https:\/\/doi.org\/10.1111\/cen.12163","archive":["Portico"],"relation":{},"ISSN":["0300-0664","1365-2265"],"issn-type":[{"value":"0300-0664","type":"print"},{"value":"1365-2265","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,20]]}}}