{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:48:28Z","timestamp":1779886108618,"version":"3.53.1"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,5,20]],"date-time":"2013-05-20T00:00:00Z","timestamp":1369008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Endocrinology"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Although previous studies have shown enlargement of adrenal glands in patients with tuberculosis, only few have studied its natural history. Similarly, there have been variable reports of adrenal function in these patients. Some but not all the studies revealed a high prevalence of adrenal insufficiency. The aim of this study was to prospectively study the adrenal cortical function and morphology before and after treatment of pulmonary tuberculosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design and Patients<\/jats:title><jats:p>In a prospective case\u2013control study, 45 patients with acute pulmonary tuberculosis and 45 healthy age\u2010 and gender\u2010matched controls were studied. Adrenal function was tested using a short <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ynacthen test at the baseline and after 6\u00a0months of antitubercular treatment. Size of both adrenal glands was studied using 64 slice <jats:styled-content style=\"fixed-case\">MDCT<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>omatom <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ensation, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>iemens) before and after 6\u00a0months of antitubercular treatment. The findings were compared with a group of healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of cases was 42\u00b74\u00a0\u00b1\u00a020\u00b74\u00a0years and that of controls was 41\u00b71\u00a0\u00b1\u00a017\u00b77\u00a0years. The various clinical and biochemical parameters were comparable between cases and controls. The mean cortisol both basal and one\u2010hour postintravenous <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ynacthen was significantly lower in cases as compared to controls (mean\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content> basal cortisol of 413\u00b757\u00a0\u00b1 108\u00b742\u00a0nmol\/l in cases <jats:italic>vs<\/jats:italic> 615\u00b726\u00a0\u00b1\u00a0108\u00b715\u00a0nmol\/l in controls and post <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ynacthen cortisol of 685\u00b761\u00a0\u00b1\u00a083\u00b787\u00a0nmol\/l in cases <jats:italic>vs<\/jats:italic> 1497\u00b730\u00a0\u00b1\u00a0734\u00b744\u00a0nmol\/l in controls). Both the adrenal length and thickness of the right and left adrenal gland were greater in patients with active tuberculosis compared with controls and reversed to baseline after completion of antitubercular treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adrenal enlargement demonstrated by <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> is common in active tuberculosis and is reversible. Basal and stimulated cortisol is less in patients with pulmonary tuberculosis as compared with healthy controls and increases after antitubercular treatment, although unlike previous studies, none of the patients had adrenal insufficiency.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cen.12170","type":"journal-article","created":{"date-parts":[[2013,2,18]],"date-time":"2013-02-18T16:12:36Z","timestamp":1361203956000},"page":"321-325","source":"Crossref","is-referenced-by-count":23,"title":["Pattern of adrenal morphology and function in pulmonary tuberculosis: response to treatment with antitubercular therapy"],"prefix":"10.1111","volume":"79","author":[{"given":"Bashir A.","family":"Laway","sequence":"first","affiliation":[{"name":"Department of Endocrinology Sher\u2010I\u2010Kashmir Institute of Medical Sciences Srinagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imran","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine Sher\u2010I\u2010Kashmir Institute of Medical Sciences Srinagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashir A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine Sher\u2010I\u2010Kashmir Institute of Medical Sciences Srinagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naseer A.","family":"Choh","sequence":"additional","affiliation":[{"name":"Department of Immunology Sher\u2010I\u2010Kashmir Institute of Medical Sciences Srinagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manzoor A.","family":"Bhat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Sher\u2010I\u2010Kashmir Institute of Medical Sciences Srinagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaffar A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Radio diagnosis Sher\u2010I\u2010Kashmir Institute of Medical Sciences Srinagar India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,5,20]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"WHO(2008)Global tuberculosis control: surveillance planning financing: WHO report. 2008 WHO\/HTM\/TB\/2008393."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2001.01266.x"},{"key":"e_1_2_6_4_1","first-page":"23","article-title":"Clinical profile and prognosis of Addison's disease in India","volume":"14","author":"Agarwal G.","year":"2001","journal-title":"The National Medical Journal of India"},{"key":"e_1_2_6_5_1","first-page":"212","article-title":"Therapeutic strategies in adrenal insufficiency","volume":"62","author":"Oelkers W.","year":"2001","journal-title":"Annales 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